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Volumn 43, Issue 8, 2004, Pages 2611-2623

Adenosylcobinamide Plus Exogenous, Sterically Hindered, Putative Axial Bases: A Reinvestigation into the Cause of Record Levels of Co-C Heterolysis

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLIMIDAZOLE; 2,6 DIMETHYLPYRIDINE; ADENOSYLCOBINAMIDE; CARBON; COBALT; COBINAMIDE; DIMETHYLIMIDAZOLE; ETHYLENE GLYCOL; IMIDAZOLE DERIVATIVE; PICOLINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 1942467986     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic030141c     Document Type: Article
Times cited : (14)

References (101)
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    • A valuable aspect of the work from Marzilli's group23 and the present studies is that it draws attention to the rather common "insidious impurity problem": namely, that a trace impurity is causing problems in a reaction where one reagent is in large excess to the other reagents. Solvents are one common place where, for example, trace water or oxygen or other impurities can cause problems in reactions. Catalysis is a place where the substrate is in large excess vs the catalyst; the need to remove peroxides from olefins is a well know example.53 Autoxidations catalyzed by trace radical initiators or other reactions that can have large chain lengths are another example. Useful to note here are the general ways that one has to deal with this problem: (i) studies testing the reproducibility of a system using multiple batches of reagents from multiple suppliers, or different lots from the same supplier; (ii) studies using reagents purified by multiple methods; and (iii) studies examining a large change in the ratio of reagents with a careful examination of the resultant.23 Alternatively, (iv) the most powerful, but often most difficult, method of dealing with a trace impurity is to identify it directly, then either eliminate it, or alternatively to increase its concentration, that is, to decrease or increase its concentration and observe the effect.
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    • 2-py.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.