An Hypothesis Langerhans Cell Histiocytosis: The Failure of the Immune System to Switch from an Innate to an Adaptive Mode

Pediatric Blood and Cancer

Volumn 42, Issue 5, 2004, Pages 398-400

  Nezelof, Christian ^a   Basset, Françoise ^a  

^a NONE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTING CELL; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MOTILITY; DENDRITIC CELL; HISTIOCYTOSIS X; HODGKIN DISEASE; IMMUNE RESPONSE; IMMUNE SYSTEM; LANGERHANS CELL; LUNG ALVEOLUS CELL CARCINOMA; LYMPHOID CELL; LYMPHOMA; MACROPHAGE; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; REVIEW;

HISTIOCYTOSIS, LANGERHANS-CELL; HUMANS; IMMUNE SYSTEM; IMMUNITY, CELLULAR; LANGERHANS CELLS;

EID: 1942454731     PISSN: 15455009     EISSN: None     Source Type: Journal    
DOI: 10.1002/pbc.10463     Document Type: Review

References (17)

1. Favara BE. Perspective. Langerhans cell histiocytosis: An identity crisis. Med Pediatr Oncol 2001;37:545.
2. Zelger B. Langerhans cell histiocytosis: A reactive or neoplastic disorder? Med Pediatr Oncol 2001;37:543-547.
3. Betts DR, Leibundgut KE, Feldges A, et al. Cytogenetic abnormalities in Langerhans cell histiocytosis. Br J Cancer 1998; 77:552-555.
4. Murakami I, Gogusev J, Fournet JC, et al. Detection of molecular cytogenetic aberrations in Langerhans cell histiocytosis of bone. Hum Pathol 2002;33:555-560.
5. Willman CL, Busqul L, Griffith BB, et al. Langerhans cell histiocytosis (Histiocytosis X): A clonal proliferative disease. N Engl J Med 1994;331:154-160.
6. Nezelof C, Basset F. Langerhans cell histiocytosis research. Past, present, future. Hematol/Oncol Clin North Am 1998;12:385-406.
7. Delves PJ, Roitt IM. Advances in immunology: The immune system. New Engl J Med 2000;343:37-49.
8. Parkin J, Cohen B. An overview of the immune system. Lancet 2001;357:1777-1789.
9. Medzhitov R, Janeway C. Innate immunity. New Engl J Med 2000; 343:338-344.
10. Kimber I, Cumberbatch M, Derman RJ, et al. Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization. Br J Dermatol 2000;142:402-412.
11. Valladeau J, Ravel O, Dezutter-Dambuyant C, et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunology 2000;12:71-81.
12. Belardelli F, Ferrantini M. Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol 2002;23:201-208.
13. Egeler RM, Favara BE, van Meurs M, et al. Differential in situ profiles of Langerhans-like cells and T-cells in Langerhans cell histiocytosis: Abundant expression of cytokines relevant to disease and treatment. Blood 1999;94:4195-4201.
14. Egeler RM, Favara BE, Laman JD, et al. Abundant expression of CD40 and CD40-ligand (CD154) in paediatric Langerhans cell histiocytosis lesions. Eur J Cancer 2000;36:2105-2110.
15. Geissmann F, Lepelletier Y, Fraitag S, et al. Differentiation of Langerhans cells in Langerhans cell histiocytosis. Blood 2001;97: 1241-1248.
16. de Chadarévian JP, Pawel BR. Hereditary Langerhans cell histiocytosis: Instances of apparent vertical transmission. Med Pediatr Oncol 1998;31:559.
17. Favara BE, Jaffe R, Egeler RM. Macrophage activation and hemophagocytic syndrome in Langerhans cell histiocytosis. Pediatr Dev Pathol 2002;5:130-140.