A specialist herbivore (Neotoma stephensi) absorbs fewer plant toxins than does a generalist (Neotoma albigula)

Physiological and Biochemical Zoology

Volumn 77, Issue 1, 2004, Pages 139-148

  Sorensen, J S ^a,b   Turnbull, C A ^a   Dearing, M D ^a  

^a UNIVERSITY OF UTAH   (United States)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA-PINENE; PINENE; TERPENE;

DETOXIFICATION; GENERALIST; HERBIVORE; RODENT; SPECIALIST;

ADAPTATION; ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BODY WEIGHT; CHEMISTRY; COMPARATIVE STUDY; DIET; EATING; FECES; GAS CHROMATOGRAPHY; JUNIPERUS; METABOLISM; MURIDAE; PHYSIOLOGY; UNITED STATES;

ADAPTATION, PHYSIOLOGICAL; ANALYSIS OF VARIANCE; ANIMALS; ARIZONA; BODY WEIGHT; CHROMATOGRAPHY, GAS; DIET; EATING; FECES; JUNIPERUS; MONOTERPENES; MURIDAE;

ANIMALIA; JUNIPERUS; JUNIPERUS MONOSPERMA; MAMMALIA; MURIDAE; NEOTOMA; NEOTOMA ALBIGULA; NEOTOMA STEPHENSI; RODENTIA;

EID: 1942518316     PISSN: 15222152     EISSN: None     Source Type: Journal    
DOI: 10.1086/378923     Document Type: Article

References (61)

1. Adams R.P. 1994. Geographic variation in the volatile terpenoids of Juniperus monosperma and J. osteosperma. Biochem Syst Ecol 22:65-71.
2. Appendino G., C. Porta, G. Conseil, O. Sterner, E. Mercalli, C. Dumontet, and A. Di Peitro. 2003. A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris). J Nat Prod 66:140-142.
3. Austin P.J., L.A. Suchar, C.T. Robbins, and A.E. Hagerman. 1989. Tannin-binding proteins in saliva of deer and their absence in saliva of sheep and cattle. J Chem Ecol 15:1335-1347.
4. Bellamy W.T. 1996. P-glycoproteins and multidrug resistance. Annu Rev Pharmacol Toxicol 36:161-183.
5. Bhat T.K., B. Singh, and O.P. Sharma. 1998. Microbial degradation of tannins: a current perspective. Biodegradation 9:343-357.
6. Boyle R., S. McLean, and N.W. Davies. 2000. Biotransformation of 1,8-cineole in the brushtail possum (Trichosurus vulpecula). Xenobiotica 30:915-932.
7. Boyle R., S. McLean, W.J. Foley, and N.W. Davies. 1999. Comparative metabolism of dietary terpene, p-cymene, in generalist and specialist folivorous marsupials. J Chem Ecol 25:2109-2127.
8. Burns J.H., ed. 1972. Analytical Profiles of Drug Substances. Academic Press, New York.
9. Chavez D., B. Cui, H. Chai, R. Garcia, M. Mejia, N.R. Farnsworth, G.A. Cordell, J.M. Pezzuto, and A.D. Kinghorn. 2002. Reversal of multidrug resistance by tropane alkaloids from the stems of Erythroxylum rotundifolium. J Nat Prod 64:606-610.
10. Cotler S., C.J. Bugge, and W.A. Colburn. 1983. Role of gut contents, intestinal wall, and liver on the first pass metabolism and absolute bioavailability of isotretinoin in the dog. Drug Metab Dispos 11:458-462.
11. Davies B. and T. Morris. 1993. Physiological parameters in laboratory animals and humans. Pharm Res 10:1093-1095.
12. Dearing M.D., A.M. Mangione, and W.H. Karasov. 2000. Diet breadth of mammalian herbivores: tests of the nutrient constraints and detoxification- limitations hypotheses. Oecologia 123:397-405.
13. _. 2002. Ingestion of plant secondary compounds causes diuresis in desert woodrats. Oecologia 130:576-584.
14. Debenham P., N. Kartner, L. Siminovitch, J. Riordan, and V. Ling. 1982. DNA mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression. Mol Cell Biol 2:881-889.
15. Dial K.P. 1988. Three sympatric species of Neotoma: dietary specialization and coexistence. Oecologia 76:531-537.
16. Eberhard I.H., J. McNamara, R.J. Pearse, and I.A. Southwell. 1975. Ingestion and excretion of Eucalyptus puntata D.C. and its essential oil by the koala Phascolarctos cinereus. Aust J Zool 23:169-179.
17. Edwards C.W. and R.D. Bradley. 2002. Molecular systematics of the genus Neotoma. Mol Phylogenet Evol 25:489-500.
18. Falk A.A., E. Gullstrand, A. Lof, and E. Wigaeus-Hjelm. 1990a. Liquid/air partition coefficients of four terpenes. Br J Ind Med 47:62-64.
19. Falk A.A., M.T. Hagberg, A.E. Lof, E.M. Wigaeus-Hjelm, and W. Zhiping. 1990b. Uptake, distribution and elimination of alpha-pinene in man after exposure by inhalation. Scand J Work Environ Health 16:372-378.
20. Foley J.W., G.R. Iason, and C. McArthur. 1999. Role of plant secondary metabolites in the nutritional ecology of mammalian herbivores: how far have we come in 25 years? Pp. 130-209 in H.G. Jung and G.C. Fahey, eds. Nutritional Ecology of Herbivores. American Society of Animal Science, Savoy, Ill.
21. Foley W.J., E.V. Lassak, and J. Brophy. 1987. Digestion and absorption of Eucalyptus essential oils in greater glider (Petauroides volans) and brushtail possums (Trichosurus vulpecula). J Chem Ecol 13:2115-2130.
22. Freeland W.J. 1991. Plant secondary metabolites. Biochemical evolution with herbivores. Pp. 61-82 in R. Palo and C. T. Robbins, eds. Plant Defenses Against Mammalian Herbivory. CRC, Boca Raton, Fla.
23. Freeland W.J. and D.H. Janzen. 1974. Strategies in herbivory by mammals: the role of plant secondary compounds. Am Nat 108:269-289.
24. George C.F. 1981. Drug metabolism by the gastrointestinal mucosa. Clin Pharmacokinet 6:259-274.
25. Gleeson D. 1992. Acid-base transport systems in gastrointestinal epithelia. Gut 33:1134-1145.
26. Hall S., K. Thummel, P. Watkins, K. Lown, L. Benet, M. Paine, R. Mayo, et al. 1999. Molecular and physical mechanisms of first-pass extraction. Drug Metab Dispos 27:161-166.
27. Hartiala K. 1973. Metabolism of hormones, drugs, and other substances by the gut. Physiol Rev 53:496-534.
28. Hedenstierna G., R. Alexanderson, K. Wimander, and G. Rosen. 1983. Exposure to terpenes: effects on pulmonary function. Int Arch Occup Environ Health 51:191-198.
29. Hedman R. and H. Pettersson. 1997. Transformation of nivalenol by gastrointestinal microbes. Arch Anim Nutr 50:321-329.
30. Hohmann J., J. Molnar, D. Redei, F. Evanics, P. Forgo, A. Kalman, G. Argay, and P. Szabo. 2002. Discovery and biological evaluation of a new family of potent modulators ofmultidrug resistance: reversal of multidrug resistance of mouse lymphoma cells by new natural jatrophane diterpenoids isolated from Euphorbia species. J Med Chem 45:2425-2431.
31. Hunter J. and B. Hirst. 1997. Intestinal secretion of drugs: the role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption. Adv Drug Delivery Rev 25:129-157.
32. Hwang B.Y., S.E. Kim, Y.O. Kim, Y. Hong, J.S. Ro, K.S. Lee, and J.J. Lee. 1999. Pregnane glycoside multidrug-resistance modulators from Cynanchum wilfodii. J Nat Prod 62:640-643.
33. Igimi H. and M. Nishimura. 1974. Studies on the metabolism of d-limonene (p-Mentha-1,8-diene). I. The absorption, distribution, and excretion of d-limonene in rats. Xenobiotica 4:77-84.
34. Ilett K., L. Tee, P. Reeves, and R. Minchin. 1993. Metabolism of drugs and other xenobiotics in the gut lumen and wall. Pharmacol Ther 46:67-93.
35. Juliano R. and V. Ling. 1976. A surface glycoprotein modulating drug permeability in chinese hamster ovary cell mutants. Biochim Biophys Acta 455:152-162.
36. Kartner N., J. Fiordan, and V. Ling. 1983. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 221:1285-1288.
37. Kiessling K.H., H. Pettersson, K. Sandholm, and M. Olsen. 1984. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Appl Environ Microbiol 47:1070-1073.
38. Kim S.E., H.S. Kim, Y.S. Hong, Y.C. Kim, and J.J. Lee. 1999. Sesquiterpene esters from Celastrus orbiculatus and their structure-activity relationship on the modulation of multidrug-resistance. J Nat Prod 62:697-700.
39. Lawler I.R., W.J. Foley, B.M. Eschler, D.M. Pass, and K. Handasyde. 1998. Intraspecific variation in Eucalyptus secondary metabolites determines food intake by folivorous marsupials. Oecologia 116:160-169.
40. Lawler I.R., D.M. Schliebs, B.M. Eschler, and W.J. Foley. 1999. Relationship between chemical functional groups on Eucalyptus secondary metabolites and their effectiveness as marsupial antifeedants. J Chem Ecol 25:2561-2573.
41. McArthur C. and G.D. Sanson. 1991. Effects of tannins on digestion in the common ringtail possum (Pseudocheirusperegrinus), a specialized marsupial folivore. J Zool (Lond) 225:233-252.
42. Mehansho H., L.G. Butler, and D.M. Carlson. 1987. Dietary tannins and salivary proline-rich proteins: interactions, induction and defense mechanisms. Annu Rev Nutr 7:423-440.
43. Muller M., C. Meijer, G. Zaman, P. Borst, R. Scheper, N. Mulder, E. De Vries, and P. Jansen. 1994. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91:13033-13037.
44. O'Brien T., A. Lomdahl, and G. Sanson. 1986. Preliminary microscopic investigations of the digesta derived from foliage of Eucalyptus ovata (Labill.) in the digestive tract of the common ringtail possum, Pseudocheirusperegrinus (Marsupialia). Aust J Zool 34:157-176.
45. Osawa R. 1990. Formation of a clear zone on tannin-treated brain heart infusion agar by a Streptococcus sp. isolated from the feces of koalas. Appl Environ Microbiol 56:829-831.
46. Penzotti J.E., M.L. Lamb, E. Evensen, and P.D.J. Grootenhuis. 2002. A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein. J Med Chem 45:1737-1740.
47. Robbins C.T., A.E. Hagerman, P.J. Austin, C. McArthur, and T.A. Hanley. 1991. Variation in mammalian physiological responses to a condensed tannin and its ecological implications. J Mammal 72:480-486.
48. Savolainen H. and P. Pfaffli. 1978. Effects of longterm turpentine inhalation on rat brain protein metabolism. Chem-Biol Interact 21:271-276.
49. Schinkel A.H. and J.W. Jonker. 2003. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family, an overview. Adv Drug Delivery Rev 55:3-29.
50. Sharom F. 1997. The P-glycoprotein efflux pump: how does it transport drugs? J Membr Biol 160:161-175.
51. Silverman J.A. 1999. Multidrug-resistance transporters. Pharm Biotechnol 12:353-386.
52. Sorensen J.S. and M.D. Dearing. 2003. Elimination of plant toxins: an explanation for dietary specialization in mammalian herbivores. Oecologia 134:88-94.
53. Sparreboom A., J. Van Asperen, U. Mayer, A.H. Schinkel, J.W. Smit, D.K.F. Meijer, P. Borst, W.J. Nooijen, J.H. Beijnen, and O. van Tellingen. 1997. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 94:2031-2035.
54. Sperling F., W.L. Marcus, and C. Collins. 1967. Acute effects of turpentine vapor on rats and mice. Toxicol Appl Pharmacol 10:8-20.
55. Vaughan T.A. 1982. Stephen's woodrat, a dietary specialist. J Mammal 63:53-62.
56. Wang E., K. Lew, M. Barecki, C.N. Casciano, R.P. Clement, and W.W. Johnson. 2001. Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol 14:1596-1603.
57. Washington N., C. Washington, and C.G. Wilson. 2001. Physiological Pharmaceutics: Barriers to Drug Absorption. Taylor & Francis, New York.
58. Watkins P.B. 1997. The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv Drug Delivery Rev 27:161-170.
59. Zaman G., M. Flens, M. van Leusden, M. De Haas, H. Mulder, J. Lankelma, H. Pinedo, et al. 1994. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci USA 91:8822-8826.
60. Zamora J.M., H.L. Pearce, and W.T. Beck. 1988. Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Mol Pharmacol 33:454-462.
61. Zhang L., C. Brett, and K. Giacomini. 1998. Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol 38:431-460.