Sexuality of the older woman;La sessualità nella donna anziana

Giornale di Gerontologia

Volumn 51, Issue 6, 2003, Pages 504-519

  Di Iusto, F ^a   Gambassi, Giovanni ^a   Mancini, A ^a   De Marinis, L ^a   Lauria Pantano, A ^a   Pedone, C ^a   Onder, G ^a   Bernabei, R ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Androgens; Estrogens; Menopause; Sexual dysfunction; Sexual response; Sildenafil

Indexed keywords

ANDROGEN; ANDROSTANOLONE; ANDROSTENEDIONE; ANTILIPEMIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; DANAZOL; DIGOXIN; ESTRADIOL; ESTROGEN; ESTROGEN DERIVATIVE; ESTRONE; ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS LEVONORGESTREL; GESTAGEN; LEVONORGESTREL; LITHIUM; NEUROLEPTIC AGENT; PHENYTOIN; PLACEBO; SEROTONIN UPTAKE INHIBITOR; SILDENAFIL; SPIRONOLACTONE; TESTOSTERONE; TIBOLONE; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG;

AGED; AGING; CLINICAL TRIAL; DRUG MECHANISM; DRUG METABOLISM; DYSPAREUNIA; ESTROGEN THERAPY; FEMALE; FEMALE SEXUAL DYSFUNCTION; GENDER; HORMONAL REGULATION; HUMAN; LIBIDO DISORDER; MENOPAUSE; ORGASM DISORDER; POSTMENOPAUSE; PREMENOPAUSE; REVIEW; SEXUAL AROUSAL; SEXUAL BEHAVIOR; SEXUALITY;

EID: 1942453787     PISSN: 00170305     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (92)

1. Carbonin P, Bernabei R, Zuccalà G, Gambassi G. Health care for older people. Country profile: Italy. J Am Geriatr Soc 1997;45:1519-22.
2. World Health Organization. Health aging: a discussion paper, WHO/NMH/HPS/01.1, 2002.
3. U.S. Bureau of the Census. Current population reports, special studies. 65+ in the United states. Washington, DC: government Printing Office (P23-190) 1996.
4. Manton KG, Gu XL. Changes in the prevalence of chronic disability in the United States black and nonblack population above age 65 from 1982 to 1999. Proc Nat Acad Sci USA 2001;98:6354-9.
5. Deck R, Kohlmann T, Jordan M. Health-related quality of life in old age: preliminary report on the male perspective. Aging Male 2002;5:87-97.
6. Yang H, Toy EC, Baker B. Sexual dysfunction in the elderly patient. Prim Care Update Ob Gyns 2000;7:269-74.
7. Janus SS, Janus CL. The Janus report on sexual behaviour. New York: John Wiley & Sons 1993.
8. Brecher EM. Love, sex and ageing. Comsumer's Union report. Boston, MA: Little, Brown 1984.
9. Leiblum SR, Bachmann GA. The sexuality of the climateric women. In: Eskin BA, ed. The menopause: comprehensive management. 3rd Edition. New York: Mc-Graw-Hill, Inc 1994:137.
10. Smith KE, Judd HL. Menopause and postmenopause. In: DeCherney AH, Pernoll ML, eds. Obstetrics and gynecologic diagnosis and treatment. East Norwalk, CT: Appleton and Lange 1994:1030.
11. Berkow R, Fletcher AJ. The Merck manual, 16th Ed. Rahway, NJ: Merck Research Laboratories 1992:2585.
12. Rannevik G, Jeppsson S, Johnell O, Bjerre B, Laurell-Borulf Y, Svanberg L. A longitudinal study of the perimenopausal transistion: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density. Maturitas 1995;21:103-13.
13. Lobo RA, Cassidenti DL. Pharmacokinetics of oral 17 beta-etradiol. J Reprod, Med 1992;37:77-84.
14. Vermeulen A. The hormonal activity of the postmenopausal ovary. J Clin Endocrinol Metab 1976;42:247-53.
15. Adaghi E. The climateric ovary as functional gonadotropin-driven androgen-producing gland. Fertil Steril 1994;62:20.
16. Judd H, Lucas W, Yen S. Effects of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer. Am J Obstet Gynecol 1974;118:793-8.
17. Orentreich N, Brind J, Rizer R, Vogelman J. Age changes and sex differences in serum dehydroepiandosterone sul fate concentrations throughout adulthood. J Clin Endocrinol Metab 1984;59:551-5.
18. Master WH, Johnson VE. Human sexual response. Boston, MA: Little, Brown 1966.
19. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th Edition. Washington, DC: American Psychiatric Association 1994:493.
20. Frank E, Anderson C, Rubinstein D. Frequency of sexual dysfunction in "normal" couples. N Engl J Med 1978;299:111-5.
21. Spector IP, Carey MP. Incidence and prevalence of the sexual dysfunction: A critical review of the empirical literature. Arch Sex Behav 1990;19:389-408.
22. Rosen RC, Taylor JF, Leiblum SR, Bachmann GA. Prevalence, of sexual dysfunction in women: results of a survey study of 329 women in an outpatient gynecological clinic. J Sex Marital Ther 1993;19:171-88.
23. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999;281:537-44.
24. Sarrel PM, Whitehead MI. Sex and monopause: defining the issues. Maturitas 1985;7:217-24.
25. Sarrel PM. Sexuality and menopause. Obstet Gynecol 1990;75:26s.
26. Schover LR, Friedman J, Weiler SJ, Heiman JR, LoPiccolo J. The multiaxial problem-oriented diagnostic system for the sexual dysfunction: an Alternative to DSM-III. Arch Gen Psychiatry 1982;39:614-9.
27. Sands R, Studd J. Exogenous androgens in postmenopausal women. Am J Med 1995;98:76S-79S.
28. Chakravarti S, Collins WP, Forecast JD, Newton JR, Oram DH, Studd JW. Hormonal profile after the menopause. BMJ 1976:784-7.
29. Labrie F, Luu-The V, Labrie C, Simard J. DHEA and its transformation into androgens and estrogen in peripheral target tissues: intracrinology. Front Neuroendocrinol 2001;22:185-212.
30. Phillips NA. The clinical evaluation of dyspareunia. Int J Impot Res 1998; 10:S117-20.
31. Butcher J. Female sexual problems II: sexual pain and sexual fears. BMJ 1999;318:41-3.
32. Phillips NA. Female sexual dysfunction.- evaluation and treatment. Am Fam Physician 2000;62:127-36,141-2.
33. Bachmann GA, Phillips NA. Sexual dysfunction. In: Steege JF, Metzger DA, Levy BS, eds. Chronic pelvic pain: an integrated approach. Philadelphia: Saunders 1998:77-90.
34. Shaw C. A systematic review of the literature on the prevalence of sexual impairment in women with urinary incontinence and the prevalence of urinary leakage during sexual activity. Eur Urol 2002;42:432-40.
35. Hilton P. Urinary incontinence during sexual intercourse: A common but rarely volunteered symptom. Br J Obstet Gynaecol 1988;95:377-81.
36. Kaiser FE. Sexual function and the older cancer patient. Oncology 1992;6:S112-8.
37. Schreiner-Engel P, Schiavi RC, Vietorisz D, Smith H. The differential impact of diabetes type on female sexuality. J Psychosom Rec 1987;31:23-33.
38. Barker MG. Psychiatric illness after hysterectomy. BMJ 1968;2:91-4.
39. Butcher J. Female sexual problems I: Loss of desire. What about the fun? BMJ 1999;318:41-3.
40. ACOG technical bulletin, Number 211. Sexual dysfunction. Int J Gynecol Obstet 1995;51:265.
41. Duncan LE, Lewis C, Jenkins P, Pearson TA. Does hypertension and its pharmacotherapy affect the quality of sexual function in women? Am J Hypertens 2000;13:640-7.
42. Clayton AH, Pradko JF, Croft HA, Montano CB, Leadbetter RA, Bolden-Watson C, et al. Prevalence of sexual dysfunction among newer antidepressants users. J Clin Psychiatry 2002;63:357-66.
43. Kaiser FE. Sexualty in the elderly. Urol Clin North Am 1996;23:99-109.
44. Bauer M. Sexuality and privacy for elderly living in nursing home. J Gerontol Nursing 1999;25:37-41.
45. Sarrel PM, Giblin K, Block BA. Sexual interest and functioning in postmenopausal women: a community-based national survey. Presented at the North American Menopause Society, September 1998, Toronto, Canada.
46. Kaplan HS. Injection treatment for older patients. In: Wagner G, Kaplan HS, eds. The new injection treatment for impotence. New York: Brunner, Mazel 1993:142.
47. The National Council on Aging Study. Healthy sexuality and Vital Aging. Washington, DC: 1998.
48. Onder G, Penninx BWJH, Guralnik JM, Jones H, Fried LP, Pahor M, et al. Sexual satisfaction and risk qf disability in older wowen. J Clin Psychiatry 2003;64:1177-82.
49. Modelska K, Cummings S. Female sexual dysfunction in postmenopausal women: systemic review of placebo-controlled trials. Am J Obstet Gynecol 2003;188:286-93.
50. Sarrel PM. Progestogens and blood flow. Int Proc J 1989;1:266.
51. Cutler WB, Garcia CR, McCoy N. Perimenopausal sexuality. Arch Sex Behav 1987;16:225-34.
52. Yee LA, Sundquist KJ. Older women's sexuality. MJA 2003;178:640-2.
53. Sarrel PM. Effects of hormone replacement therapy on sexual psychophysiology and behaviour in postmenopause. J Women's Health Gender-based Med 2000;9:S25-32.
54. Semmens JP, Wagner G. Estrogen deprivation and vaginal function in postmenopausal women. JAMA 1982;248:445-8.
55. Sarrel PM. Sexuality, and menopause. Obstet Gynecol 1990;75:26s-30s.
56. Utian WH. The true clinical features of postmenopause and oophorectomy and their response to oestrogen therapy. S Afr Med J 1972;46:732-6.
57. Coope J, Thomson JM, Poler L. Effects of "natural oestrogen" replacement therapy on menopausal symptoms and blood clotting. Br Med J 1975;4:139-43.
58. Sarrel PM, Giblin K, Liu X. Health care delivey and HRT experience: Effects of HRT continuance. Presented at the North American Menopause Society, September 1997, Boston, MA.
59. Dennerstein L, Burrows GD, Wood C, Hyman G. Hormones and sexuality. Effects of estrogen and progestogen. Obstet Gynecol 1980;51:316-22.
60. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985;47:339-51.
61. Sarrel PM, Giblin K, Liu X. Inadequacy of current HRT for sexual symptoms in 252 healthy postmenopausal women. North American Menopause Society, 1997; Boston, MA.
62. Tutten A, Laan E, Panhuysen G, Everaerd W, de Haan E, Koppeschaar H, et al. Discrepancies between genital responses and subjective sexual function during testosterone substitution in women with hypothalamic amenorrhea. Psychosom Med 1996;58:234-41.
63. Myers LS, Dixen J, Morrissette D, Carmichael M, Davidson JM. Effects of estrogen, androgen, and progestin on sexual psychophysiology and behaviour in postmenopausal women. J Clin Endocrinol Metab 1990;70:1124-31.
64. Davis SR, McCloud P, Strauss BJ, Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227-36.
65. Padero MC, Bhasin S, Friedman TC. Androgen Supplementation in Older Women: too much Hype, not enough data. J Am Geriatr Soc 2002;50:1131-40.
66. Artl W, Callies F, Allolio B. DHEA replacement in women with adrenal insufficiency-pharmacokinetics, bioconversion and clinical effects on well-being, sexuality and cognition. Endocr Res 2000;26:505-11.
67. Robel P, Baulieu E-E. Dehydroepiandrosterone is a neuroactive neurosteroid. Ann N Y Acad Sci 1995;774:82-110.
68. Robel P, Baulieu E-E. Neurosteroids: biosynthesis and function. Crit Rev Neurobiol 1995;9:383-94.
69. Greenblatt RB, Barfield WE, Garner JF. Evaluation of an estrogen, androgen, and estrogen-androgen combination, and a placebo in the treatment of the menopause. J Clin Endocrinol Metab 1950;10:1547-52.
70. Birnberg CH, Kurzork R. Low dosage androgen-estrogen therapy in the older age group. J Am Geriatr Soc 1955;3:656-60.
71. Kupperman HS, Wetchler BB, Blatt MHG. Contemporary therapy of the menopausal syndrome. JAMA 1959;171:1627-31.
72. Cardozo, Gibb DM, Tuck SM, Thom MH, Studd JW, Cooper DJ. The effects of subcutaneous hormone implants during climacteric. Maturitas 1984;5:177-84.
73. Burger HG, Hailes J, Menelaus M, Nelson J, Hudson B, Balazs N. The management of persistent menopausal symptoms with oestradiol-testosterone implants: clinical, lipid and hormonal result. Maturitas 1984;6:351-8.
74. Sherwin BB. Changes in sexual behavior as a function of plasma sex steroid levels in post-menopausal women. Maturitas 1985;7:225-33.
75. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987;49:397-409.
76. Davis SR, Burger HG. Androgens and the postmenopausal woman. J Clin Endocrinol Metab 1996;81:2759-63.
77. Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postemenopausal women dissatisfied with estrogen-only therapy: sexual behavior and neuroendocrine responses. J Reprod Med 1998;43:847-56.
78. Shifren JL, Braunstein GD, Simon JA, Casson PR, Buster JE, Redmond GP. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343:682-8.
79. Kloosterboer HJ. Tibolone: a steroid with tissue-specific mode of action. Steroid Biochem Mol Biol 2001;76:231-8.
80. Nevinny-Stickel J. Double-blind cross-over study with Org OD 14 and placebo in postmenopausal patients. Arch Gynecol 1983;234:27-31.
81. Laan E, van Lunsen RH, Everaerd W. The effects tibolone on vaginal blood flow, sexual desire and arousability in postmenopausal women. Climacteric 2001;4:28-41.
82. Nathorst-Boos J, Hammar M. Effect on sexual life - a comparison between tibolone and a continuous estradiol-norethisterone acetate regimen. Maturitas 1997;26:15-20.
83. Doren M, Rubig A, Coelingh Bennink HJ, Holzgreve W. Differential effects on the androgen status of postmenopausal women treated with tibolone and continuous combined estradiol and norethindrone acetate replacement therapy. Fertil Steril 2001;75:554-9.
84. Wu MH, Pan HA, Wang ST, Hsu CC, Chang FM, Huang KE. Quality of life and sexuality changes in postmenopausal women receiving tibolone therapy. Climacteric 2001;4:314-9.
85. Schiavi RC, Segraves RT. The biology of sexual function. Psychiatr Clin North Am 1995;18:7-23.
86. D'Amati G, Lenzi A, Tannini EA. Functional anatomy of the human vagina. J Endocrinol Invest 2003;26:S92-6.
87. Park K, Moreland RB, Goldstein I, Atala A, Traish A. Characterization of phosphodiesterase activity in human clitoral corpus cavernosum smooth muscle cells in culture. Biochem Biophys Res Commun 1998;249:612-7.
88. Kaplan SA, Reis RB, Kohn IJ, Ikeguchi EF, Laor E, Te AE, et al. Safety ad efficacy of sildenafil in postmenopausal women with sexual dysfunction. Urology 1999;53:481-6.
89. Nurnberg HG, Hensley PL, Lauriello J, Parker LM, Keith SJ. Sildenafil for women with antidepressant-induced sexual dysfunction. Psychiatric Serv 1999;50:1076-8.
90. Sipski MA, Rosen RC, Alexander CJ, Hamer RM. Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury. Urology 2000;55:812-5.
91. Basson R, McInnes R, Smith MD, Hodgson G, Spain T, Koppiker N. Efficacy and safety of sildenafil in estrogenized women with sexual dysfunction associated with female sexual arousal disorder. Obstet Gynecol 2000;95:51-4.
92. Lazaer M, Daini S, Mancini A, De Marinis L. La sessualità nella donna in menopausa: aspetti personali e di coppia. J Sexol Sci 1995;8:35-8.