NPY presynaptic actions are reduced in the hypothalamic mpPVN of obese (fa/fa), but not lean, Zucker rats in vitro

British Journal of Pharmacology

Volumn 141, Issue 6, 2004, Pages 1032-1036

  Pronchuk, Nina ^a   Colmers, William F ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

BIBP3226; Brain slice; Females; GABAergic transmission; Hypothalamus; Neuropeptide Y; Obesity; Patch clamp recordings; Presynaptic inhibition; Y 1 receptor; Y 5 receptor; Zucker rat

Indexed keywords

4 AMINOBUTYRIC ACID; [2 NITROBENZENE SULFONIC ACID [4 (2 NAPHTHYLMETHYLAMINO)METHYL]CYCLOHEXYLMETHYL]AMIDE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; BRAIN SLICE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; EATING HABIT; FEMALE; GABAERGIC TRANSMISSION; INHIBITORY POSTSYNAPTIC POTENTIAL; LEAN BODY WEIGHT; NONHUMAN; OBESITY; PATCH CLAMP; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SYNAPSE;

ANIMALS; EATING; ELECTROPHYSIOLOGY; FEMALE; MEMBRANE POTENTIALS; NEURONS; NEUROPEPTIDE Y; OBESITY; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RECEPTORS, GABA-A; RECEPTORS, NEUROPEPTIDE Y; SYNAPSES;

EID: 1942472474     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705699     Document Type: Article

References (29)

1. BATTERHAM, R.L., COWLEY, M.A., SMALL, C.J., HERZOG, H., COHEN, M.A., DAKIN, C.L., WREN, A.M., BRYNES, A.E., LOW, M.J., GHATEI, M.A., CONE, R.D. & BLOOM, S.R. (2002). Gut hormone PYY(3-36) physiologically inhibits food intake. Nature, 418, 650-654.
2. BECK, B., BURLET, A., BAZIN, R., NICOLAS, J.P. & BURLET, C. (1993). Elevated neuropeptide Y in the arcuate nucleus of young obese Zucker rats may contribute to their overeating. J. Nutr., 123, 1168-1172.
3. BECK, B., BURLET, A., NICOLAS, J.P. & BURLET, C. (1990). Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats. J. Nutr., 120, 806-811.
4. BERGLUND, M.M., SCHOBER, D.A., STATNICK, M.A., MCDONALD, P.H. & GEHLERT, D.R. (2003). The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction. J. Pharmacol. Exp. Ther., 306, 147-156.
5. BLANTON, M.G., LO TURCO, J.J. & KRIEGSTEIN, A.R. (1989). Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex. J. Neurosci. Meth., 30, 203-210.
6. BRIEF, D.J., SIPOLS, A.J. & WOODS, S.C. (1992). Intraventricular neuropeptide Y injections stimulate food intake in lean but not obese Zucker rats. Physiol. Behav., 51, 1105-1110.
7. CABRELE, C., LANGER, M., BADER, R., WIELAND, H.A., DOODS, H.N., ZERBE, O. & BECK-SICKINGER, A.G. (2000). The first selective agonist for the neuropeptide Y Y5 receptor increases food intake in rats. J. Biol. Chem., 275, 36043-36048.
8. CLARK, J.T., KALRA, P.S., CROWLEY, W.R. & KALRA, S.P. (1984). Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology, 115, 427-429.
9. COWLEY, M.A., PRONCHUK, N., FAN, W., DINULESCU, D.M., COLMERS, W.F. & CONE, R.D. (1999). Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron, 24, 155-163.
10. CUSIN, I., ROHNER-JEANRENAUD, F., STRICKER-KRONGRAD, A. & JEANRENAUD, B. (1996). The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes, 45, 1446-1450.
11. DRYDEN, S., PICKAVANCE, L., FRANKISH, H.M. & WILLIAMS, G. (1995). Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats. Brain. Res., 690, 85-188.
12. ERICKSON, J.C., HOLLOPETER, G. & PALMITER, R.D. (1996). Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science, 274, 1704-1707.
13. KANATANI, A., ISHIHARA, A., ASAHI, S., TANAKA, T., OZAKI, S. & IHARA, M. (1996). Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake. Endocrinology, 137, 3177-3182.
14. LEVINE, A.S. & MORLEY, J.E. (1984). Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides, 5, 1025-1029.
15. MCCARTY, H.D., MCKIBBIN, P.E., HOLLOWAY, B., MAYERS, R. & WILLIAMS, G. (1991). Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats. Life Sci., 49, 1491-1497.
16. MCKIBBIN, P.E., COTTON, S.J., MCMILLAN, S., HOLLOWAY, B., MAYERS, R., MCCARTY, H.D. & WILLIAMS, G. (1991). Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbances. Diabetes, 40, 1423-1429.
17. MCQUISTON, A.R. & COLMERS, W.F. (1992). Neuropeptide Y does not alter NMDA conductances in CA3 pyramidal neurons: a slice-patch study. Neurosci. Lett., 138, 261-264.
18. MCQUISTON, A.R. & COLMERS, W.F. (1996). Neuropeptide Y inhibits the frequency of spontaneous, but not miniature, excitatory postsynaptic potentials in CA3 pyramidal cells of rat hippocampus. J. Neurophysiol., 76, 3159-3168.
19. PESONEN, U., HUPPONEN, R., ROURU, J. & KOULU, M. (1992). Hypothalamic neuropeptide expression after food restriction in Zucker rats: evidence of persistent neuropeptide Y gene activation. Brain Res. Mol. Brain Res., 16, 255-260.
20. PHILLIPS, M.S., LIU, Q., HAMMOND, H.A., DUGAN, V., HEY, P.J., CASKEY, C.T. & HESS, J.F. (1996). Leptin receptor missense mutation in the fatty Zucker rat. Nat. Genet., 13, 18-19.
21. PRONCHUK, N., BECK-SICKINGER, A.G. & COLMERS, W.F. (2002). Multiple NPY receptors inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus. Endocrinology, 143, 535-543.
22. RUDOLF, K., EBERLEIN, W., ENGEL, W., WIELAND, H.A., WILLIM, K.D., ENTZEROTH, M., WIENEN, W., BECK-SICKINGER, A.G. & DOODS, H.N. (1994). The first highly potent and selective nonpeptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur. J. Pharmacol., 271, R11-R13.
23. SAINSBURY, A., SCHWARTZER, C., COUZENS, M., FETISSIV, S., FURTINGER, S., JENKINS, A., COX, H.M., SPERK, G., HÖKFELT, T. & HERZOG, H. (2002). Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl. Acad. Sci. U.S.A., 99, 8938-8943.
24. SCHWARTZ, M.W., SEELY, R.I., CAMPFIELD, L.A., BURN, P. & BASKIN, D.G. (1996). Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest., 98, 1101-1106.
25. STANLEY, B. & LEIBOWITZ, S. (1985). Neuropeptide Y injected into the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. U.S.A., 82, 3940-3943.
26. STRICKER-KRONGRAD, A., KOZAK, R., BURLET, C., NICOLAS, J.P. & BECK, B. (1997). Physiological regulation of hypothalamic neuropeptide Y release in lean and obese rats. Am. J. Physiol., 273, R2112-R2116.
27. STRICKER-KRONGRAD, A., MAX, J.P., MUSSE, N., NICOLAS, J.P., BURLET, C. & BECK, B. (1994). Increased threshold concentration of neuropeptide Y for a stimulatory effect on food intake in obese Zucker rats-changes in the microstructure of the feeding behavior. Brain Res., 660, 162-166.
28. WANG, Q., BING, C., AL-BARAZANIJ, K., MOSSAKOWASKA, D.E., WANG, X.M., BAY, D.L., NEVILLE, W.A., TADDAYTON, M., PICKAVANCE, L., DRYDEN, S., THOMAS, M.E., MCHALE, M.T., GLOYER, I.S., WILSON, S., BUCKINGAM, R., ARCH, J.R., TRAYHURN, P. & WILLIAMS, G. (1997). Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes, 46, 335-341.
29. WIDDOWSON, P.S. (1997). Regionally selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to Y5 'feeding receptor'. Brain Res., 758, 17-25.