Low-dose N(ω)-nitro-L-arginine methyl ester treatment improves survival rate and decreases myocardial injury in a murine model of viral myocarditis induced by coxsackievirus B3

Circulation Research

Volumn 81, Issue 4, 1997, Pages 504-511

  Mikami, Shuji ^a   Kawashima, Seinosuke ^a,d   Kanazawa, Kenji ^a   Hirata, Ken Ichi ^a   Hotta, Hak ^b   Hayashi, Yoshitake ^c   Itoh, Hiroshi ^c   Yokoyama, Mitsuhiro ^a  

^a First Department of Pathology   (Japan)

^b Department of Microbiology ^*  (Japan)

^c First Department of Pathology   (Japan)

^d KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

N( ) nitro L arginine methyl ester; Nitric oxide; Prostaglandin; Viral myocarditis

Indexed keywords

N(G) NITROARGININE METHYL ESTER;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; COXSACKIE VIRUS; DOSE RESPONSE; DRUG MECHANISM; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE INJURY; HISTOPATHOLOGY; MALE; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SURVIVAL RATE; VIRUS MYOCARDITIS;

EID: 0030751397     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.81.4.504     Document Type: Article

References (39)

1. Moncada S, Palmer MJ, Higgs EA. Nitric oxide: physiology pathology and pharmacology. Pharmacol Rev. 1991;43:109-141.
2. Nathan C. Nitric oxide as a secretory product ol mammalian cells. FASEB J. 1992;6:3051-3064.
3. Dinerman JL, Lowenstyein CJ, Snyder SH. Molecular mechanisms of nitric oxide regulation: potential relevance to cardiovascular disease. Circ Res. 1993;73:217-222.
4. Nathan C, Xie QW. Nitric oxide synthases: roles, tolls, and controls. Cell. 1994;78:915-918.
5. Forstermann U, Schmidt HHHW, Pollock JS. Isoforms of nitric oxide synthase. Biochem Pharmacol. 1991;42:1849-1857.
6. Hirata K, Kuroda R, Sakoda T, Katayama M, Inoue N, Suematsu M, Kawashima S, Yokoyama M. Inhibition ol endothelial nitric oxide synthase activity by protein kinase C. Hypertension. 1995;25:180-185.
7. Kanazawa K, Kawashima S, Mikami S, Miwa Y, Hirata K, Suematsu M, Hayashi Y, Itoh H, Yokoyama M. Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endotheliumdependent vascular relaxation. Am J Pathol. 1996;148:1949-1956.
8. Koide M, Kawahara Y, Nakayama I, Tsuda T, Yokoyama M. Cyclic AMP elevating agents induce an inducible type of nitric oxide synthase expression in vascular smooth muscle. J Biol Chem. 1993; 268:24959-24966.
9. Mikami S, Kawashima S, Kanazawa K, Hirata K, Katayama Y, Hotta H, Hayashi Y, Ito H, Yokoyama M. Expression of nitric oxide synthase in a murine model of viral myocarditis induced by coxsackievirus B3. Biochem Biophys Res Commun. 1996;220:983-989.
10. Estrin M, Huber SA. Coxsackievirus B3-induced myocarditis. Am J Pathol. 1987;127:335-341.
11. Woodruff JF, Woodruff JJ. Involvement of T lymphocytes in the pathogenesis of coxsackievirus B3 heart disease. J Immunol. 1974; 113:1726-1734.
12. Seko Y, Shinkai Y, Kawasaki A, Yagita H, Okumura K, Yazaki Y, Evidence of perform mediated cardiac myocyte injury in acute murine myocarditis caused by coxsackievirus B3. J Pathol. 1993;170:53-58.
13. Stamler JS, Singel DJ, Loscalzo J. Biochemistry of nitric oxide and its redox-activated form. Science. 1992;258:1898-1902.
14. Schmidt HHH, Walter U. NO at work. Cell. 1994;78:919-925.
15. Brady AJ, Wilson PA, Harding SE, Warren JB. Nitric oxide production within cardiac myocvlcs reduces their contractility in endotoxemia. Am J Pathol. 1992;263:H1963-H1966.
16. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science. 1992;257:387-389.
17. Lowenstein CJ, Hill SL, Lafond-Walker A, Wu J, Allen G, Landavere M, Rose NR, Herskowitz A. Nitric oxide inhibits viral replication in murine myocarditis. J Clin Invest. 1996;97:1837-1843.
18. Wang WZ, Matsumori A, Yamada T, Shioi T, Okada I, Matsui S, Sato Y, Suzuki H, Shiota K, Sasayama S. Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis. Circulation. 1997;95:245-251.
19. Ishiyama S, Hiroc M, Nishikawa T, Abe S, Shimojo T, Ito H, Ozawa S, Yamakawa K, Matsuzaki M, Mohammed MU, Nakazawa H, Kasajima T, Marumo F, Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats. Circulation. 1997;95:489-496.
20. Hirono S, Islam MO, Nakazawa M, Yoshida Y, Kodama M, Shibata A, Izumi T, Imai S. Expression of inducible nitric oxide synthase in rat experimental autoimmune myocarditis with special reference to changes in cardiac hemodynamics. Circ Res. 1997;80:11-20.
21. Hiraoka Y, Kishimoto C, Takada H, Sasayama S. Role of oxygen derived free radicals in the pathogenesis of coxsackievirus B3 in mice. Cardiovasc Res. 1993;27:957-961.
22. Kurihara Y, Kurihara H, Suzuki H. Kodama T, Maemura K, Nagai R, Oda H, Kuwaki T, Cao WH, Kamada N, Jishage K, Ouchi Y, Azuma S, Toyoda Y, Ishikawa T, Kumnada M, Yazaki Y. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature. l994;368:703-710.
23. Desai KM, Sato R, Sehauble E, Barsh GS, Kobilka BK, Bernstein D. Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease. Am J Physiol. 1997; 272:H1053-H1061.
24. Seibert K, Masferrer J. Role of inducible cyclooxygenase (cox-2) in inflammation. Receptor. 1994;94:17-23.
25. Salvemini D, Misko TP, Masferrer JL, Seibert MG, Currie MC, Needleman P. Nitric oxide activates eyctooxygenase enzymes. Proc Natl Acad Sci U S A. 1993;90:7240-7244.
26. Kishimoto C, Kuroki Y, Hiraoka Y, Ochiat H, Kurokawa M, Sasayama S. Cytokine and murine coxsackievirus B3 myocarditis. Circulation. 1944;89:2836-2842.
27. Woodruff JF. Viral myocarditis: a review. Am J Pathol. 1980;101:427-484.
28. Karupiah G, Xie QW, Buller RM, Nathan C, Duarte C, MacMicking JD. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase. Science. 1993;261:1445-1449.
29. Lepoivre M, Fieschi F, Coves J, Thelander L, Fontecave M. Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys Res Commun. 1991;179:442-448.
30. Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dietzschold B, Maeda H. Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc Natl Acad Sci U S A. 1996;93:2448-2453.
31. Kolb H, Kolb BV. Nitric oxide: a pathologic factor in autoimmunity. Immunol Today. 1992;13:157-160.
32. Hoffman RA, Langrehr JM, Simmons RL. The role of inducible nitric oxide synthase during graft versus host disease. Transplant Proc. 1992;24:2856.
33. McCartney-Francis N, Allen JB, Mizel DE. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med. 1993;178:744-754.
34. Stuehr DJ, Nathan CF. Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med. 1989;164:1543-1555.
35. Bookman JS, Bookman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and Superoxide. Proc Natl Acad Sci U S A. 1990;87:1620-1624.
36. Yang X, Chowdhury N, Cai B, Brett J, Marboe C, Sciacca RR, Michler RE, Cannon PJ. Induction of myocavdial nitric oxide synthase by cardiac allograft rejection. J Clin Invest. 1994;94: 714-721.
37. Balligand JL, Ungureanu D, Kelly RA, Kobzik I, Pimental D, Michel T, Smith TW. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-oonditioned medium. J Clin Invest. 1993;91:2314-2319.
38. Salvemini D, Manning PT, Zweifel BS, Selbert K, Connor J, Currie MG, Needleman P, Masferrer JL. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J Clin Invest. 1995;96:301-308.
39. Habib FM, Springall DR, Davies GJ, Oakley CM, Yacoub MH, Polak JM. Tumor necrosis factor and inducible nitric oxide symhase in dilated cardiomyopathy. Lancet. 1996;347:1151-1155.