Effects of prenatal methylazoxymethanol acetate (MAM) treatment in rats on water maze performance

Behavioural Brain Research

Volumn 161, Issue 2, 2005, Pages 291-298

  Leng, Andreas ^a   Jongen Rêlo, Ana L ^a   Pothuizen, Helen H J ^a   Feldon, Joram ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Animal model; Prenatal treatment; Reversal learning; Schizophrenia; Spatial memory

Indexed keywords

METHYLAZOXYMETHANOL ACETATE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; MALE; MAZE TEST; NEWBORN; NONHUMAN; PRENATAL PERIOD; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; VALIDATION PROCESS; WORKING MEMORY;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; FEMALE; GESTATIONAL AGE; INHIBITION (PSYCHOLOGY); MALE; MAZE LEARNING; MEMORY; METHYLAZOXYMETHANOL ACETATE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, WISTAR; REACTION TIME; SEX FACTORS; SPATIAL BEHAVIOR; VISUAL PERCEPTION; WATER;

EID: 19544382199     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2005.02.016     Document Type: Article

References (43)

1. J.P. Aggleton, S.D. Vann, C.J. Oswald, and M. Good Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer Hippocampus 10 2000 466 474
2. F. Amenta, C. Cavallotti, M. De Rossi, G. Bossoni, and C. Carpi Effect of acetyl-l-carnitine treatment on some behavioural, histochemical and histological parameters of methylazoxymethanol microencephalic rats Int J Tissue React 8 1986 513 526
3. T. Archer, A. Fredriksson, E. Sundstrom, J. Luthman, T. Lewander, and U. Soderberg Prenatal methylazoxymethanol treatment potentiates d-amphetamine- and methylphenidate-induced motor activity in male and female rats Pharmacol Toxicol 63 1988 233 239
4. T. Archer, A.J. Hiltunen, T.U. Jarbe, M.R. Kamkar, J. Luthman, and E. Sundstrom Hyperactivity and instrumental learning deficits in methylazoxymethanol-treated rat offspring Neurotoxicol Teratol 10 1988 341 347
5. W. Balduini, M. Cimino, G. Lombardelli, M.P. Abbracchio, G. Peruzzi, and T. Cecchini Microencephalic rats as a model for cognitive disorders Clin Neuropharmacol 9 Suppl 3 1986 S8 S18
6. S. Banfi, L. Dorigotti, M.P. Abbracchio, W. Balduini, E. Coen, and C. Ragusa Methylazoxymethanol microencephaly in rats: neurochemical characterization and behavioral studies with the nootropic oxiracetam Pharmacol Res Commun 16 1984 67 83
7. D.M. Bannerman, J.N. Rawlins, S.B. McHugh, R.M. Deacon, B.K. Yee, and T. Bast Regional dissociations within the hippocampus - memory and anxiety Neurosci Biobehav Rev 28 2004 273 283
8. H.E. Cannon-Spoor, and W.J. Freed Hyperactivity induced by prenatal administration of methylazoxymethanol: association with altered performance on conditioning tasks in rats Pharmacol Biochem Behav 20 1984 189 193
9. N. Chevassus-Au-Louis, P. Congar, A. Represa, Y. Ben-Ari, and J.L. Gaiarsa Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex Proc Natl Acad Sci USA 95 1998 10263 10268
10. J.P. de Bruin, F. Sanchez-Santed, R.P. Heinsbroek, A. Donker, and P. Postmes A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: evidence for behavioural flexibility, but not for impaired spatial navigation Brain Res 652 1994 323 333
11. M. Di Luca, F. Merazzi, P.N. De Graan, M. Cimino, W. Balduini, and W.H. Gispen Selective alteration in B-50/GAP-43 phosphorylation in brain areas of animals characterized by cognitive impairment Brain Res 607 1993 329 332
12. D. Dickinson, V.N. Iannone, C.M. Wilk, and J.M. Gold General and specific cognitive deficits in schizophrenia Biol Psychiatry 55 2004 826 833
13. M. Didriksen, F. Sams-Dodd, and J. Arnt Cognitive deficits in rats treated prenatally with the mitosis inhibitor methylaxymethanol (MAM) at different time points during gestation Schizophr Res 36 1999 164
14. M. Fiore, J. Korf, F. Angelucci, L. Talamini, and L. Aloe Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases Physiol Behav 71 2000 57 67
15. M. Fiore, J. Korf, A. Antonelli, L. Talamini, and L. Aloe Long-lasting effects of prenatal MAM treatment on water maze performance in rats: associations with altered brain development and neurotrophin levels Neurotoxicol Teratol 24 2002 179 191
16. M. Fiore, L. Talamini, F. Angelucci, T. Koch, L. Aloe, and J. Korf Prenatal methylazoxymethanol acetate alters behavior and brain NGF levels in young rats: a possible correlation with the development of schizophrenia-like deficits Neuropharmacology 38 1999 857 869
17. P. Flagstad, B.Y. Glenthoj, and M. Didriksen Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia Neuropsychopharmacology 30 2004 250 260
18. P. Flagstad, A. Mork, B.Y. Glenthoj, J. Van Beek, A.T. Michael-Titus Beek, and M. Didriksen Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens Neuropsychopharmacology 29 2004 2052 2064
19. M. Fyhn, S. Molden, M.P. Witter, E.I. Moser, and M.B. Moser Spatial representation in the entorhinal cortex Science 305 2004 1258 1264
20. R. Gourevitch, C. Rocher, G.L. Pen, M.O. Krebs, and T.M. Jay Working memory deficits in adult rats after prenatal disruption of neurogenesis Behav Pharmacol 15 2004 287 292
21. A.L. Jongen-Rêlo, A. Leng, M. Luber, H.H.J. Pothuizen, L. Weber, and J. Feldon The prenatal methylazoxymethanol acetate treatment: a neurodevelopmental animal model for schizophrenia? Behav Brain Res 149 2004 159 181
22. K. Kabat, G.G. Buterbaugh, and C.U. Eccles Methylazoxymethanol as a developmental model of neurotoxicity Neurobehav Toxicol Teratol 7 1985 519 525
23. L. Lacroix, I. White, and J. Feldon Effect of excitotoxic lesions of rat medial prefrontal cortex on spatial memory Behav Brain Res 133 2002 69 81
24. M.H. Lee, and A. Rabe Premature decline in Morris water maze performance of aging microencephalic rats Neurotoxicol Teratol 14 1992 383 392
25. J. Lehmann, and J. Feldon Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing? Rev Neurosci 11 2000 383 408
26. R. Lewis Should cognitive deficit be a diagnostic criterion for schizophrenia? J Psychiatry Neurosci 29 2004 102 113
27. A.K. Mohammed, G. Jonsson, U. Soderberg, and T. Archer Impaired selective attention in methylazoxymethanol-induced microencephalic rats Pharmacol Biochem Behav 24 1986 975 981
28. A.K. Mohammed, G. Jonsson, E. Sundstrom, B.G. Minor, U. Soderberg, and T. Archer Selective attention and place navigation in rats treated prenatally with methylazoxymethanol Brain Res 395 1986 145 155
29. R. Morris Developments of a water-maze procedure for studying spatial learning in the rat J Neurosci Meth 11 1984 47 60
30. E. Moser, M.B. Moser, and P. Andersen Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions J Neurosci 13 1993 3916 3925
31. Y. Nagata, and H. Matsumoto Studies on methylazoxymethanol: methylation of nucleic acids in the fetal rat brain Proc Soc Exp Biol Med 132 1969 383 385
32. Pothuizen HHJ, W.N. Zhang, A.L. Jongen-Rêlo, J. Feldon, and B.K. Yee Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within-subject, within-task comparison of reference and working spatial memory Eur J Neurosci 19 2004 705 712
33. B. Pouzet, H. Welzl, M.K. Gubler, L. Broersen, C.L. Veenman, and J. Feldon The effects of NMDA-induced retrohippocampal lesions on performance of four spatial memory tasks known to be sensitive to hippocampal damage in the rat Eur J Neurosci 11 1999 123 140
34. E.S. Susser, and S.P. Lin Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1944-1945 Arch Gen Psychiatry 49 1992 983 988
35. T. Suzuki, K. Hirooka, K. Kanda, H. Hirooka, and K. Furusawa Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946), a novel cognition activator, on learning and memory in rodent models Biol Pharm Bull 21 1998 698 703
36. N. Takei, P.B. Mortensen, U. Klaening, R.M. Murray, P.C. Sham, and E. O'Callaghan Relationship between in utero exposure to influenza epidemics and risk of schizophrenia in Denmark Biol Psychiatry 40 1996 817 824
37. L.M. Talamini, B. Ellenbroek, T. Koch, and J. Korf Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex implications for schizophrenia Ann NY Acad Sci 911 2000 486 494
38. L.M. Talamini, T. Koch, P.G. Luiten, J.M. Koolhaas, and J. Korf Interruptions of early cortical development affect limbic association areas and social behaviour in rats: possible relevance for neurodevelopmental disorders Brain Res 847 1999 105 120
39. L.M. Talamini, T. Koch, G.J. Ter Horst, and J. Korf Methylazoxymethanol acetate-induced abnormalities in the entorhinal cortex of the rat: parallels with morphological findings in schizophrenia Brain Res 789 1998 293 306
40. M. Tamaru, Y. Hirata, M. Nagayoshi, and T. Matsutani Brain changes in rats induced by prenatal injection of methylazoxymethanol Teratology 37 1988 149 157
41. H.V. Thomas, C. Dalman, A.S. David, J. Gentz, G. Lewis, and P. Allebeck Obstetric complications and risk of schizophrenia: effect of gender, age at diagnosis and maternal history of psychosis Br J Psychiatry 179 2001 409 414
42. K.E. Ward, L. Friedman, A. Wise, and S.C. Schulz Meta-analysis of brain and cranial size in schizophrenia Schizophr Res 22 1996 197 213
43. W.N. Zhang, H.H.J. Pothuizen, J. Feldon, and J.N. Rawlins Dissociation of function within the hippocampus: effects of dorsal, ventral and complete excitotoxic hippocampal lesions on spatial navigation Neuroscience 127 2004 289 300