Metabolism and excretion of zafirlukast in dogs, rats, and mice

Drug Metabolism and Disposition

Volumn 26, Issue 11, 1998, Pages 1069-1076

  Savidge, R D ^a   Bui, K H ^b   Birmingham, B K ^b   Morse, J L ^b   Spreen, R C ^b  

^a ASTRAZENECA   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ZAFIRLUKAST;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG DETERMINATION; DRUG EXCRETION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG SCREENING; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-ASTHMATIC AGENTS; BIOTRANSFORMATION; BODY FLUIDS; DOGS; FECES; FEMALE; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; TOSYL COMPOUNDS;

ANIMALIA; CANIS FAMILIARIS;

EID: 0031739603     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Samuelsson B (1983) Leukotrienes: mediators of immediate hypertensitivity reactions and inflammation. Science (Washington DC) 220:568-575.
2. Spreen RC (1994) Direct analysis of ICI 204,219 metabolites in biological samples by HPLC/ electrospray and MS and HPLC/MS/MS with radioactivity detection, in Proceedings of the 42nd American Society of Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, p 360, American Society of Mass Spectrometry, Chicago.
3. Wenzel S (1997) Arachidonic acid metabolites: mediators of inflammation in asthma. Pharmacotherapy 17:3S-12S.