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Volumn 14, Issue 4, 1999, Pages 180-188

Treatment of Alzheimer's disease: Acetylcholinesterase enzyme inhibitors;Tratamiento de la enfermedad de Alzheimer: Farmacos inhibidores de la enzima acetilcolinesterasa

Author keywords

Alzheimer; Donepezil; Metriphonate; Rivastigmine; Treatment

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DONEPEZIL; METRIFONATE; RIVASTIGMINE;

EID: 18844482214     PISSN: 02134853     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (63)
  • 1
    • 0031964036 scopus 로고    scopus 로고
    • Relationship between plaques, tangles and loss of cortical cholinergic fibers in Alzheimer's disease
    • Geula C, Mesulam MM, Saroff DM, Wu CK. Relationship between plaques, tangles and loss of cortical cholinergic fibers in Alzheimer's disease. J Neuropathol Exp Neurol 1998; 57: 63-75.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 63-75
    • Geula, C.1    Mesulam, M.M.2    Saroff, D.M.3    Wu, C.K.4
  • 2
    • 0002037940 scopus 로고
    • Cholinergic systems and related neuropathological predilection patterns in Alzheimer disease
    • Terry RD, Katzman R, Bick KL, editores. Nueva York: Raven Press
    • Geula C, Mesulam MM. Cholinergic systems and related neuropathological predilection patterns in Alzheimer disease. En: Terry RD, Katzman R, Bick KL, editores. Alzheimer disease. Nueva York: Raven Press, 1994: 263-291.
    • (1994) Alzheimer Disease , pp. 263-291
    • Geula, C.1    Mesulam, M.M.2
  • 3
    • 0027511796 scopus 로고
    • Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease
    • Lehericy S, Hirsch EC, Cervera-Piérot P, Hersch LB, Cakchine S, Piette F et al. Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease. J Comp Neurol 1993; 330: 15-31.
    • (1993) J Comp Neurol , vol.330 , pp. 15-31
    • Lehericy, S.1    Hirsch, E.C.2    Cervera-Piérot, P.3    Hersch, L.B.4    Cakchine, S.5    Piette, F.6
  • 4
    • 0023247155 scopus 로고
    • Alzheimer's disease: Neurofibrillary tangles in nuclei that project to the cerebral cortex
    • German DC, White CL III, Sparkman DR. Alzheimer's disease: neurofibrillary tangles in nuclei that project to the cerebral cortex. Neuroscience 1987; 21: 305-312.
    • (1987) Neuroscience , vol.21 , pp. 305-312
    • German, D.C.1    White III, C.L.2    Sparkman, D.R.3
  • 5
    • 0027251358 scopus 로고
    • Differential localization of NADPH-Diaphprase and calbindin-D28k within the cholinergic neurons of the basal forebrain, striatum and brainstem in the rat, monkey, baboon and human
    • Geula C, Shatz CR, Mesulam MM. Differential localization of NADPH-Diaphprase and calbindin-D28k within the cholinergic neurons of the basal forebrain, striatum and brainstem in the rat, monkey, baboon and human. Neuroscience 1993; 54: 461-476.
    • (1993) Neuroscience , vol.54 , pp. 461-476
    • Geula, C.1    Shatz, C.R.2    Mesulam, M.M.3
  • 6
    • 0025994795 scopus 로고
    • The medial temporal lobe memory system
    • Squire LR, Zola-Morgan S. The medial temporal lobe memory system. Science 1991; 253: 1.380-1.386.
    • (1991) Science , vol.253 , pp. 1380-1386
    • Squire, L.R.1    Zola-Morgan, S.2
  • 7
    • 0031148292 scopus 로고    scopus 로고
    • The effects of selective cholinergic basal forebrain lesions and aging upon expectancy in the rat
    • Stoehr JD, Mobley SL, Roice D, Brooks R, Baker LM, Wiley RG et al. The effects of selective cholinergic basal forebrain lesions and aging upon expectancy in the rat. Neurobiol Learn Mem 1997; 67: 214-227.
    • (1997) Neurobiol Learn Mem , vol.67 , pp. 214-227
    • Stoehr, J.D.1    Mobley, S.L.2    Roice, D.3    Brooks, R.4    Baker, L.M.5    Wiley, R.G.6
  • 8
    • 0002392724 scopus 로고    scopus 로고
    • Current cholinergic therapy for symptoms of Alzheimer's disease
    • Doraiswamy PM. Current cholinergic therapy for symptoms of Alzheimer's disease. Primary Psychiatry 1996; 3: 3-11.
    • (1996) Primary Psychiatry , vol.3 , pp. 3-11
    • Doraiswamy, P.M.1
  • 10
    • 0005024110 scopus 로고
    • Cholinesterase and anticholinesterase agents
    • Berlín: Springer-Verlag
    • Koelle GB, editor. Cholinesterase and anticholinesterase agents. Handbook of experimental pharmacology. Vol. 15. Berlín: Springer-Verlag, 1963.
    • (1963) Handbook of Experimental Pharmacology , vol.15
    • Koelle, G.B.1
  • 11
    • 0032296920 scopus 로고    scopus 로고
    • Tratamiento médico de la enfermedad de Alzheimer
    • López-Pousa S, Serra-Mestres J. Tratamiento médico de la enfermedad de Alzheimer. Rev Neurol 1998; 26: 1.054-1.060.
    • (1998) Rev Neurol , vol.26 , pp. 1054-1060
    • López-Pousa, S.1    Serra-Mestres, J.2
  • 12
    • 0031880348 scopus 로고    scopus 로고
    • Pharmacologic treatment of cognition in Alzheimer's dementia
    • Farlow MR, Evans RM. Pharmacologic treatment of cognition in Alzheimer's dementia. Neurology 1998; 51 (Supl 1): S36-S44.
    • (1998) Neurology , vol.51 , Issue.1 SUPPL.
    • Farlow, M.R.1    Evans, R.M.2
  • 13
    • 0016823810 scopus 로고
    • Mini-mental state. A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 14
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984; 141: 1.356-1.364.
    • (1984) Am J Psychiatry , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2    Davis, K.L.3
  • 15
    • 0030958347 scopus 로고    scopus 로고
    • The neuropsychiatric inventory: Assessing psychopathology in dementia patients
    • Cummings JL. The neuropsychiatric inventory: assessing psychopathology in dementia patients. Neurology 1997; 48 (Supl 6): S10-S16.
    • (1997) Neurology , vol.48 , Issue.6 SUPPL.
    • Cummings, J.L.1
  • 18
    • 0008941101 scopus 로고
    • July 7, 1989. Rockville MD: Department of Health and Human Services, Publi Health Service; Food and Drug Administration
    • Peripheral and central nervous system drugs advisory Commitee Meeting. July 7, 1989. Rockville MD: Department of Health and Human Services, Publi Health Service; Food and Drug Administration, 1989; 227.
    • (1989) Peripheral and Central Nervous System Drugs Advisory Commitee Meeting , pp. 227
  • 19
    • 0014313861 scopus 로고
    • The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
    • Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Brit J Psychiatry 1968; 114: 797-811.
    • (1968) Brit J Psychiatry , vol.114 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.E.2    Roth, M.3
  • 20
    • 0345467172 scopus 로고
    • Measurement of quality-of-life changes in patients with Alzheimer's disease
    • DeJong R, Osterlund OW, Roy GW. Measurement of quality-of-life changes in patients with Alzheimer's disease. Clin Ther 1988; 139: 1.136-1.139.
    • (1988) Clin Ther , vol.139 , pp. 1136-1139
    • DeJong, R.1    Osterlund, O.W.2    Roy, G.W.3
  • 23
    • 0000557157 scopus 로고
    • E2020: The pharmacology of a piperidine cholinesterase inhibitor
    • Becker R, Giacobini E, editores. Boston: Birkhäuser
    • Rogers SL, Yamanishi Y, Yamatsu K. E2020: the pharmacology of a piperidine cholinesterase inhibitor. En: Becker R, Giacobini E, editores. Cholinergic basis for Alzheimer therapy. Boston: Birkhäuser, 1991; 314-320.
    • (1991) Cholinergic Basis for Alzheimer Therapy , pp. 314-320
    • Rogers, S.L.1    Yamanishi, Y.2    Yamatsu, K.3
  • 24
    • 0029127347 scopus 로고
    • Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-([5,6-dimethoxy-1 -indanon]-2-yl)methylpiperidine hydrochloride (E2020)
    • Nochi S, Asakawa N, Sato T. Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-([5,6-dimethoxy-1 -indanon]-2-yl)methylpiperidine hydrochloride (E2020). Biol Pharm Bull 1995; 18: 1.145-.1.147.
    • (1995) Biol Pharm Bull , vol.18 , pp. 1145-1147
    • Nochi, S.1    Asakawa, N.2    Sato, T.3
  • 25
    • 0027230486 scopus 로고
    • Pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy male volunteers
    • Mihara M, Ohnishi A, Tomono Y. Pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy male volunteers. Int J Clin Pharmacol Ther Toxicol 1993; 31: 223-229.
    • (1993) Int J Clin Pharmacol Ther Toxicol , vol.31 , pp. 223-229
    • Mihara, M.1    Ohnishi, A.2    Tomono, Y.3
  • 26
    • 0025163917 scopus 로고
    • Inhibitory action of E2020, a novel acetylcholinesterase inhibitor, on cholinesterase in aged rats
    • Yamanishi Y, Ogura H, Kosasa T. Inhibitory action of E2020, a novel acetylcholinesterase inhibitor, on cholinesterase in aged rats [resumen]. Eur J Pharmacol 1990; 183: 1.935.
    • (1990) Eur J Pharmacol , vol.183 , pp. 1935
    • Yamanishi, Y.1    Ogura, H.2    Kosasa, T.3
  • 27
    • 0012304548 scopus 로고
    • The pharmacokinetics (PK) and pharmacodynamics (PD) of E2020 ([R, S]-1-benzyl-4-[[5,6-dimethoxy-1-indanon]-2-yl]methylpiperidine hydrochloride), a novel inhibitor of acetylcholinesterase (Ache): Implications for use in the treatment of Alzheimer's disease
    • Rogers SL, Walters EJ, Friedhoff LT. The pharmacokinetics (PK) and pharmacodynamics (PD) of E2020 ([R, S]-1-benzyl-4-[[5,6-dimethoxy-1-indanon]-2-yl]methylpiperidine hydrochloride), a novel inhibitor of acetylcholinesterase (Ache): implications for use in the treatment of Alzheimer's disease [resumen]. Neurobiol Aging 1992; 13: 496.
    • (1992) Neurobiol Aging , vol.13 , pp. 496
    • Rogers, S.L.1    Walters, E.J.2    Friedhoff, L.T.3
  • 28
    • 0027141935 scopus 로고
    • Comparison of the pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy young and elderly subjects
    • Ohnishi A, Mihara M, Kamakura H. Comparison of the pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy young and elderly subjects. J Clin Pharmacol 1993; 33: 1.086-1.091.
    • (1993) J Clin Pharmacol , vol.33 , pp. 1086-1091
    • Ohnishi, A.1    Mihara, M.2    Kamakura, H.3
  • 29
    • 0345665606 scopus 로고    scopus 로고
    • The pharmacokinetics profile of donepezil HCL (E2020) in patients with imparied liver function
    • Tiseo PJ, Rogers SL, Friedhoff LT. The pharmacokinetics profile of donepezil HCL (E2020) in patients with imparied liver function. Clin Pharmacol Ther 1997; 61: 184.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 184
    • Tiseo, P.J.1    Rogers, S.L.2    Friedhoff, L.T.3
  • 30
    • 0000664373 scopus 로고    scopus 로고
    • Pharmacokinetics of donepezil HCL (E2020) are unchanged in patients with imparied renal function
    • Rogers SL, Tiseo PJ, Friedhoff LT. Pharmacokinetics of donepezil HCL (E2020) are unchanged in patients with imparied renal function. Clin Pharmacol Ther 1997; 61: 217.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 217
    • Rogers, S.L.1    Tiseo, P.J.2    Friedhoff, L.T.3
  • 32
    • 10244259208 scopus 로고    scopus 로고
    • The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicentre, randomized, double-blind, placebo-controlled trial
    • Rogers SL, Friedhoff LT, Donepezil study group. The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicentre, randomized, double-blind, placebo-controlled trial. Dementia 1996; 7: 293-303.
    • (1996) Dementia , vol.7 , pp. 293-303
    • Rogers, S.L.1    Friedhoff, L.T.2
  • 33
    • 0001220714 scopus 로고
    • Clinical benefits are maintained during long-treatment of Alzheimer's disease with the acetylcholinesterase inhibitor, E2020
    • Rogers SL, Perdomo C, Friedhoff LT. Clinical benefits are maintained during long-treatment of Alzheimer's disease with the acetylcholinesterase inhibitor, E2020 [resumen]. Neuropsychopharmacol 1995; 5: 386-387.
    • (1995) Neuropsychopharmacol , vol.5 , pp. 386-387
    • Rogers, S.L.1    Perdomo, C.2    Friedhoff, L.T.3
  • 34
    • 0031883716 scopus 로고    scopus 로고
    • A 24-week, double-bind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
    • Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT, The Donepezil Study Group. A 24-week, double-bind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Neurology 1998; 50: 136-145.
    • (1998) Neurology , vol.50 , pp. 136-145
    • Rogers, S.L.1    Farlow, M.R.2    Doody, R.S.3    Mohs, R.4    Friedhoff, L.T.5
  • 35
    • 0008079097 scopus 로고    scopus 로고
    • Co-administration of donepezil HCl and digoxin produces no pharmacokinetics of pharmacodynamic interactions
    • Tiseo PJ, Rogers SL, Friedhoff LT. Co-administration of donepezil HCl and digoxin produces no pharmacokinetics of pharmacodynamic interactions. Neuropsychopharmacol 1997; 7 (Supl 2): 4.024.
    • (1997) Neuropsychopharmacol , vol.7 , Issue.2 SUPPL. , pp. 4024
    • Tiseo, P.J.1    Rogers, S.L.2    Friedhoff, L.T.3
  • 36
    • 0008039585 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of (R)-and (S)-warfarin are unaffected by co-administration of donepezil HCl
    • Tiseo PJ, Rogers SL, Friedhoff LT. The pharmacokinetics and pharmacodynamics of (R)-and (S)-warfarin are unaffected by co-administration of donepezil HCl. Eu Neuropsychopharmacol 1997; 7 (Supl 2): 4.023.
    • (1997) Eu Neuropsychopharmacol , vol.7 , Issue.2 SUPPL. , pp. 4023
    • Tiseo, P.J.1    Rogers, S.L.2    Friedhoff, L.T.3
  • 37
    • 0029766994 scopus 로고    scopus 로고
    • Efficacy and safety results of the early phase studies with Exelon (ENA-713) in Alzheimer's disease: An overview
    • Anand R, Gharabawi G, Enz A. Efficacy and safety results of the early phase studies with Exelon (ENA-713) in Alzheimer's disease: an overview. J Drug Dev Clin Pract 1996; 8: 1-8.
    • (1996) J Drug Dev Clin Pract , vol.8 , pp. 1-8
    • Anand, R.1    Gharabawi, G.2    Enz, A.3
  • 38
    • 0029778789 scopus 로고    scopus 로고
    • Clinical Development of Exelon (ENA-713): The ADENA programme
    • Anand R, Gharabawi G. Clinical Development of Exelon (ENA-713): the ADENA programme. J Drug Dev Clin Pract 1996; 8: 9-14.
    • (1996) J Drug Dev Clin Pract , vol.8 , pp. 9-14
    • Anand, R.1    Gharabawi, G.2
  • 40
    • 0344364399 scopus 로고
    • New Jersey: Sandoz Research Institute
    • a ed.). New Jersey: Sandoz Research Institute, 1994.
    • (1994) a Ed.)
  • 41
    • 0345659011 scopus 로고    scopus 로고
    • The ADENa programme: International coordinated phase III development of a second generation of acetylcholinesterase inhibitor (SDZ ENA-713)
    • Edimburgo: The Challenge of the Dementias. April 25-26
    • Anand R, Gharabawi G. The ADENA programme: international coordinated phase III development of a second generation of acetylcholinesterase inhibitor (SDZ ENA-713). Poster presented at the Lancet Conference. Edimburgo: The Challenge of the Dementias. April 25-26, 1996.
    • (1996) Lancet Conference
    • Anand, R.1    Gharabawi, G.2
  • 42
    • 0008434623 scopus 로고    scopus 로고
    • Sandoz Alzheimer's drug "impressive"
    • 2.132
    • Sandoz Alzheimer's drug "impressive". Scrip 1996; 2.132: 22.
    • (1996) Scrip , pp. 22
  • 43
    • 0029917179 scopus 로고    scopus 로고
    • Safety/tolerability trial of SDZ ENA 713 in patients with probable Alzheimer's disease
    • Sramek JJ, Anand R, Wardle TS, Irwin P, Hartman RD, Cutler NR. Safety/tolerability trial of SDZ ENA 713 in patients with probable Alzheimer's disease. Life Sci 1996; 58: 1.201-1.207.
    • (1996) Life Sci , vol.58 , pp. 1201-1207
    • Sramek, J.J.1    Anand, R.2    Wardle, T.S.3    Irwin, P.4    Hartman, R.D.5    Cutler, N.R.6
  • 44
    • 0008434260 scopus 로고    scopus 로고
    • Promising results with Sandoz' Exelon in Alzheimer's
    • 2.512
    • Promising results with Sandoz' Exelon in Alzheimer's. Scrip 1996; 2.512: 22.
    • (1996) Scrip , pp. 22
  • 48
    • 0026586537 scopus 로고
    • Psychiatric diagnosis and uncooperative behavior in nursing homes
    • Aronson MK, Stella CD, German P. Psychiatric diagnosis and uncooperative behavior in nursing homes. J Geriatr Psychiatry Neurol 1992; 5: 102-105.
    • (1992) J Geriatr Psychiatry Neurol , vol.5 , pp. 102-105
    • Aronson, M.K.1    Stella, C.D.2    German, P.3
  • 49
    • 0029863987 scopus 로고    scopus 로고
    • Metrifonate and dichlorvos: Effects of a single oral administration on cholinesterase activity in rat brain and blood
    • Hinz V, Grewing S, Schmidt BH. Metrifonate and dichlorvos: effects of a single oral administration on cholinesterase activity in rat brain and blood. Neurochem Res 1996; 21: 339-345.
    • (1996) Neurochem Res , vol.21 , pp. 339-345
    • Hinz, V.1    Grewing, S.2    Schmidt, B.H.3
  • 50
    • 0031842292 scopus 로고    scopus 로고
    • Metrifonate treatment of the cognitive deficits of Alzheimer's Disease
    • Cummings J, Cyrus PA, Bieber F, Mas J, Orazem J, Gulanski B. Metrifonate treatment of the cognitive deficits of Alzheimer's Disease. Neurology 1998; 50: 1.214-1.221.
    • (1998) Neurology , vol.50 , pp. 1214-1221
    • Cummings, J.1    Cyrus, P.A.2    Bieber, F.3    Mas, J.4    Orazem, J.5    Gulanski, B.6
  • 51
    • 0023899578 scopus 로고
    • Mechanisms of cholinesterase inhibition in senile dementia of the Alzheimer type: Clinical, pharmacological and therapeutic aspects
    • Becker RE, Giacobini E, Mechanisms of cholinesterase inhibition in senile dementia of the Alzheimer type: clinical, pharmacological and therapeutic aspects. Drug Develop Res 1988; 12: 163-195.
    • (1988) Drug Develop Res , vol.12 , pp. 163-195
    • Becker, R.E.1    Giacobini, E.2
  • 52
    • 0023576685 scopus 로고
    • Modulation of brain acetylcoline levels with cholinesterase inhibitors as a treatment of Alzheimer disease
    • Giacobini E. Modulation of brain acetylcoline levels with cholinesterase inhibitors as a treatment of Alzheimer disease. Keio J Med 1987; 36: 381-391.
    • (1987) Keio J Med , vol.36 , pp. 381-391
    • Giacobini, E.1
  • 53
    • 0023226136 scopus 로고
    • A comparison of the effects of two inhibitors on brain cholinesterase
    • Hallak M, Giacobini E. A comparison of the effects of two inhibitors on brain cholinesterase. Neuropharmacology 1987; 26: 521-530.
    • (1987) Neuropharmacology , vol.26 , pp. 521-530
    • Hallak, M.1    Giacobini, E.2
  • 54
    • 0025272542 scopus 로고
    • Effects of metrifonate, a long-acting cholinesterase inhibitor, in Alzheimer disease: Report of an open trial
    • Becker RE, Colliver J, Elble R, Feldman E, Giacobini E, Kumar V et al. Effects of metrifonate, a long-acting cholinesterase inhibitor, in Alzheimer disease: report of an open trial. Drug development research 1990; 19: 425-434.
    • (1990) Drug Development Research , vol.19 , pp. 425-434
    • Becker, R.E.1    Colliver, J.2    Elble, R.3    Feldman, E.4    Giacobini, E.5    Kumar, V.6
  • 56
    • 0029744529 scopus 로고    scopus 로고
    • Effects of metrifonate, a cholinesterase inhibitor, on local cerebral glucose utilization in young and aged rats
    • Bassant MH, Jazat-Poindessous F, Lamour Y. Effects of metrifonate, a cholinesterase inhibitor, on local cerebral glucose utilization in young and aged rats. J Cereb Blood Flow Metab 1996; 16: 1.014-1.025.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 1014-1025
    • Bassant, M.H.1    Jazat-Poindessous, F.2    Lamour, Y.3
  • 59
    • 0342688218 scopus 로고    scopus 로고
    • Metrifonate in Alzheimer's disease: Results of a dose-finding study
    • Iqbal K, Winblad B, Nishimura T, Takeda M. Wisniewski, editores. John Wiley & Sons Ltd.
    • Cummings J, Mas J, Orazem J, Gulanski B. Metrifonate in Alzheimer's disease: results of a dose-finding study. En: Iqbal K, Winblad B, Nishimura T, Takeda M. Wisniewski, editores. Alzheimer's disease: biology, diagnosis and therapeutics. John Wiley & Sons Ltd., 1997; 665-669.
    • (1997) Alzheimer's Disease: Biology, Diagnosis and Therapeutics , pp. 665-669
    • Cummings, J.1    Mas, J.2    Orazem, J.3    Gulanski, B.4
  • 60
    • 0031842293 scopus 로고    scopus 로고
    • Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's Disease
    • Morris JC, Cyrus PA, Orazem J, Mas J, Bieber F, Ruzicka BB et al. Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's Disease. Neurology 1998; 50: 1.222-1.1230.
    • (1998) Neurology , vol.50 , pp. 1222-11230
    • Morris, J.C.1    Cyrus, P.A.2    Orazem, J.3    Mas, J.4    Bieber, F.5    Ruzicka, B.B.6
  • 61
    • 0031896251 scopus 로고    scopus 로고
    • Metrifonate: Overview of safety and efficacy
    • Cummings J. Metrifonate: overview of safety and efficacy. Pharmacotherapy 1998; 18: 43-46.
    • (1998) Pharmacotherapy , vol.18 , pp. 43-46
    • Cummings, J.1
  • 63
    • 0023612349 scopus 로고
    • Clinical experience with metrifonate
    • Feldmeier H, Doehring E. Clinical experience with metrifonate. Acta Tropica 1987; 44: 357-368.
    • (1987) Acta Tropica , vol.44 , pp. 357-368
    • Feldmeier, H.1    Doehring, E.2


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