Gene expression and adiposity are modified by soy protein in male zucker diabetic fatty rats

Obesity Research

Volumn 12, Issue 12, 2004, Pages 1907-1913

  Banz, William J ^a   Davis, Jeremy ^a   Peterson, Richard ^b   Iqbal, Muhammad J ^a  

^a SOUTHERN ILLINOIS UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adiposity; Gene expression; Metabolic syndrome; Soy; Zucker diabetic fatty rat

Indexed keywords

GLYCINE MAX; RATTUS;

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; CASEIN; ISOFLAVONE DERIVATIVE; LIPID; MESSENGER RNA; ROSIGLITAZONE; SOYBEAN PROTEIN;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BLOOD; BODY COMPOSITION; CHEMISTRY; COMPARATIVE STUDY; DIABETES MELLITUS; DIET; DRUG EFFECT; GENE EXPRESSION; GENETICS; LIVER; MALE; OBESITY; ORGAN SIZE; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PROTEIN INTAKE; RAT; ZUCKER RAT;

ADIPOSE TISSUE; ANIMALS; BODY COMPOSITION; CASEINS; DIABETES MELLITUS; DIET; DIETARY PROTEINS; GENE EXPRESSION; HYPOGLYCEMIC AGENTS; ISOFLAVONES; LIPIDS; LIVER; MALE; OBESITY; ORGAN SIZE; POLYMERASE CHAIN REACTION; RATS; RATS, ZUCKER; RNA, MESSENGER; SOYBEAN PROTEINS; THIAZOLIDINEDIONES;

EID: 18944403547     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2004.238     Document Type: Article

References (24)

1. Liu K. Soybeans: Chemistry, Technology and Utilization. Aspen Publishers, Inc.: Gaithersburg, MD; 1999.
2. Erdman JW Jr., Fordyce EJ. Soy products and the human diet. Am J Clin Nutr. 1989;49:725-37. (Pubitemid 19139771)
3. Anderson JW, Johnstone BM, Cook-Newell ME. Metaanalysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995;333:276-82.
4. Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA, Shay N. Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr. 2003;133:1238-43. (Pubitemid 36548688)
5. Peluso MR, Winters TA, Shanahan MF, Banz WJ. A cooperative interaction between soy protein and its isoflavoneenriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. J Nutr. 2000;130:2333-42.
6. Iqbal MJ, Yaegashi S, Ahsan R, Lightfoot DA, Banz WJ. Differentially abundant mRNAs in rat liver in response to diets containing soy protein isolate. Physiol Genomics. 2002; 11:219-26. (Pubitemid 37128738)
7. Iritani N, Hosomi H, Fukuda H, Tada K, Ikeda H. Soybean protein suppresses hepatic lipogenic enzyme gene expression in Wistar fatty rats. J Nutr. 1996;126:380-8. (Pubitemid 26060530)
8. Tovar AR, Ascencio C, Torres N. Soy protein, casein, and zein regulate histidase gene expression by modulating serum glucagon. Am J Physiol Endocrinol Metab. 2002;283:E1016-22. (Pubitemid 35216961)
9. Ascencio C, Torres N, Isoard-Acosta F, Gomez-Perez FJ, Hernandez-Pando R, Tovar AR. Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J Nutr. 2004;134:522-9. (Pubitemid 38298490)
10. Unger RH, Orci L. Disease of liporegulation: new perspective on obesity and related disorders. FASEB J. 2001;15:312-21. (Pubitemid 32141423)
11. Unger RH. Lipotoxic diseases. Annu Rev Med. 2002;53:319-36. (Pubitemid 34177884)
12. Zhou YT, Shimabukuro M, Wang MY, et al. Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proc Natl Acad Sci USA. 1998;95:8898-903. (Pubitemid 28350586)
13. Rieusset J, Auwerx J, Vidal H. Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes. Biochem Biophys Res Commun. 1999;265:265-71.
14. Fabris R, Nisoli E, Lombardi AM, et al. Preferential channeling of energy fuels towards fat rather than muscle during high free fatty acid availability in rats. Diabetes. 2001;50: 601-8. (Pubitemid 32195225)
15. Chen M, Haluzik M, Wolf NJ, et al. Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearance. Endocrinology. 2004;145:4094-4102. (Pubitemid 39120557)
16. Sulzle A, Hirche F, Eder K. Thermally oxidized dietary fat upregulates the expression of target genes of PPAR alpha in rat liver. J Nutr. 2004;134:1375-83. (Pubitemid 38720709)
17. Au CS, Wagner A, Chong T, Qiu W, Sparks JD, Adeli K. Insulin regulates hepatic apolipoprotein B production independent of the mass or activity of Akt1/PKBalpha. Metabolism. 2004;53:228-35. (Pubitemid 38168896)
18. Qi L, Shen H, Larson I, Barnard JR, Schaefer EJ, Ordovas JM. Genetic variation at the hormone sensitive lipase: gender-specific association with plasma lipid and glucose concentrations. Clin Genet. 2004;65:93-100. (Pubitemid 38220109)
19. Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans. 2003;31: 1120-4. (Pubitemid 38030921)
20. Challis BG, Coll AP, Yeo GS, et al. Mice lacking proopiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY (3-36).Proc Natl Acad Sci U S A. 2004;101:4695-700. (Pubitemid 38437473)
21. Brand CL, Sturis J, Gotfredsen CF, et al. Dual PPARalpha /gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats. Am J Physiol Endocrinol Metab. 2003;284:E841-54. (Pubitemid 36323879)
22. Dana SL, Hoener PA, Bilakovics JM, et al. Peroxisome proliferator- activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the Zucker diabetic fatty rat. Metabolism. 2001;50:963-971. (Pubitemid 32755014)
23. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497-509.
24. Fletcher MJ. A colorimetric method for estimating serum triglycerides. Clin Chem. 1968;22:393-7.