Glycogen Synthase Kinase 3β as a Likely Target for the Action of Lithium on Circadian Clocks

Chronobiology International

Volumn 21, Issue 1, 2004, Pages 43-55

  Padiath, Quasar Saleem ^a   Paranjpe, Dhanashree ^b   Jain, Sanjeev ^c   Sharma, Vijay Kumar ^b  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^c NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Circadian rhythms; Drosophila melanogaster; GSK 3 ; Lithium; Period elongation

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM;

ARTICLE; BIPOLAR DISORDER; CIRCADIAN RHYTHM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DARKNESS; DOWN REGULATION; DROSOPHILA MELANOGASTER; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; FEMALE; LOCOMOTION; LONG TERM CARE; MALE; MENTAL PATIENT; MOOD; NONHUMAN; PATHOGENESIS; PHYSICAL ACTIVITY; PROTEIN TARGETING;

ANIMALS; ARMADILLO DOMAIN PROTEINS; BETA CATENIN; BIOLOGICAL CLOCKS; BIPOLAR DISORDER; CIRCADIAN RHYTHM; CYTOSKELETAL PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LITHIUM; MALE; MOTOR ACTIVITY; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 1942531414     PISSN: 07420528     EISSN: None     Source Type: Journal    
DOI: 10.1081/CBI-120027981     Document Type: Article

References (38)

1. Benedetti, F., Barbini, B., Campori, E., Fulgosi, M. C., Pontiggia, A., Colombo, C. (2001). Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model? J. Psychiatr. Res. 35:323-329.
2. Bier, E., Reiter, L. T. (2002). Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. Expert. Opin. Ther. Targets 6:387-399.
3. Cadigan, K. M., Nusse, R. (1997). Wnt signaling: a common theme in animal development. Genes Dev. 11:3286-3305.
4. Chen, G., Huang, L. D., Jiang, Y. M., Manji, H. K. (1999). The mood-stabilizing agent valproate inhibits the activity of Glycogen Synthase Kinase-3β. J. Neurochem. 72:1327-1330.
5. Cohen, P., Frame, S. (2001). The renaissance of GSK3. Nat. Rev. Mol. Cell Biol. 2:769-776.
6. Detera-Wadleigh, S. D. (2001). Lithium-related genetics of bipolar disorder. Ann. Med. 33:272-285.
7. Fortini, M. E., Bonini, N. M. (2000). Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer. Trends Genet. 16:161-167.
8. Goodwin, F. K., Jamison, K. R. (1990). Manic-Depressive Illness. New York: Oxford University Press.
9. Goodwin, F. K., Wirz-Justice, A., Wehr, T. A. (1982). Evidence that the pathophysiology of depression and the mechanism of drug action of anti-depressant drugs both involve alterations in circadian rhythms. In: Costa, E., Racagni, G., eds. Typical and Atypical Anti-Depressants: Clinical Practice. New York: Raven Press, pp. 1-11.
10. Gould, T. D., Manji, H. K. (2002). The Wnt signaling pathway in bipolar disorder. Neuroscientist 8:497-511.
11. Hall, A. C., Lucas, F. R., Salinas, P. C. (2000). Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signalling. Cell 100:525-535.
12. Hall, A. C., Brennan, A., Goold, R. G., Cleverley, K., Lucas, F. R., Gordon-Weeks, P. R., Salinas, P. C. (2002). Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons. Mol. Cell Neurosci. 20:257-270.
13. Helfrich-Förster, C. (2000). Differential control of morning and evening components in the activity rhythm of Drosophila melanogaster-sex-specific differences suggest a different quality of activity. J. Biol. Rhythms 15:135-154.
14. Jain, S. (1995). The biology of mania. In: Koslow, S., Murthy, R. S., eds. The Decade of the Brain. Bangalore: ADAMHA-NIMHANS.
15. Johnsson, A., Engelmann, W., Pflug, B., Klemke, W. (1983). Period lengthening of human circadian rhythms by lithium carbonate, a prophylactic for depressive disorders. Int. J. Chronobiol. 8:129-147.
16. Jope, R. S. (1999). Anti-bipolar therapy: mechanism of action of lithium. Mol. Psychiatry 4:117-128.
17. Klein, P. S., Melton, D. A. (1996). A molecular mechanism for the effect of lithium on development. Proc. Nad. Acad. Sci. USA 93:8455-8459.
18. Klemfuss, H. (1992). Rhythms and the pharmacology of lithium. Pharmacol. Ther. 56:53-78.
19. Kozlovsky, N., Belmaker, R. H., Agam, G. (2002). GSK-3 and the neurodevelopmental hypothesis of schizophrenia. Eur. Neuropsychopharmacol. 12:13-25.
20. Lenox, R. H., Gould, T. D., Manji, H. K. (2002). Endophenotypes in bipolar disorder. Am. J. Med. Genet. 114:391-406.
21. Li, X., Bijur, G. N., Jope, R. S. (2002). Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection. Bipolar. Disord. 4:137-144.
22. Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C. X., Herrup, K, Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., Wynshaw-Boris, A. (1997). Social interaction and sensorimotor gating abnormalities in mice lacking. Dvll. Cell 90:895-905.
23. Lucas, F. R., Goold, R. G., Gordon-Weeks, P. R., Salinas, P. C. (1998). Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. J. Cell Sci. 111:1351-1361.
24. Lucas, F. R., Salinas, P. C. (1997). WW-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Dev. Biol. 192:31-44.
25. Martinek, S., Inonog, S., Manoukian, A. S., Young, M. W. (2001). A role for the segment polarity gene shaggy/GSK 3 in the Drosophila circadian clock. Cell 105:769-779.
26. Moore, M. S., DeZazzo, J., Luk, A. Y., Tully, T., Singh, C. M., Heberlein, U. (1998). Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93:997-1007.
27. Panda, S., Hogenesch, J. B., Kay, S. A. (2002). Circadian rhythms from flies to human. Nature 417:329-335.
28. Patapoutian, A., Reichardt, L. F. (2000). Roles of Wnt proteins in neural development and maintenance. Curr. Opin. Neurobiol. 10:392-399.
29. Peifer, M., Sweeton, D., Casey, M., Wieschaus, E. (1994). Wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120:369-380.
30. Plyte, S. E., Hughes, K., Nikolakaki, E., Pulverer, B. J., Woodgett, J. R. (1992). Glycogen synthase kinase-3: functions in oncogenesis and development. Biochim. Biophys. Acta. 1114:147-162.
31. Ruel, L., Stambolic, V., Ali, A., Manoukian, A. S., Woodgett, J. R. (1999). Regulation of the protein kinase activity of Shaggy (Zeste-white3) by components of the Wingless pathway in Drosophila cells and embryos. J. Biol. Chem. 274:21790-21796.
32. Sharma, V. K. (2003). A simple computer-aided device for monitoring activity of small mammals and insects. Biol. Rhythm Res. 34:3-12.
33. Sheeba, V., Chandrashekaran, M. K., Joshi, A., Sharma, V. K. (2002). Locomotor activity rhythm in Drosophila melanogaster after 600 generations in an aperiodic environment. Naturwissenschaften 86:448-449.
34. Stambolic, V., Ruel, L., Woodgett, J. R. (1996). Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells. Curr. Biol. 6:1664-1668.
35. Tickoo, S., Russell, S. (2002). Drosophila melanogaster as a model system for drug discovery and pathway screening. Curr. Opin. Pharmacol. 2:555-560.
36. Wehr, T. A., Wirz-Justice, A., Goodwin, F. K., Duncan, W., Gillin, J. C. (1979). Phase advance of the circadian sleep-wake cycle as an antidepressant. Science 206:710-713.
37. Williams, R. S., Cheng, L., Mudge, A. W., Harwood, A. J. (2002). A common mechanism of action for three mood-stabilizing drugs. Nature 417:292-295.
38. Williams, R. S., Harwood, A. J. (2000). Lithium therapy and signal transduction. Trends Pharmacol. Sci. 21:61-64.