Peak capacity of ion mobility mass spectrometry: The utility of varying drifts gas polarizability for the separation of tryptic peptides

Journal of Mass Spectrometry

Volumn 39, Issue 4, 2004, Pages 361-367

  Ruotolo, Brandon T ^a   McLean, John A ^a   Gillig, Kent J ^a   Russell, David H ^a  

^a Texas AandM University   (United States)

Author keywords

Conformation; Matrix assisted laser desorption ionization; Peptides; Proteomics; Separation

Indexed keywords

ENZYMES; IONS; LIGHT POLARIZATION; LIGHT SCATTERING; LIGHT TRANSMISSION; MUSCLE;

CONFORMERS; DRIFT GAS; PEAK CAPACITY; TRANSMISSION LOSSES;

MASS SPECTROMETRY;

ARGON; BETA CASEIN; CARBONATE DEHYDRATASE; FRUCTOSE BISPHOSPHATE ALDOLASE; HELIUM; HEMOGLOBIN; LUCIFERASE; LYSOZYME; METHANE; MYOGLOBIN; NITROGEN; OVALBUMIN; PEPTIDE DERIVATIVE; PHOSPHORYLASE; RIBONUCLEASE A; SERUM ALBUMIN; TRANSFERRIN; TRYPSIN; UBIQUITIN;

ARTICLE; CONTROLLED STUDY; INTERMETHOD COMPARISON; ION MOBILITY SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PHASE SEPARATION; POLARIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PURIFICATION; RABBIT; SIGNAL TRANSDUCTION; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; FRUCTOSE-BISPHOSPHATE ALDOLASE; GASES; KINETICS; MASS SPECTROMETRY; PEPTIDE FRAGMENTS; RABBITS; TRYPSIN;

ORYCTOLAGUS CUNICULUS;

EID: 1942420732     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.592     Document Type: Article

References (39)

1. Cheng X, Hochlowski J. Current application of mass spectrometry to combinatorial chemistry. Anal. Chem. 2002; 74: 2679.
2. Aebersold R, Goodlett DR. Mass spectrometry in proteomics. Chem Rev. 2001; 101: 269.
3. Kelleher NL. From primary structure to function: biological insights from large-molecule mass spectra. Chem. Biol. 2000; 7: R37.
4. Burlingame AL, Carr SA, Baldwin MA (eds). Mass Spectrometry in Biology and Medicine. Humana Press: Totowa, NJ, 2000; 577.
5. MacCoss MJ, Wu CC, Yates JR. Probability-based validation of protein identifications using a modified SEQUEST algorithm. Anal. Chem. 2002; 74: 5593.
6. Jensen ON, Podtelejnikov AV, Mann M. Identification of the components of simple protein mixtures by high-accuracy peptide mass mapping and database searching. Anal. Chem. 1997; 69: 4741.
7. Griffin PR, Coffman JA, Hood LE, Yates JR. Structural analysis of proteins by capillary HPLC-electrospray tandem mass spectrometry. Int. J. Mass Spectrom. Ion Processes 1991; 111: 131.
8. Peng J, Gygi SP. Proteomics: the move to mixtures. J. Mass Spectrom. 2001; 36: 1083.
9. Champion MM, Campbell CS, Siegele DA, Russell DH, Hu JC. Proteome analysis of Escherichia coli K-12 by two-dimensional native-state chromatography and MALDI-MS. Mol. Microbiol. 2003; 47: 383.
10. Wolters DA, Washburn MP, Yates JR. An automated multidimensional protein identification technology for shotgun proteomics. Anal. Chem. 2001; 73: 5683.
11. Holland JF, Enke CG, Allison J, Stults JT, Pinkston JD, Newcome B, Watson JT. Mass spectrometry on the chromatographic time scale: realistic expectations. Anal. Chem. 1983; 55: 997A.
12. Von Helden G, Wyttenbach T, Bowers MT. Conformation of macromolecules in the gas phase: use of matrix-assisted laser desorption methods in ion chromatography. Science 1995; 267: 1483.
13. Jarrold MF. Peptides and proteins in the vapor phase. Annu. Rev. Phys. Chem. 2000; 51: 179.
14. Hoaglund-Hyzer CS, Counterman AE, Clemmer DE. Anhydrous protein ions. Chem. Rev. 1999; 99: 3037.
15. Valentine SJ, Counterman AE, Hoaglund CS, Reilly JP, Clemmer DE. Gas-phase separations of protease digests. J. Am. Soc. Mass Spectrom. 1998; 9: 1213.
16. Ruotolo BT, Gillig KJ, Stone EG, Russell DH, Fuhrer K, Gonin M, Schultz JA. Analysis of protein mixtures by matrix-assisted laser desorption ionization-ion mobility-orthogonal time-of-flight mass spectrometry. Int. J. Mass Spectrom. 2002; 219: 253.
17. Ruotolo BT, Verbeck GF, Thomson LM, Woods AS, Gillig KJ, Russell DH. Distinguishing between phosphorylated and nonphosphorylated peptides with ion mobility-mass spectrometry. J. Proteome Res. 2002; 1: 303.
18. Stone EG, Gillig KJ, Ruotolo B, Fuhrer K, Gonin M, Schultz A, Russell DH. Surface-induced dissociation on a MALDI-ion mobility-orthogonal time-of-flight mass spectrometer: sequencing peptides from an 'in-solution' protein digest. Anal. Chem. 2001; 73: 2233.
19. Stone EG, Gillig KJ, Ruotolo BT, Russell DH. Optimization of a matrix-assisted laser desorption ionization-ion mobility-surface-induced dissociation-orthogonal time-of-flight mass spectrometer: simultaneous acquisition of multiple correlated MS1 and MS2 spectra. Int. J. Mass Spectrom. 2001; 212: 519.
20. Fuhrer K, Gonin M, McCully MI, Egan T, Ulrich SR, Vaughn VW, Burton WD, Schultz JA, Gillig K, Russell DH. Monitoring of fast processes by TOFMS. In Proceedings of the 49th ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, IL, 2001.
21. Ruotolo BT, Gillig KJ, Stone EG, Russell DH. Peak capacity of ion mobility mass spectrometry: separation of peptides in helium buffer gas. J. Chromatogr. B 2002; 782: 385.
22. Asbury GR, Hill HH. Using different drift gases to change separation factors (α) in ion mobility spectrometry. Anal. Chem. 2000; 72: 580.
23. Matz LM, Hill HH, Beegle LW, Kanik I. Investigation of drift gas selectivity in high resolution ion mobility spectrometry with mass spectrometry detection. J. Am. Soc. Mass Spectrom. 2002; 13: 300.
24. Beegle LW, Kanik I, Matz L, Hill HH. Effects of drift-gas polarizability on glycine peptides in ion mobility spectrometry. Int. J. Mass Spectrom. 2002; 216: 257.
25. Hill HH, Hill CH, Asbury GR, Wu C, Matz LM, Ichiye T. Charge location on gas phase peptides. Int. J. Mass Spectrom. 2002; 219: 23.
26. Mason EA, McDaniel EW. The Mobility and Diffusion of Ions in Gases. Wiley: New York, 1973; 384.
27. Mason EA. In Plasma Chromatography, Carr TW (ed). Plenum Press: New York, 1984; 43.
28. Boehringer H, Fahey DW, Lindinger W, Howorka F, Fehsenfeld FC, Albritton DL. Mobilities of several mass-identified positive and negative ions in air. Int. J. Mass Spectrom. Ion Processes 1987; 81: 45.
29. Tammet H. Size and mobility of nanometer particles, clusters and ions. J. Aerosol Sci. 1995; 26: 459.
30. Mesleh MF, Hunter JM, Shvartsburg AA, Schatz GC, Jarrold MF. Structural information from ion mobility measurements: effects of the long-range potential. J. Phys. Chem. 1996; 100: 16 082.
31. Kohtani M, Jarrold MF. The initial steps in the hydration of unsolvated peptides: water molecule adsorption on alanine-based helices and globules. J. Am. Chem. Soc. 2002; 124: 11148.
32. Gillig KJ, Ruotolo BT, Stone EG, Russell DH. Periodic field focusing ion mobility spectrometer/mass spectrometer. Rev. Sci. Instrum. submitted.
33. Park ZY, Russell DH. Thermal denaturation: a useful technique in peptide mass mapping. Anal. Chem. 2000; 72: 2667.
34. Giddings JC. Two-dimensional separations: concept and promise. Anal. Chem. 1984; 56: 1258A.
35. Karger BL, Snyder LR, Horvath C. An Introduction to Separation Science. Wiley- Interscience: New York, 1973; 624.
36. Valentine SJ, Counterman AE, Hoaglund-Hyzer CS, Clemmer DE. Intrinsic amino acid size parameters from a series of 113 lysine-terminated tryptic digest peptide ions. J. Phys. Chem. B 1999; 103: 1203.
37. Ruotolo BT, Verbeck GF, Thomson LM, Gillig KJ, Russell DH. Observation of conserved solution-phase secondary structure in gas-phase tryptic peptides. J. Am. Chem. Soc. 2002; 124: 4214.
38. McLean JA, Ruotolo BT, Gilllig KJ, Russell DH. Enhanced protein coverage in peptide mass mapping with MALDI-ion mobility-TOF MS using alternate drift gases. J. Proteome Res. in preparation.
39. Böttcher CJF, Bordewijk P. Theory of Electric Polarization, (2nd edn), vol. 2. Elsevier: New York, 1978; 561.