The phase I biotransformation of the potential antileukotrienic drug quinlukast in rat microsomes and hepatocytes

Collection of Czechoslovak Chemical Communications

Volumn 69, Issue 3, 2004, Pages 689-702

  Wsól, Vladimír ^a   Szotáková, Barbora ^a   Baliharová, Vendula ^a   Šišpera, Luděk ^a   Holčapek, Michal ^b   Kolářová, Lenka ^b   Suchanová, Bohumila ^a   Kuchař, Miroslav ^c   Skálová, Lenka ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF PARDUBICE   (Czech Republic)

^c Research Institute of Pharmacy and Biochemistry Prague   (Czech Republic)

Author keywords

Antiasthmatics; Antihistaminics; Biotransformations; Drug metabolism; Enzyme kinetics; Hepatocytes; Kinetic parameters; LC MS; Metabolic pathways; Metabolites; Microsomes

Indexed keywords

ANTIASTHMATIC AGENT; QUINLUKAST; SULFONE; SULFOXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CALCULATION; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG METABOLISM; DRUG POTENTIATION; DRUG TRANSFORMATION; EVALUATION; IN VITRO STUDY; INCUBATION TIME; LIVER CELL; LIVER CYTOSOL; MALE; MICROSOME; NONHUMAN; RAT; STANDARD;

EID: 1942518847     PISSN: 00100765     EISSN: None     Source Type: Journal    
DOI: 10.1135/cccc20040689     Document Type: Article

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