Molecular determinants of UV-induced immunosuppression

Experimental Dermatology, Supplement

Volumn 11, Issue 1, 2002, Pages 9-12

  Schwarz, Agatha ^a   Schwarz, Thomas ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Contact hypersensitivity; DNA damage; Immunosuppression; Interleukin; Ultraviolet radiation

Indexed keywords

DNA; INTERLEUKIN 10; INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; RADIATION EXPOSURE; SKIN; SKIN CANCER; T LYMPHOCYTE; ULTRAVIOLET RADIATION; ANIMAL; DRUG EFFECT; HUMAN; IMMUNOLOGICAL TOLERANCE; REVIEW;

ANIMALS; DNA; DNA DAMAGE; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-12; ULTRAVIOLET RAYS;

EID: 19044393915     PISSN: 14791250     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.11.s.1.3.x     Document Type: Article

References (27)

1. Toews G B, Bergstresser P R, Streilein J W. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 1980: 124: 445-453.
2. Elmets C A, Bergstresser P R, Tigelaar R E, Wood P J, Streilein J W. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med 1983: 158: 781-794.
3. Schwarz T. Ultraviolet radiation-induced tolerance. Allergy 1999: 54: 1252-1261.
4. Shreedar V K, Pride M W, Sun Y, Kripke M L, Strickland F M. Origin and characteristics of ultraviolet-B radiation-induced suppressor T lymphocytes. J Immunol 1998: 161: 1327-1335.
5. Schwarz A, Beissert S, Grosse-Heitmeyer K et al. Evidence for functional relevance of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in UV-induced tolerance. J Immunol 2000: 165: 1824-1831.
6. Moodycliffe A M, Nghiem D, Clydesdale G, Ullrich S E. Immune suppression and skin cancer development: regulation by NKT cells. Nat Immunol 2000: 1: 521-525.
7. Noonan F P, DeFabo E C, Kripke M L. Suppression of contact hypersensitivity by UV radiation and its relationship to UV-induced suppression of tumor immunity. Photochem Photobiol 1981: 34: 683-689.
8. Schwarz T, Urbanska A, Gschnait F, Luger T A. Inhibition of the induction of contact hypersensitivity by a UV-mediated epidermal cytokine. J Invest Dermatol 1986: 87: 289-291.
9. Rivas J M, Ullrich S E. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J Immunol 1992: 149: 3865-3871.
10. Trinchieri G. Interleukin-12 and its role in the generation of Th1 cells. Immunol Today 1993: 14: 335-338.
11. Müller G, Saloga J, Germann T, Schuler G, Knop J, Enk A H. IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo. J Immunol 1995: 155: 4661-4668.
12. Schmitt D A, Owen-Schaub L, Ullrich S E. Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J Immunol 1995: 154: 5114-5120.
13. Schwarz A, Grabbe S, Aragane Y et al. Interleukin-12 prevents UVB-induced local immunosuppression and overcomes UVB-induced tolerance. J Invest Dermatol 1996: 106: 1187-1191.
14. DeFabo E C, Noonan F P. Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med 1983: 158: 84-98.
15. Norval M. Chromophore for UV-induced immunosuppression: urocanic acid. Photochem Photobiol 1996: 63: 386-390.
16. Beissert S, Rühlemann D, Mohammad T et al. Interleukin-12 prevents the inhibitory effects of cis-urocanic acid on tumor antigen presentation by Langerhans cells: implications for photocarcinogenesis. J Immunol 2001: 167: 6232-6238.
17. Aragane Y, Kulms D, Luger T A, Schwarz T. Downregulation of interferon-γ-activated STAT1 by ultraviolet light. Proc Natl Acad Sci USA 1997: 94: 11490-11495.
18. Kulms D, Schwarz T. Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STATS in T lymphocytes. J Biol Chem 2001: 276: 12849-12855.
19. de Laat W L, Jaspers N G, Hoeijmakers J. Molecular mechanism of nucleotide excision repair. Genes Dev 1999: 13: 768-785.
20. Yarosh D, Bucana C, Cox P, Alas L, Kibitel J, Kripke M L. Localization of liposomes containing a DNA repair enzyme in murine skin. J Invest Dermatol 1994: 103: 461-468.
21. Kripke M L, Cox P A, Alas L G, Yarosh D B. Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice. Proc Natl Acad Sci USA 1992: 89: 7516-7520.
22. Applegate L A, Ley R D, Alcalay J, Kripke M L. Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation. J Exp Med 1989: 170: 1117-1131.
23. Nishigori C, Yarosh D B, Ullrich S E et al. Evidence that DNA damage triggers interleukin 10 cytokine production in UV irradiated murine keratinocytes. Proc Natl Acad Sci USA 1996: 93: 10354-10359.
24. Kibitel J, Hejmadi V, Alas L, O'Connor A, Sutherland B M, Yarosh D. UV-DNA damage in mouse and human cells induces the expression of tumor necrosis factor a. Photochem Photobiol 1998: 67: 541-546.
25. Schmitt D A, Walterscheid J P, Ullrich S E. Reversal of ultraviolet radiation-induced immune suppression by recombinant interleukin-12: suppression of cytokine production. Immunology 2000: 101: 90-96.
26. Schwarz A, Ständer S, Berneburg M et al. Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol 2002: 4: 26-31.
27. Kulms D, Pöppelmann B, Yarosh D, Luger T A, Krutmann J, Schwarz T. Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to ultraviolet B radiation. Proc Natl Acad Sci USA 1999: 96: 7974-7979.