Effects of combined estrogen/testosterone therapy on bone and body composition in oophorectomized women

Gynecological Endocrinology

Volumn 20, Issue 3, 2005, Pages 155-160

  Floter A ^a   Nathorst Boos J ^a   Carlstrom K ^a   Ohlsson, C ^b   Ringertz, H ^a   Von Schoultz, B ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Androgens; Body composition; Bone markers; Bone mineral density; HT; Menopause; Testosterone

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; ANABOLIC AGENT; ANTIHISTAMINIC AGENT; ANTILIPEMIC AGENT; BARBITURIC ACID DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CARBAMAZEPINE; CARBOXY TERMINAL TELOPEPTIDE; CORTICOSTEROID; DANAZOL; ESTRADIOL VALERATE; ESTROGEN; GRISEOFULVIN; HERBACEOUS AGENT; HYDANTOIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; OSTEOCALCIN; PLACEBO; PROCOLLAGEN; PROPEPTIDE OF TYPE 1 PROCOLLAGEN; RIFAMPICIN; SEX HORMONE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; TESTOSTERONE UNDECANOATE; TRANQUILIZER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD PRESSURE; BODY COMPOSITION; BODY FAT; BODY MASS; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; ESTROGEN THERAPY; FEMALE; HIP; HUMAN; HYSTERECTOMY; LEAN BODY WEIGHT; MENOPAUSE; OVARIECTOMY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SPINE;

BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; DOUBLE-BLIND METHOD; ESTRADIOL; FEMALE; HUMANS; HYSTERECTOMY; INSULIN-LIKE GROWTH FACTOR I; MIDDLE AGED; OSTEOCALCIN; OVARIECTOMY; PEPTIDE FRAGMENTS; PLACEBOS; PROCOLLAGEN; PROSPECTIVE STUDIES; TESTOSTERONE;

EID: 18844448726     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.1080/09513590400021193     Document Type: Article

References (46)

1. Michaelsson K, Baron JA, Farahmand BY. Hormone replacement therapy and risk of hip fracture: population-based case-control study. Br Med J 1998;316:1858-1863.
2. Lufkin EG, Wahner HW, O'Fallon WM. Treatment of postmenopausal osteoporosis with transdermal estrogen. Ann Intern Med 1994;117:1-9.
3. Ortolani S, Trevisan C, Bianchi ML. Spinal and forearm bone mass in relation to ageing and menopause in healthy Italian women. Eur J Clin Invest 1991;21:33-39.
4. Vanderschueren D, Vandenput L, Boonen S. Androgens and bone. Endocr Rev 2004;25:389-425.
5. Lindsay R, Hart DM, Forrest C. Prevention of spinal osteoporosis in oophorectomised women. Lancet 1980;2:1151-1154.
6. Genant HK, Cann CE, Ettinger B. Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 1982;97:699-705.
7. Judd HL, Judd GE, Lucas EE. Endocrine function of the postmenopausal ovary: concentrations of androgens and estrogens in ovarian and peripheral vein blood. J Endocrinol Metab 1974;39:1020-1024.
8. Davis SR, McCloud PI, Strauss BJG. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227-236.
9. Shifren, JL, Braunstein GD, Simon JA. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343:682-688.
10. Flöter A, Nathorst-Böös J, Carlström K. Addition of testosterone to estrogen replacement therapy in oophorectomized women: effects on sexuality and well-being. Climacteric 2002;5:357-365.
11. Davidson BJ, Ross RK, Paganini-Hill A. Total and free estrogens and androgens in postmenopausal women with hip fractures. J Clin Endocrinol Metab 1982;54:115-120.
12. Longcope C, Baker RS, Hui SL. Androgen and estrogen dynamics in women with vertebral crush fractures. Maturitas 1984;6:309-318.
13. Garnett T, Studd JWW, Watson N. The effects of plasma oestradiol levels on increases in vertebral and femoral bone density following therapy with oestradiol and oestradiol with testosterone implants. Obstet Gynecol 1992;79:968-972.
14. Watts NB, Notelovitz M, Timmons MC. Comparison of oral estrogens and estrogen plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause. Obstet Gynecol 1995;85:529-537.
15. Barrett-Connor E, Young R, Notelovitz M. A two-year double-blind comparison of estrogen-androgen and conjugated estrogens in surgically PM women: effects on bone mineral density, symptoms and lipid profiles. J Reprod Med 1999;44:1012-1020.
16. Raisz LG, Wiita B, Anis A. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab 1996;81:37-43.
17. Colvard DS, Eriksen EF, Keeting PE. Identification of androgen receptors in normal human osteoblast-like cells. Proc Nad Acad Sci USA 1989;86:854-887.
18. Sands RH, Studd JWW, Jones J. Comparison of the biochemical effects of testosterone and estrogen on bone markers in surgically postmenopausal women. Gynecol Endocrinol 2000;14:382-387.
19. Risteli J, Elomaa I, Niemi S. Radioimmunoassay for the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clin Chem 1993;39:635-640.
20. Melkko J, Kauppila S, Niemi S. Immunoassay for the intact aminoterminal propeptide of human type I procollagen. Clin Chem 1996;42:947-954.
21. Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995;332:305-311.
22. Clemmons D. Editorial: role of insulin-like growth factor-I in reversing catabolism. J Clin Endocrinol Metab 1992;75:1183-1185.
23. Morales AJ, Nolan JJ, Nelson JC. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994;78:1360-1367.
24. Blum WF, Ranke MB. Plasma IGFBP-3 levels as clinical indicators. In: Spencer EM, editor. Modern concepts of insulin-like growth factors. New York: Elsevier Science Publishing; 1991. pp 381-393.
25. Davis SR, Walker KZ, Strauss BJG. Effects of estradiol with and without testosterone on body composition and relationships with lipids in postmenopausal women. Menopause 2000;7:395-401.
26. Lapidus L, Bengtsson C, Björntorp P. The quantitative relationship between the metabolic syndrome and abdominal obesity in women. Obes Res 1994;2:372-387.
27. Horst HJ, Höltje WJ, Dennis M. Lymphatic absorption and metabolism of orally administered testosterone undecanoate in man. Klin Wochenschr 1976;54:875-879.
28. Shackleford DM, Faassen WA, Houwing N. Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs. J Pharmacol Exp Ther 2003;306:925-933.
29. Flöter A, Nathorst-Böös J, Carlström K. Serum lipids in oophorectomized women during estrogen and testosterone replacement therapy. Maturitas 2004;47:123-129.
30. Södergard R, Bäckström T, Shanbag V. Calculation of free and bound fractions of testosterone and estradiol-17β to plasma proteins at body temperature. J Steroid Biochem 1982;18:801-804.
31. Brismar TB, Ringertz H. Effect on bone density of the head on total body DEXA measurements in 100 healthy Swedish women. Acta Radiol 1996;37:101-106.
32. Notelovitz M. Effects of estrogen/androgen therapy on bone mineral density parameters. J Reprod Med 2001;46:325-331.
33. Gruber DM, Sator MO, Kirchengast S. Effects of percutaneous replacement therapy on body composition and body weight in postmenopausal women. Maturitas 1998;29:253-259.
34. Dobs AS, Nguyen T, Pace C. Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab 2002;87:1509-1516.
35. Abrahamsen B, Bonnevie-Nielsen V, Ebbesen EN. Cytokines and bone loss in a 5-year longitudinal study-hormone replacement therapy suppresses serum soluble interleukin-6 receptor and increases interleukin-1 receptor antagonist: the Danish Osteoporosis Prevention Study. J Bone Miner Res 2000;15:1545-1554.
36. Ohta H, Makita K, Suda Y. Influence of oophorectomy on serum levels of sex steroids and bone metabolism and assessment of bone mineral density in lumbar trabecular bone by QCT-C value. J Bone Miner Res 1992;7:659-665.
37. Kassem M, Okazaki R, Harris SA. Estrogen effects on insulin-like growth factor gene expression in a human osteoblastic cell line with high levels of estrogen receptor. Calcif Tissue Int 1998;62:60-66.
38. Wreje U, Brynhildsen J, Åberg H. Collagen metabolism markers as a reflection of bone and soft tissue turnover during the menstrual cycle and oral contraceptive use. Contraception 2000;61:265-270.
39. Brodsky IG, Balagopal P, Nair KS. Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men - a clinical research center study. J Clin Endocrinol Metab 1996;81:3469-3475.
40. Douchi T, Yamamoto S, Nakamura S. The effect of menopause on regional and total body lean mass. Maturitas 1998;29:247-252.
41. Guo SS, Zeller C, Chumlea WC. Aging, body composition and lifestyle: the Pels Longitudinal Study. Am J Clin Nutr 1999;70:405-411.
42. Lovejoy JC, Bray GA, Bourgeois MO. Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women - a clinical research center study. J Clin Endocrinol Metab 1996;81:2198-2203.
43. Wahab M, Ballard P, Purdie DW. The effect of long-term estradiol implantation on bone mineral density in postmenopausal women who have undergone hysterectomy and bilateral oophorectomy. Br J Obstet Gynaecol 1997;104:728-731.
44. Khastgir G, Studd J, Holland N. Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: histomorphometric evidence in a longitudinal study. J Clin Endocrinol Metab 2001;86:289-295.
45. Ortmann J, Prifti S, Bohlmann MK. Testosterone and 5 alpha- dihydrotestosterone inhibit in vitro growth of human breast cancer cell lines. Gynecol Endocrinol 2002;16:113-120.
46. Dimitrakakis C, Zhou J, Wang J. A physiological role for testosterone in limiting estrogenic stimulation of the breast. Menopause 2003;10:292-298.