Specific inhibitors of inducible nitric oxide synthase: Efficacy in a rodent model of sepsis

Inflammation Research

Volumn 48, Issue SUPPL. 2, 1999, Pages

  Fretland, D J ^a   Widomski, D L ^a   Anglin, C P ^a   Moore, W ^b   Jerome, G ^b   Kornmeier, C ^b   Connor, J ^b   Branson, L ^b   Wyatt, P ^b   Manning, P ^b   Toth, M ^b   Webber, R K ^b   Hansen, D ^a   Hallinan, E A ^a   Hagen, T ^a   Bergmanis, A ^a   Pitzele, B ^a   Currie, M G ^b  

^a PFIZER INC   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; LETHALITY; NONHUMAN; RAT; SEPSIS;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; LIPOPOLYSACCHARIDES; MICE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 19244374890     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (6)

1. Lyons C. The role of nitric oxide in inflammation. Adv Immunol 1995; 60: 323-71.
2. Fretland D, Connor JR, Pitzele BS, Currie MG, Manning PT. Inhibition of nitric oxide synthase and prospects for therapy in inflammatory diseases. Curr Pharmaceutical Design 1997; 3: 447-62.
3. Tracey WR, Tse J, Carter GW. LPS-induccd changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacologial evaluation of nitric oxide synthase inhibitors. J Pharmacol Exp Ther 1995; 272: 1011-5.
4. Fretland DJ, Anglin CP, Widomski DL, Connor JR. Wyatt P, Manning PT, et al. Temporal relationships of cytokine production in mouse non-lethal sepsis: effect of nitric oxide synthase inhibitors. Inflamm Res 1997; 46: S21-2.
5. Hagen TJ, Bergmanis AA, Kramer SW, Kok K, Schmelzer AE, Pitzele BS, et al. 2-Iminopyrrolidines as potent selective inhibitors of 8 human inducible nitric oxide synthase. J Med Chem 1998; 41: 3675-86.
6. Evans T, Carpenter A, Silva A, Vonderwank S, Cohen J. Inhibition of nitric oxide in experimental gram negative sepsis. J Infect Dis 1994; 169: 343-50.