Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat

Journal of Cardiovascular Pharmacology

Volumn 39, Issue 1, 2002, Pages 73-87

  Sia, Y T ^a   Parker, T G ^a   Tsoporis, J N ^a   Liu, P ^a   Adam, A ^a   Rouleau, J L ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Blocker; Carvedilol; Cytokines; Postinfarction; Remodeling

Indexed keywords

CARVEDILOL; INTERLEUKIN 1BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HEART DILATATION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; HYPOTENSION; MALE; MORTALITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCAR FORMATION; SURVIVAL RATE; TREATMENT OUTCOME;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARBAZOLES; CYTOKINES; FIBROSIS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIUM; NUCLEASE PROTECTION ASSAYS; OXIDATIVE STRESS; PAPILLARY MUSCLES; PROPANOLAMINES; RATS; RATS, WISTAR; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 0036139395     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200201000-00009     Document Type: Article

References (48)

1. Myocardial infarction patients in the 1990s: Their risks factors, stratification and survival in Canada: The Canadian Assessment of Myocardial Infarction (CAMI) Study
2. Frequency, significance and cost of recurrent ischemia after thrombolytic therapy for acute myocardial infarction
3. Post-myocardial infarction ventricular remodeling animal and human studies
4. Arrhythmias and death after coronary artery occlusion in rat: Continuous telemetric ECG monitoring in conscious untreated rats
5. Ventricular remodeling after myocardial infarction: Experimental observations and clinical implications
6. Angiotensin-converting-enzyme inhibition and ventricular remodeling after myocardial infarction
7. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: Results of the Survival and Ventricular Enlargement Trial
8. Myocardial infarction. Effects of β-blockade
9. Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: The CAPRICORN randomised trial
10. β-Adrenergic blockade in developing heart failure: Effects on myocardial inflammatory cytokines, nitric oxide, and remodeling
11. 1-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction
12. Markedly different effects on ventricular remodeling result in decrease in inducibility of ventricular arrythmias
13. Long-term effects of beta-adrenergic blocking agent treatment on hemodynamic function and left ventricular remodeling in rats with experimental myocardial infarction: Importance of timing of treatment and infarct size
14. Protective effects of carvedilol in the myocardium
15. Randomized placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischemic heart disease
16. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
17. Effect of afterload reducing drugs on the pathogenesis of antioxidant changes and congestive heart failure in rat
18. Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
19. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rat
20. Oxygen-mediated myocardial damage during ischemia and reperfusion: Role of the cellular defenses against oxygen toxicity
21. The effect of β-blockers on free radical-induced cardiac contractile dysfunction
22. Hypoxic stress induces cardiac myocyte-derived interleukin-6
23. Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial β-adrenergic receptor sensitivity in the ferret
24. Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice
25. Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes: Involvement of sphingolipid signaling cascade in cardiac death
26. Oxidative stress during myocardial ischemia and heart failure
27. Effect of carvedilol in comparison with metoprolol on myocardial collagen postinfarction
28. Endothelin A receptor blockade causes adverse left ventricular remodeling but improves pulmonary artery pressure after infarction in the rat
29. Carvedilol (Kredex®): A novel multiple action cardiovascular agent
30. Effect of dysfunctional vascular endothelium on myocardial performance in isolated papillary muscles
31. Postinfarction survival and inducibility of ventricular arrhythmias in spontaneously hypertensive rats: Effects of ramipril and hydralazine
32. 1-adrenergic induction of hypertrophic phenotype in cardiac myocyte
33. Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors
34. Interleukin-1β induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture
35. Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium
36. Determination of aldehydes and other lipid peroxidation products in biologic samples by gas chromatography mass spectrometry
37. Endocardial endothelium and myocardial performance in rats: Effects of changing extracellular calcium and phenylephrine
38. Cytokines expression increases in nonmyocytes from rats with postinfarction heart failure
39. Catecholamines and cardiac hypertrophy
40. Wall stress and pattern of hypertrophy in the human left ventricle
41. Response of hypertensive left ventricular hypertrophy and coronary microvascular disease to calcium antagonists
42. Early apoptosis in human myocardial infarction
43. Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure
44. Novel mechanism in the treatment of heart failure: Inhibition of oxygen-radical and apoptosis by carvedilol
45. Favorable left ventricular remodeling following large myocardial infarction by exercise training: Effect on ventricular morphology and gene expression
46. Optimization of myocardial function
47. Effects of the early administration of enalapril on mortality in patients with myocardial infarction: Results of the Cooperative New Scandinavian Enala Study II (CONSENSUS II)
48. Force and velocity of sarcomere shortening in trabeculae from rat heart: Effect of temperature