Cytoprotection by bcl-2 gene transfer against ischemic liver injuries together with repressed lipid peroxidation and increased ascorbic acid in livers and serum

Journal of Cellular Biochemistry

Volumn 93, Issue 5, 2004, Pages 857-870

  Yanada, Shinobu ^a,c   Saitoh, Yasukazu ^a,d   Kaneda, Yasufumi ^b   Miwa, Nobuhioko ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Japan Tissue Engineering Co Ltd   (Japan)

^d Ophtecs Corporation   (Japan)

Author keywords

Ascorbic acid; Bcl 2; HVJ liposome; Ischemia reperfusion; Reactive oxygen species (ROS)

Indexed keywords

ALANINE AMINOTRANSFERASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; INDOLE DERIVATIVE; METHYLPHENYLINDOLE; PROTEIN BCL 2; UNCLASSIFIED DRUG; ANTIOXIDANT; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CRYOPROTECTION; DNA STRAND; GENE EXPRESSION; GENE TRANSFER; LIPID PEROXIDATION; LIVER CELL; LIVER ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; APOPTOSIS; CELL LINE; CHEMISTRY; CYTOLOGY; DNA DAMAGE; GENETIC TRANSFECTION; GENETICS; HUMAN; LIVER; MALE; METABOLISM; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; REPERFUSION INJURY; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CELL LINE; DNA DAMAGE; HEPATOCYTES; HUMANS; IN SITU NICK-END LABELING; LIPID PEROXIDATION; LIVER; MALE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; TRANSFECTION;

EID: 19644388935     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20221     Document Type: Article

References (31)

1. Bilbao G, Contreras JL, Gomez-Navarro J, Eckhoff DE, Mikheeva G, Krasnykh V, Hynes T, Thomas FT, Thomas JM, Curiel DT. 1999. Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation. Transplantation 67:775-783.
2. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. 1995. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92(16):7162-7166.
3. Buttke TM, Sandstrom PA. 1994. Oxidative stress as a mediator of apoptosis. Immunol Today 15(1):7-10.
4. Eguchi M, Fujiwara M, Mizukami Y, Miwa N. 2003. Cytoprotection by pro-vitamin C against ischemic injuries in perfused rat heart together with differential activation of MAP kinase family. J Cell Biochem 89:863-867.
5. Ferdinand S-I, Nagy AH, Robert TM. 2001. Hepatic ischemia-reperfusion injury. Am J Surg 181:160-166.
6. Gross A, McDonnell JM, Korsmeyer SJ. 1999. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13(15):1899-1911.
7. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ. 1993. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251.
8. Jacobson MD. 1996. Reactive oxygen species and programmed cell death. Trends Biochem Sci 21:83-86.
9. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE. 1993. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 262(5137):1274-1277.
10. Kerr JF, Wyllie AH, Currie AR. 1972. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26(4):239-257.
11. Kohli V, Selzner M, Madden JF, Bentley RC, Clavien PA. 1999. Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. Transplantation 67:1099-1105.
12. Kroemer G. 1997. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3:614-620.
13. Lin KT, Xue JY, Sun FF, Wong PY. 1997. Reactive oxygen species participate in peroxynitrite-induced apoptosis in HL-60 cells. Biochem Biophys Res Commun 230(1):115-119.
14. Marubayashi S, Dohi K. 1996. Therapeutic modulation of free radical-mediated reperfusion injury of the liver and its surgical implications. Surg Today 26(8):573-580.
15. Marubayashi S, Dohi K, Yamada K, Kawasaki T. 1991. Role of conversion of xanthine dehydrogenase to oxidase in ischemic rat liver cell injury. Surgery 110(3):537-543.
16. McCord JM. 1985. Oxygen-dervied free radicals in post-ischemic injury. N Engl J Med 312:159-163.
17. Oltvai ZN, Milliman CL, Korsmeyer SJ. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74(4):609-619.
18. Reed JC. 1994. Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6.
19. Saeki Y, Matsumoto N, Nakano Y, Mori M, Awai K, Kaneda Y. 1997. Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): Reciprocal effect of cationic lipid for in vitro and in vivo gene transfer. Hum Gene Ther 8(17):2133-2141.
20. Saitoh Y, Ouchida R, Kayasuga A, Miwa N. 2003. Antiapoptotic defense of bcl-2 gene against hydroperoxide-induced cytotoxicity together with suppressed lipid peroxidation, enhanced ascorbate uptake, and upregulated Bcl-2 protein. J Cell Biochem 89:321-334.
21. Shimizu S, Eguchi Y, Kamiike W, Funahashi Y, Mignon A, Lacronique V, Matsuda H, Tsujimoto Y. 1998. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci USA 95(4):1455-1459.
22. Subhasis C, Allan SS, Lawrence TB, Vasant J, Elizabeth MK, Jeffrey B, Y Joseph W, Timothy JG, H Lee S. 2002. Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure. Circulation 106(Suppl I):I212-I217.
23. Suzuki K, Bari M, Ivan AS, Najma L, Jay J, Ryszard TS, Kaneda Y, Sawa Y, Matsuda H, Magdi HY. 2002. Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation 106(Suppl I):I270-I276.
24. Thompson CB. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267(5203):1456-1462.
25. Tsujimoto Y. 1989. Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells. Proc Natl Acad Sci USA 86:1958-1962.
26. Tsujimoto Y. 1998. Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria? Genes Cells 3: 697-707.
27. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. 1985. Involvement of the bcl-2 gene in human follicular lymphoma. Science 228:1440-1443.
28. Vaux DL, Cory S, Adams JM. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442.
29. Yamabe K, Shimizu S, Kamiike W, Waguri S, Eguchi Y, Hasegawa J, Okuno S, Yoshioka Y, Ito T, Sawa Y, Uchiyama Y, Tsujimoto Y, Matsuda H. 1998. Prevention of hypoxic liver cell necrosis by in vivo human bcl-2 gene transfection. Biochem Biophys Res Commun 243(1):217-223.
30. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. 1997. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 275(5303):1129-1132.
31. Zwacka RM, Zhou W, Zhang Y, Darby CJ, Dudus L, Halldorson J, Oberley L, Engelhardt JF. 1998. Redox gene therapy for ischemia/reperfusion Injury of the liver reduces AP1 and NF-kappa B activation. Nature Med 4(6):698-704.