Differential inhibition of rat α3* and α7 nicotinic acetylcholine receptors by tetrandrine and closely related bis- benzylisoquinoline derivatives

Neuroscience Letters

Volumn 381, Issue 3, 2005, Pages 299-304

  Virginio, Caterina ^a   Graziani, Francesca ^a   Terstappen, Georg C ^b  

^a GSK   (Italy)

^b Siena Biotech SpA   (Italy)

Author keywords

7 subunit; Berbamine; GH4C1 cells; Hernandezine; MLA; Nicotinic acetylcholine receptor; Patch clamp; PC12 cells; Tetrandrine

Indexed keywords

BENZYLISOQUINOLINE DERIVATIVE; BERBAMINE; HERNANDESINE; METHYLLYCACONITINE; NICOTINIC RECEPTOR; TETRANDRINE;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; IC 50; ISOTOPE LABELING; NERVE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALKALOIDS; ANIMALS; BENZYLISOQUINOLINES; BINDING, COMPETITIVE; CALCIUM CHANNEL BLOCKERS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, NICOTINIC;

EID: 19344375316     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.02.035     Document Type: Article

References (17)

1. B.M. Conti-Fine, D. Navaneetham, S. Lei, and A.D.J. Maus Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity? Eur. J. Pharmacol. 393 2000 279 294
2. N.D. Cook Scintillation proximity assay: a versatile high-throughput screening technology Drug Discov. Today 1 1996 287 294
3. C.J. Herrero, E. García-Palomero, A.J. Pintado, A.G. García, and C. Montiel Differential blockade of rat α3β4 and α7 neuronal nicotinic receptors by ω-conotoxin MVIIC, ω-conotoxin GVIA and diltiazem Br. J. Pharmacol. 127 1999 1375 1387
4. 6 and calmodulin-dependent myosin light chain kinase Biochem. Pharmacol. 44 1992 1543 1547
5. 2+ channels in vascular endothelial cells Life Sci. 68 2001 841 847
6. 2+ in human leukaemic HL-60 cells: a structure-activity relationship study Clin. Exp. Pharmacol. Physiol. 23 1996 653 659
7. W.B. Liu, G.Q. Liu, H. Xiao, X. Mao, Y. Shi, and J.P. Wu Tetrandrine inhibits inward rectifying potassium current in cultured bovine aortic endothelial cells Acta Pharmacol. Sin. 21 2000 1115 1118
8. H. Matsubayashi, M. Alkondon, E.F.R. Pereira, K.L. Swanson, and E.X. Albuquerque Strychnine: a potent competitive antagonist of α-bungarotoxin- sensitive nicotinic acetylcholine receptors in rat hippocampal neurons J. Pharmacol. Exp. Ther. 284 1998 904 913
9. M. Oyaizu, and T. Narahashi Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nootropic drug nefiracetam Brain Res. 822 1999 72 79
10. C.B. Ransom, and H. Sontheimer BK channels in human glioma cells J. Neurophysiol. 85 2001 790 803
11. Y. Slater, L.M. Houlihan, B.K. Cassels, R.J. Lukas, and I. Bermúdez Effects of the plant alkaloid tetrandrine on human nicotinic acetylcholine receptors Eur. J. Pharmacol. 450 2002 213 221
12. G.C. Terstappen, A. Pellacani, A. Aldegheri, F. Graziani, C. Carignani, G. Pula, and C. Virginio The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3 Neurosci. Lett. 346 2003 85 88
13. C. Virginio, F. Graziani, and G.C. Terstappen Pharmacological properties of rat α7 nicotinic receptors expressed in native and recombinant cell systems Eur. J. Pharmacol. 445 2002 153 161
14. + channels Life Sci. 56 1995 295 306
15. G. Wang, J.R. Lemos, and C. Iadecola Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation TIPS 25 2004 120 123
16. S. Weiland, D. Bertrand, and S. Leonard Neuronal nicotinic acetylcholine receptors: from the gene to the disease Behav. Brain Res. 113 2000 43 56
17. 2+ increase induced by glutamate, serotonin and histamine in dissociated retina cells J. Ocul. Pharmacol. Ther. 12 1996 331 336