Characterization and regulation of new secondary metabolites from Aspergillus ochraceus M18 obtained by UV mutagenesis

Canadian Journal of Microbiology

Volumn 51, Issue 1, 2005, Pages 59-67

  Awad, Gamal ^a   Mathieu, Florence ^a   Coppel, Yannick ^a   Lebrihi, Ahmed ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Aspergillus ochraceus; Mycotoxins; Ochratoxin; Penicillic acid; Regulation; Secondary metabolites

Indexed keywords

ANTIBIOTICS; BACTERIA; BIODIVERSITY; BIOSYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IRRADIATION; MUTAGENESIS; ULTRAVIOLET RADIATION;

ANTIBIOTIC ACTIVITY; MUTANTS; UV IRRADIATION;

METABOLITES;

2,10 DIMETHYL 4 HYDROXY 6 OXO 4 UNDECEN 7 YNE; 4 (3 METHYL 2 BUTENYL)OXY 1 PHENYLACETIC ACID; ALKYNE DERIVATIVE; CARBON; MYCOTOXIN; NITROGEN; OCHRATOXIN; PENICILLIC ACID; PHENYLACETIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

FUNGUS; SECONDARY METABOLITE; TOXIN;

ARTICLE; ASPERGILLUS OCHRACEUS; BACILLUS SUBTILIS; BACTERIAL GROWTH; BIOSYNTHESIS; CARBON SOURCE; ENERGY RESOURCE; FUNGUS GROWTH; FUNGUS MUTATION; GRAM NEGATIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET RADIATION;

ANTI-BACTERIAL AGENTS; ASPERGILLUS OCHRACEUS; CARBON; CULTURE MEDIA; FATTY ALCOHOLS; GENE EXPRESSION REGULATION, FUNGAL; GRAM-POSITIVE BACTERIA; KETONES; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS; MYCOTOXINS; NITROGEN; OCHRATOXINS; PHENYLACETATES; ULTRAVIOLET RAYS;

ASPERGILLUS OCHRACEUS; BACILLUS SUBTILIS; FUNGI; NEGIBACTERIA; OXY; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 19044377255     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/w04-117     Document Type: Article

References (38)

1. Aharonowitz, Y., and Demain, A.L. 1978. Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 14: 159-164.
2. Aziz, N.H., and Smyk, B. 2002. Influence of UV radiation and nitrosamines on the induction of mycotoxins synthesis by nontoxigenic moulds isolated from feed samples. Nahrung-Food, 46: 118-121.
3. Bode, H.B., Bethe, B., Höfs, R., and Zeeck, A. 2002. Big effects from small changes: possible ways to explore nature's chemical diversity. Chem. Biochem. 3: 619-627.
4. Demain, A.L. 1991. Production of beta-lactam antibiotics and its regulation. Proc. Natl. Sci. Counc. Repub. China Part B Life Sci. 15: 251-265.
5. Fraleigh, S., Bungay, H., and Rechter, A. 1989. Minireview-regulation of oxidoreductive yeast metabolism by extracellular factors. J. Biotechnol. 12: 185-198.
6. Gallo, M., and Katz, E. 1972. Regulation of secondary metabolite biosynthesis: Catabolite repression of phenoxazinone synthase and actinomycin formation by glucose. J. Bacteriol. 109: 659-667.
7. Giordano, W., Avalos, J., Cerdao, E., and Domenech, C.E. 1999. Nitrogen availability and production of bikaverin and gibberellins in Gibberella fujikuroi. FEMS Microbiol. Lett. 173: 389-393.
8. Hadidane, R., Bacha, H., Creppy, E.E., Hammami, M., Ellouze, F., and Dirheimer, G. 1992. Isolation and structure determination of natural analogues of the mycotoxin ochratoxin A produced by Aspergillus ochraceus. Toxicology, 76: 233-243.
9. Hao, X., Ronald, R., David, A., and Avdrew, A. 1996. Metabolites of ochratoxins in rat urine and in a culture of Aspergillus ochraceus. Appl. Environ. Microbiol. 62: 648-655.
10. Harris, J.P., and Mantle, P.G. 2001. Biosynthesis of diaportin and orthosporin by Aspergillus ochraceus. Phytochemistry, 57: 165-169.
11. Hurley, L.H., and Bialek, D. 1974. Regulation of antibiotic production: Catabolite inhibition and the dualistic effect of glucose on indolmycin production. J. Antibiot. 27: 49-56.
12. Içgen, Y., Içgen, B., and Özcengiz, G. 2002. Regulation of crystal protein biosynthesis by Bacillus thuringiensis: II. Effects of carbon and nitrogen sources. Res. Microbiol. 153: 603-609.
13. Jayant, N., and Suresh, R. 1999. Moderate protective effect of 6-MFA, a microbial metabolite obtained from Aspergillus ochraceus on immunological liver injury in mice. Comp. Immunol. Microbiol. Infect. Dis. 22: 15-25.
14. Jonathan, P.H., and Peter, G.M. 2001a. Biosynthesis of ochratoxins by Aspergillus ochraceus. Phytochemistry, 58: 709-716.
15. Jonathan, P.H., and Peter, G.M. 2001b. Biosynthesis of diaporthin and orthosporin by Aspergillus ochraceus. Phytochemistry, 57: 165-169.
16. Kanno, H., and Taylor, R. 2002. Tandem oxidation processes: the direct conversion of activated alcohols to oximes; synthesis of citaldoxime. Synlett, 8: 1287-1290.
17. Kennedy, J., and Hutchinson, C.R. 1999. Nurturing nature: engineering new antibiotics. Nat. Biotechnol. 17: 538-539.
18. Lai, L.T., Pan, C.C., and Tzeng, B.K. 2003. The influence of medium design on lovastatin production and pellet formation with a high-producing mutant of Aspergillus terreus in submerged cultures. Process Biochem. 38: 1317-1326.
19. Lebrihi, A., Germain, P., and Lefebvre, G. 1987. Phosphate repression of cephamycin and clavulanic acid production by Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 26: 130-135.
20. Lebrihi, A., Lefebvre, G., and Germain, P. 1988. Carbon catabolite regulation of cephamycin C and expandase biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 28: 44-51.
21. Lebrihi, A., Lamsaif, D., Lefebvre, G., and Germain, P. 1992. Effect of ammonium ions on spiramycin biosynthesis in Streptomyces ambofaciens. Appl. Microbiol. Biotechnol. 37: 382-387.
22. Lee, S.H. 1997. Ammonium ion affecting tylosin production by Streptomyces fradiae NRRL 2702 in continuous culture. Lett. Appl. Microbiol. 25: 349-352.
23. Litzka, O., Then Bergh, K., Van den Brulle, J., Steidl, S., and Brakhage, A.A. 1999. Transcriptional control of expression of fungal beta-lactam biosynthesis genes. Antonie Leeuwenhoek, 75: 95-105.
24. Lopez, C.J.L., Perez, S.J.A., Sevilla, F.J.M., Fernandez, A.F.G., Grima, M.E., and Chisti, Y. 2003. Production of lovastatin by Aspergillus terreus: Effects of the C:N ratio and the principal nutrients on growth and metabolite production. Enzyme Microb. Technol. 23: 270-277.
25. Lounes, A., Lebrihi, A., Benslimane, C., Lefebvre, G., and Germain, P. 1995. Regulation of valine catabolisme by ammonium in Streptomyces ambofaciens, producer of spiramycin. Can. J. Microbiol. 41: 800-808.
26. Marquardt, R.R., and Frohlich, A.A. 1992. A review of recent advances in understanding ochratoxicosis. J. Anim. Sci. 70: 3968-3988.
27. Martin, J.F., and Demain, A.L. 1980. Control of antibiotic biosynthesis. Microbiol. Rev. 44: 230-251.
28. Martin, J.F., Casqueiro, J., Kosalkova, K., Marcos, A.T., and Gutiérrez, A. 1999. Penicillin and cephalosporin biosynthesis: Mechanism of carbon catabolite regulation of penicillin production. Antonie Leeuwenhoeck, 75: 21-31.
29. Mitsudo, T., Nakagawa, Y., Watanabe, K., Hori, Y., Misawa, H., Watanabe, H., and Watanabe, Y. 1985. The first selectve linear codimerization of terminal acetylenes and 1,3-dienes catalyzed by dihydridotetrakis (trialkylphosphine) ruthenium complexes. J. Org. Chem. 50: 565-571.
30. Moore, B.S., Walker, K., Tornus, I., Handa, S., Poralla, K., and Floss, H.G. 1997. Biosynthetic studies of ω-cycloheptyl fatty acids in Alicyclobacillus cycloheptanicus. Formation of cycloheptanecarboxylic acid from phenylacetic acid. J. Org. Chem. 62: 2173-2185.
31. Omura, S., Tanaka, Y., Tanaka, H., Takahashi, Y., and Iwai, Y. 1980. Stimulation of the production of macrolide antibiotics by magnesium phosphate and related insoluble materials. J. Antibiot. 33: 1568-1569.
32. Parisi, A., Piattelli, M., Tringali, C., and Magnano, G. 1993. Identification of the phytotoxin mellein in culture fluids of Phoma tracheiphila. Phytochemistry, 32: 865-867.
33. Rosfarizan, M., and Ariff, A.B. 2000. Kinetics of kojic acid fermentation by Aspergillus flavus using different types and concentrations of carbon and nitrogen sources. J. Ind. Microbiol. Biotechnol. 25: 20-24.
34. Schwartz, R., Liesch, J., Hensens, O., Zitano, L., Honeycutt, S., Garrity, G., Fromtling, R., Onishi, J., and Monaghan, R. 1988. L-657-398, a novel antifungal agent: fermentation, isolation, structural elucidation and biological properties. J. Antibiot. 41: 1774-1779.
35. Stander, M.A., Bornscheuer, U.T., Henke, E., and Steyn, P.S. 2000. Screening of commercial hydrolases for the degradation of ochratoxin A. J. Agric. Food Chem. 48: 5736-5739.
36. Tang, L., Zhang, Y.X., and Hutchinson, C.R. 1994. Amino acid catabolism and antibiotic synthesis: valine is source for precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. J. Bacteriol. 176: 6107-6119.
37. Telma, E.B., Willibaldo, S., Alfredo, E.M., Janice, C., and Jorge, A.V.C. 2003. Influence of carbon, nitrogen and phosphorous sources on glucoamylase production by Aspergillus awamori in solid state fermentation. Z. Naturforsch. 58c: 708-712.
38. Untrau, S., Lebrihi, A., Lefebvre, G., and Germain, P. 1994. Nitrogen catabolite regulation of spiramycin production in Streptomyces ambofaciens. Curr. Microbiol. 28: 111-118.