What promise: Does PCSK9 hold?

Journal of the American College of Cardiology

Volumn 45, Issue 10, 2005, Pages 1620-1621

  Kastelein, John J P ^a   Fouchier, Sigrid W ^a   Defesche, Joep C ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9; SERINE PROTEINASE; UNCLASSIFIED DRUG;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL METABOLISM; FAMILIAL HYPERCHOLESTEROLEMIA; GENE; GENE EXPRESSION; HUMAN; NOTE; PRIORITY JOURNAL;

EID: 18944392418     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2005.02.056     Document Type: Editorial

References (17)

1. J.L. Goldstein, M.S. Brown Familial hypercholesterolemia identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with overproduction of cholesterol Proc Natl Acad Sci USA 70 1973 2804 2809
2. M.S. Brown, P.G. Brannan, H.A. Bohmfalk Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells J Cell Physiol 85 1975 425 436
3. A. Endo, M. Kuroda, K. Tanzawa Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity FEBS Lett 72 1976 323 326
4. T.L. Innerarity, K.H. Weisgraber, K.S. Arnold Familial defective apolipoprotein B-100 low density lipoproteins with abnormal receptor binding Proc Natl Acad Sci USA 84 1987 6919 6923
5. T.L. Innerarity, R.W. Mahley, K.H. Weisgraber Familial defective apolipoprotein B-100 a mutation of apolipoprotein B that causes hypercholesterolemia J Lipid Res 31 1990 1337 1349
6. S. Yusuf, S. Hawken, S. Ounpuu INTERHEART study investigators Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study) case-control study Lancet 364 2004 937 952
7. M. Varret, J.P. Rabes, B. Saint-Jore A third major locus for autosomal dominant hypercholesterolemia maps to 1p34.1-p32 Am J Hum Genet 64 1999 1378 1387
8. M. Abifadel, M. Varret, J.P. Rabes Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Nat Genet 34 2003 154 156
9. S.N. Chen, C.M. Ballantyne, A.M. Gotto Jr., Y. Tan, J.T. Willerson, A.J. Marian A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis J Am Coll Cardiol 45 2005 1611 1619
10. K.M. Timms, S. Wagner, M.E. Samuels A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree Hum Genet 114 2004 349 353
11. T.P. Leren Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia Clin Genet 65 2004 419 422
12. K. Shioji, T. Mannami, Y. Kokubo Genetic variants in PCSK9 affect the cholesterol level in Japanese J Hum Genet 49 2004 109 114
13. G. Dubuc, A. Chamberland, H. Wassef Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia Arterioscler Thromb Vasc Biol 24 2004 1454 1459
14. D. Damgaard, J.M. Jensen, M.L. Larsen No genetic linkage or molecular evidence for involvement of the PCSK9, ARH or CYP7A1 genes in the familial hypercholesterolemia phenotype in a sample of Danish families without pathogenic mutations in the LDL receptor and apoB genes Atherosclerosis 177 2004 415 422
15. K.N. Maxwell, J.L. Breslow Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype Proc Natl Acad Sci USA 101 2004 7100 7105
16. S. Benjannet, D. Rhainds, R. Essalmani NARC-1/PCSK9 and its natural mutants zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol J Biol Chem 279 2004 48865 48875
17. S.W. Park, Y.A. Moon, J.D. Horton Post-transcriptional regulation of LDL receptor protein by proprotein convertase subtilisin/kexin type 9a (PCSK9) in mouse liver J Biol Chem 279 2004 50630 50638