Enterococcus faecalis sex pheromone plasmid pAM373: Analyses of TraA and evidence for its interaction with RpoB

Plasmid

Volumn 54, Issue 1, 2005, Pages 57-69

  Ozawa, Yoshiyuki ^a,c   De Boever, Erika H ^a,d   Clewell, Don B ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Conjugation; Enterococcus faecalis; pAM373; Pheromone; Plasmid; TraA

Indexed keywords

BACTERIAL PROTEIN; RIFAMPICIN; RNA POLYMERASE BETA SUBUNIT; SEX PHEROMONE;

ANTIBIOTIC RESISTANCE; ARTICLE; ENTEROCOCCUS FAECALIS; GENETIC TRANSCRIPTION; MOLECULAR CLONING; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PROMOTER REGION; PROTEIN INTERACTION; TRANSPOSON; WILD TYPE;

BACTERIAL PROTEINS; BASE SEQUENCE; CODON, TERMINATOR; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI PROTEINS; FIMBRIAE PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; MUTATION; PHEROMONES; PLASMIDS; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; RIFAMPIN;

ENTEROCOCCUS FAECALIS;

EID: 19444368458     PISSN: 0147619X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plasmid.2004.12.003     Document Type: Article

References (40)

1. F.Y. An, and D.B. Clewell Identification of the cAD1 sex pheromone precursor in Enterococcus faecalis J. Bacteriol. 184 2002 1880 1887
2. F.Y. An, M.C. Sulavik, and D.B. Clewell Identification and characterization of a determinant (eep) on the Enterococcus faecalis chromosome that is involved in production of the peptide sex pheromone cAD1 J. Bacteriol. 181 1999 5915 5921
3. F.M. Ausubel, F.M. Brent, R.E. Kingston, D.D. Moor, J.G. Seidman, J.A. Smith, and K. Struhl Current Protocols in Molecular Biology 1987 Wiley New York
4. T. Bae, S. Clerc-Bardin, and G.M. Dunny Analysis and expression of prgX, a key negative regulator of the transfer of the Enterococcus faecalis pheromone-inducible plasmid pCF10 J. Mol. Biol. 297 2000 861 875
5. T. Bae, B. Kozlowicz, and G.M. Dunny Two targets in pCF10 DNA for PrgX binding: their role in production of Qa and prgX mRNA and in regulation of pheromone-inducible conjugation J. Mol. Biol. 315 2002 995 1007
6. M.C.F. Bastos, H. Tomita, K. Tanimoto, and D.B. Clewell Regulation of the Enterococcus faecalis pAD1-related sex pheromone response: analyses of traD expression and its role in controlling conjugation functions Mol. Microbiol. 30 1998 381 392
7. M.S. Brown, J. Ye, R.B. Rawson, and J.L. Goldstein Regulated intramembrane proteolysis; a control mechanism conserved from bacteria to humans Cell 100 2000 391 398
8. D.B. Clewell Sex pheromone system in enterococci G.M. Dunny S.C. Winans Cell-Cell Signaling in Bacteria 1999 ASM Press Washington, DC 47 65
9. D.B. Clewell, F.Y. An, B.A. White, and C. Gawron-Burke Streptococcus faecalis sex pheromone (cAM373) also produced by Staphylococcus aureus and identification of a conjugative transposon (Tn918) J. Bacteriol. 162 1985 1212 1220
10. D.B. Clewell, F.Y. An, S.F. Flannagan, M. Antiporta, and G.M. Dunny Enterococcal sex pheromone precursors are part of signal sequences for surface lipoproteins Mol. Microbiol. 35 2000 246 247
11. D.B. Clewell, and G.M. Dunny Conjugation and genetic exchange in enterococci M. Gilmore D.B. Clewell P. Courvalin G.M. Dunny B.E. Murray L.B. Rice The Enterococci: Pathogenesis, Molecular Biology, and Antibiotic Resistance 2002 ASM Press Washington, DC 265 300
12. D.B. Clewell, and M.V. Francia Conjugation in Gram-positive bacteria B.E. Funnell G.J. Phillips Plasmid Biology 2004 ASM Press Washington, DC 227 256
13. D.B. Clewell, P.K, M.C. Gawron-Burke, A.E. Franke, Y. Yagi, and F.Y. An Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917 J. Bacteriol. 152 1982 1220 1230
14. De Boever, E.H., 2001. Genetic and transcriptional analyses of the pheromone response of the Enterococcus faecalis plasmid pAM373. Ph. D. Dissertation. The University of Michigan, Ann Arbor
15. E.H. De Boever, D.B. Clewell, and C.M. Fraser Enterococcus faecalis conjugative plasmid pAM373: complete nucleotide sequence and genetic analyses of sex pheromone response Mol. Microbiol. 37 2000 1327 1341
16. G.M. Dunny, B.L. Brown, and D.B. Clewell Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone Proc. Natl. Acad. Sci. USA 75 1978 3479 3483
17. S.E. Flannagan, J.W. Chow, S.M. Donabedian, W.J. Brown, M.B. Perri, M.J. Zervos, Y. Ozawa, and D.B. Clewell Plasmid content of a vancomycin-resistant Enterococcus faecalis isoloate from a patient also colonized by Staphylococcus aureus with a VanA phenotype Antimicrob. Agents Chemother. 47 2003 3954 3959
18. S.E. Flannagan, and D.B. Clewell Conjugative transfer of Tn916 in Enterococcus faecalis: trans activation of homologous transposons J. Bacteriol. 173 1991 7136 7141
19. S.E. Flannagan, and D.B. Clewell Identification and characterization of genes encoding sex pheromone cAM373 activity in Enterococcus faecalis and Staphylococcus aureus Mol. Microbiol. 44 2002 803 817
20. M.V. Francia, and D.B. Clewell Amplification of the tetracycline- resistance determinant of pAMα1 in Enterococcus faecalis requires a site specific recombination event involving relaxase J. Bacteriol. 184 2002 5187 5193
21. A.E. Franke, and D.B. Clewell Evidence for a chromosome-borne resistance transposon (Tn916) in Streptococcus faecalis that is capable of "conjugal" transfer in the absence of a conjugative plasmid J. Bacteriol. 145 1981 494 502
22. S. Fujimoto, and D.B. Clewell Regulation of the pAD1 sex pheromone response of Enterococcus faecalis by direct interaction between the cAD1 peptide mating signal and the negatively regulating, DNA-binding TraA protein Proc. Natl. Acad. Sci. USA 95 1998 6430 6435
23. M.M. Huycke, D.F. Sahm, and M.S. Gilmore Multiple-drug resistant enterococci: the nature of the problem and an agenda for the future Emerg. Infect. Dis. 4 1998 239 249
24. Y. Ike, and D.B. Clewell Genetic analysis of the pAD1 pheromone response in Streptococcus faecalis, using transposon Tn917 as an insertional mutagen J. Bacteriol. 158 1984 777 783
25. A.E. Jacob, and S. Hobbs Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes J. Bacteriol. 117 1974 360 372
26. V. Kak, and J.W. Chow Acquired antibiotic resistances in enterococci M. Gilmore D.B. Clewell P. Courvalin G.M. Dunny B.E. Murray L.B. Rice The Enterococci: Pathogenesis, Molecular Biology, and Antibiotic Resistance 2002 ASM Press Washington, DC 335 383
27. B.A.B. Leonard, A. Podbielski, P.J. Hedberg, and G.M. Dunny Enterococcus faecalis pheromone binding protein, PrgZ, recruits a chromosomal oligopeptide permease system to import sex pheromone cCF10 for induction of conjugation Proc. Natl. Acad. Sci. USA 93 1996 260 264
28. A. Muscholl-Silberhorn Cloning and functional analysis of Asa373, a novel adhesin unrelated to the other sex pheromone plasmid-encoded aggregation substances of Enterococcus faecalis Mol. Microbiol. 34 1999 620 630
29. J. Nakayama, G.M. Dunny, D.B. Clewell, and A. Suzuki Quantitative analysis for pheromone inhibitor and pheromone shutdown in Enterococcus faecalis J.J. Ferretti M.S. Gilmore T.R. Klaenhammer F. Brown Genetics of Streptococci, Enterococci and Lactococci. Developmental and Biological Standards vol. 85 1995 Karger Basel, Switzerland 35 38
30. J. Nakayama, S. Igarashi, H. Nagasawa, D.B. Clewell, F.Y. An, and A. Suzuki Isolation and structure of staph-cAM373 produced by Staphylococcus aureus that induces conjugal transfer of Enterococcus faecalis plasmid pAM373 Biosci. Biotech. Biochem. 59 1996 1358 1359
31. L.T. Pontius, and D.B. Clewell Regulation of the pAD1-encoded sex pheromone response in Enterococcus faecalis: nucleotide sequence analysis of traA J. Bacteriol. 174 1992 1821 1827
32. S.A. Showsh, E.H. De Boever, and D.B. Clewell Vancomycin resistance plasmid in Enterococcus faecalis that encodes sensitivity to a sex pheromone also produced by Staphylococcus aureus Antimicrob. Agents Chemother. 45 2001 2177 2178
33. K. Tanimoto, and D.B. Clewell Regulation of the pAD1-encoded sex pheromone response in Enterococcus faecalis: expression of the positive regulator traE1 J. Bacteriol. 175 1993 1008 1018
34. P. Tomich, F.Y. An, and D.B. Clewell Properties of an erythromycin inducible transposon (Tn917) in Streptococcus faecalis J. Bacteriol. 141 1980 1366 1374
35. H. Tomita, and D.B. Clewell A pAD1-encoded small RNA molecule, mD, negatively regulates Enterococcus faecalis pheromone response by enhancing transcription termination J. Bacteriol. 182 2000 1062 1073
36. A.J. Vogler, J.D. Busch, S. Percy-Fine, C. Tipton-Hunton, K.L. Smith, and P. Keim Molecular analysis of rifampin resistance in Bacillus anthracis and Bacillus cereus Antimicrob. Agents Chemother. 46 2002 511 513
37. K.E. Weaver, and D.B. Clewell Regulation of the pAD1 sex pheromone response in Enterococus faecalis: construction and characterization of lacZ transcriptional fusions in a key control region of the plasmid J. Bacteriol. 170 1988 4343 4352
38. K.E. Weaver, and D.B. Clewell Control of Enterococcus faecalis sex pheromone cAD1 elaboration: effects of culture aeration and pAD1 plasmid-encoded determinants Plasmid 25 1991 177 189
39. L.M. Weigel, D.B. Clewell, S.R. Gill, N.C. Clark, L.K. McDougal, S.E. Flannagan, J.F. Kolonay, J. Shetty, G.E. Kilgore, and F.C. Tenover Molecular analysis of a clinical isolate of Staphylococcus aureus with high-level resistance to vancomycin Science 302 2003 1569 1571
40. R. Wirth, F.Y. An, and D.B. Clewell Highly efficient protoplast transformation system for Streptococcus faecalis and an Escherichia coli-S. faecalis shuttle vector J. Bacteriol. 165 1986 831 836