Aspartoacylase gene knockout in the mouse: Impact on reproduction

Reproductive Toxicology

Volumn 20, Issue 2, 2005, Pages 281-283

  Surendran, Sankar ^a   Szucs, Sylvia ^a   Tyring, Stephen K ^b   Matalon, Reuben ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Aspartoacylase; Canavan disease; Fetal death; Knockout mouse; Postnatal death

Indexed keywords

ASPARTOACYLASE; AMIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANAVAN DISEASE; FEMALE; FETUS DEATH; HOMOZYGOSITY; INCIDENCE; KNOCKOUT GENE; LIFE; MALE; MATING; MOTHER; MOUSE; NEWBORN MORTALITY; NONHUMAN; PROGENY; REPRODUCTION; ANIMAL; BIOLOGICAL MODEL; DISEASE MODEL; ENZYMOLOGY; GENETICS; HOMOZYGOTE; MOUSE MUTANT; MUTATION; PATHOPHYSIOLOGY; RECESSIVE GENE;

AMIDOHYDROLASES; ANIMALS; CANAVAN DISEASE; DISEASE MODELS, ANIMAL; FETAL DEATH; GENES, RECESSIVE; HOMOZYGOTE; MICE; MICE, KNOCKOUT; MODELS, GENETIC; MUTATION; REPRODUCTION;

EID: 19444378805     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2005.02.001     Document Type: Article

References (17)

1. M.M. Canavan Schilder's encephalitis perioxalis diffusa Neurology 15 1931 299 308
2. L. van Bogaert, and I. Bertrand Sur une idiotie familiale avec degenerescence spongieuse de neuraxe (note preliminaire) Acta Neurol Belg 49 1949 572 587
3. R. Kaul, K. Balamurugan, G.P. Gao, and R. Matalon Canavan disease: genomic organization and localization of human ASPA to 17p13-ter: conservation of the ASPA gene during evolution Genomics 21 1994 364 370
4. R. Matalon, K. Michals, D. Sebesta, M. Deanching, P. Gashkoff, and J. Casanova Aspartoacylase deficiency and N-acetyl-aspartic aciduria in patients with Canavan disease Am J Med Genet 29 1988 463 471
5. S.M. Birnbaum Aminoacid acylases I and II from hog kidney Methods Enzymol 2 1955 115 119
6. R. Matalon Canavan disease: diagnosis and molecular analysis Genet Test 1 1997 21 25
7. S. Surendran, K. Michals-Matalon, and M.J. Quast Canavan disease: a monogenic trait with complex genomic interaction Mol Genet Metab 80 2003 74 80
8. R. Matalon, P.L. Rady, and K.A. Platt Knock-out mouse for canavan disease: a model for gene transfer to the central nervous system J Gene Med 2 2000 165 175
9. Surendran S, Matalon R. Progress in Canavan disease. The Science Advisory Board 2004, at: http://www.scienceboard.net/community/perspectives.108.html.
10. S. Surendran, P.L. Rady, and K. Matalon Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knockout mouse for Canavan disease Brain Res Bull 61 2003 427 435
11. S. Surendran, K. Matalon, S. Szucs, S.K. Tyring, and R. Matalon Metabolic changes in the knockout mouse for Canavan's disease: implications for patients with Canvans disease J Child Neurol 18 2003 611 615
12. S. Surendran, E.L. Ezell, M.J. Quast, J. Wei, S.K. Tyring, and K. Matalon Mental retardation and hypotonia seen in the knockout mouse for Canavan disease is not due to succinate semialdehyde dehydrogenase deficiency Neurosci lett 358 2004 29 32
13. S. Surendran, G.A. Campbell, S.K. Tyring, and R. Matalon Aspartoacylase gene knockout results in severe vacuolation in the white matter and gray matter of the spinal cord in the mouse Neurobiol Dis 18 2005 385 389
14. S. Surendran, K.M. Matalon, S.K. Tyring, and R. Matalon Molecular basis of Canavan's disease: from human to mouse J Child Neurol 18 2003 604 610
15. R. Matalon, P. Rady, and S. Surendran Delivery of rAAV-aspartoacylase in knock out mouse for Canavan disease J Inherit Metab Dis Suppl. 1 2001 123
16. R. Matalon, S. Surendran, and P.L. Rady Adeno-associated virus mediated aspartoacylase gene transfer to the brain of knock out mouse for Canavan disease Mol Ther 7 2003 580 587
17. P. Leone, C.G. Janson, and L. Bilaniuk Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease Ann Neurol 48 2000 27 38