RacGap50C negatively regulates wingless pathway activity during drosophila embryonic development

Genetics

Volumn 169, Issue 4, 2005, Pages 2075-2086

  Jones, Whitney M ^a   Bejsovec, Amy ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; DROSOPHILA PROTEIN; PROTEIN RACGAP50C; UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 PROTEIN;

ARMADILLO; ARTICLE; CELL FATE; DROSOPHILA; EMBRYO DEVELOPMENT; ENZYME REGULATION; EPIDERMIS CELL; GENE EXPRESSION; GENE MUTATION; INSECT DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION;

ALLELES; ANIMALS; ARMADILLO DOMAIN PROTEINS; BODY PATTERNING; CROSSES, GENETIC; DROSOPHILA PROTEINS; EPIDERMIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GREEN FLUORESCENT PROTEINS; GTPASE-ACTIVATING PROTEINS; IN SITU HYBRIDIZATION; MUTATION; PHENOTYPE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; RNA; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSGENES; WING;

ANIMALIA; ARMADILLO;

EID: 18844448691     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.104.039735     Document Type: Article

References (50)

1. ADAMS, M. D., S. E. CELNIKER, R. E. HOLT, C. A. EVANS, J. D. GOCAYNE et al., 2000 The genome sequence of Drosophila melanogaster. Science 287: 2185-2195.
2. ASHBURNER, M., 1989 Drosophila: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
3. BEJSOVEC, A., and A. MARTINEZ-ARIAS, 1991 Roles of wingless in patterning the larval epidermis of Drosophila. Development 113: 471-485.
4. BEJSOVEC, A., and E. WIESCHAUS, 1993 Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development 119: 501-517.
5. BEJSOVEC, A., and E. WIESCHAUS, 1995 Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. Genetics 139: 309-320.
6. BERGERET, E., I. PIGNOT-PAINTRAND, A. GUICHARD, K. RAYMOND, M. O. FAUVARQUE et al., 2001 RotundRacGAP functions with Ras during spermatogenesis and retinal differentiation in Drosophila melanogaster. Mol. Cell. Biol. 21: 6280-6291.
7. BERNARDS, A., 2003 GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim. Biophys. Acta 1603: 47-82.
8. BRUNNER, E., O. PETER, L. SCHWEIZER and K. BASLER, 1997 pangolin encodes a Lef-1 homolog that acts downstream of Armadillo to transduce the Wingless signal. Nature 385: 829-833.
9. CADIGAN, K. M., and R. NUSSE, 1997 Wnt signaling: a common theme in animal development. Genes Dev. 11: 3286-3305.
10. CHAO, A. T., H. A. DIERICK, T. M. ADDY and A. BEJSOVEC, 2003 Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. Genetics 165: 601-612.
11. CHEN, B., T. CHU, E. HARMS, J. P. GERGEN and S. STRICKLAND, 1998 Mapping of Drosophila mutations using site-specific male recombination. Genetics 149: 157-163.
12. CLIFFE, A., F. HAMADA and M. BIENZ, 2003 A role of Dishevelled in recruiting Axin to the plasma membrane during Wingless signaling. Curr. Biol. 13: 960-966.
13. DIERICK, H. A., and A. BEJSOVEC, 1998 Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling. Development 125: 4729-4738.
14. DIERICK, H., and A. BEJSOVEC, 1999 Cellular mechanisms of Wingless/Wnt signaling activity. Curr. Top. Dev. Biol. 43: 153-190.
15. DINARDO, S., E. SHER, J. HEEMSKERK-JONGENS, J. A. KASSIS and P. O'FARRELL, 1988 Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature 322: 604-609.
16. FEHON, R. G., I. A. DAWSON and S. ARTAVANIS-TSAKONAS, 1994 A Drosophila homolog of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development 120: 545-557.
17. HAKEDA-SUZUKI, S., J. NG, J. TZU, G. DIETZL, Y. SUN et al., 2002 Rac function and regulation during Drosophila development. Nature 416: 438-442.
18. HALL, A., 1998 Rho GTPases and the actin cytoskeleton. Science 279: 509-514.
19. HAMADA, F., Y. TOMOYASU, Y. TAKATSU, M. NAKAMURA, S. NAGAI et al., 1999 Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science 283: 1739-1742.
20. HARDEN, N., M. RICOS, Y. M. ONG, W. CHIA and L. LIM, 1999 Participation of small GTPases in dorsal closure of the Drosophilaembryo: distinct roles for Rho subfamily members in epithelial morphogenesis. J. Cell Sci. 112: 273-284.
21. JONES, W. M., and A. BEJSOVEC, 2003 Wingless signaling: an axin to grind. Curr. Biol. 13: R479-R481.
22. JÜRGENS, G., E. WIESCHAUS, C. NÜSSLEIN-VOLHARD and H. KLUDING, 1984 Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. II. Zygotic loci on the third chromosome. Roux's Arch. Dev. Biol. 193: 283-295.
23. LOGAN, C. Y., and R. NUSSE, 2004 The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20: 781-810.
24. LOHS-SCHARDIN, M., C. CREMER and C. NÜSSLEIN-VOLHARD, 1979 A fate map for the larval epidermis of Drosophila melanogaster: localized cuticle defects following irradiation of the blastoderm with a UV laser microbeam. Dev. Biol. 73: 239-255.
25. LUO, L., Y. J. LIAO, L. Y. JAN and Y. N. JAN, 1994 Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8: 1787-1802.
26. MAGIE, C. R., M. R. MEYER, M. S. GORSUCH and S. M. PARKHURST, 1999 Mutations in the Rhol small GTPase disrupt morphogenesis and segmentation during early Drosophila development. Development 126: 5353-5364.
27. MARTINEZ ARIAS, A., N. BAKER and P. INGHAM, 1988 Role of the segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. Development 103: 157-170.
28. MCCARTNEY, B. M., H. A. DIERICK, C. KIRKPATRICK, M. M. MOLINE, A. BAAS et al., 1999 Drosophila APC2 is a cytoskeletally-associated protein that regulates Wingless signaling in the embryonic epidermis. J. Cell Biol. 146: 1303-1318.
29. MCCARTNEY, B. M., D. G. MCEWEN, E. GREVENGOED, P. MADDOX, A. BEJSOVEC et al., 2001 Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nat. Cell Biol. 3: 933-938.
30. MOLINE, M. M., C. SOUTHERN and A. BEJSOVEC, 1999 Directionality of Wingless protein transport influences epidermal patterning in the Drosophila embryo. Development 126: 4375-4384.
31. MOLINE, M. M., H. A. DIERICK, C. SOUTHERN and A. BEJSOVEC, 2000 Non-equivalent roles of Drosophila Frizzled and Frizzled2 in embryonic Wingless signal transduction. Curr. Biol. 10: 1127-1130.
32. NG, J., T. NARDINE, M. HARMS, J. TZU, A. GOLDSTEIN et al., 2002 Rac GTPases control axon growth, guidance and branching. Nature 416: 442-447.
33. NOORDERMEER, J., P. JOHNSTON, F. RIJSEWIJK, R. NUSSE and P. A. LAWRENCE, 1992 The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo. Development 116: 711-719.
34. NÜSSLEIN-VOLHARD, C., E. WIESCHAUS and H. KLUDING, 1984 Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster: I. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193: 267-282.
35. O'KEEFE, L., S. T. DOUGAN, L. GABAY, E. RAZ, B.-Z. SHILO et al., 1997 Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. Development 124: 4837-4845.
36. PEIFER, M., and P. POLAKIS, 2000 Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 287: 1606-1609.
37. PEIFER, M., D. SWEETON, M. CASEY and E. WIESCHAUS, 1994 wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120: 369-380.
38. RIGGLEMAN, B., E. WIESCHAUS and P. SCHEDL, 1989 Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene. Genes Dev. 3: 96-113.
39. RIGGLEMAN, B., P. SCHEDL and E. WIESCHAUS, 1990 Spatial expression of the Drosophila segment polarity gene armadillo is post-transcriptionally regulated by wingless. Cell 63: 549-560.
40. ROUSSET, R., J. MACK, K. WHARTON, J. AXELROD, K. CADIGAN et al., 2001 naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev. 15: 658-671.
41. SIEGFRIED, E., T. CHOU and N. PERRIMON, 1992 wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell 71: 1167-1179.
42. SOMERS, W. G., and R. SAINT, 2003 A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis. Dev. Cell 4: 29-39.
43. SOTILLOS, S., and S. CAMPUZANO, 2000 DRacGap, a novel Drosophila gene inhibits EGFR/Ras signalling in the developing imaginal wing disc. Development 127: 5427-5438.
44. SZUTS, D., M. FREEMAN and M. BIENZ, 1997 Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila. Development 124: 3209-3219.
45. TAUTZ, D., and C. PFEIFLE, 1989 A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98: 81-85.
46. TOLWINSKI, N. S., M. WEHRLI, A. RIVES, N. ERDENIZ, S. DINARDO et al., 2003 Wg/Wnt signal can be transmitted through Arrow/LRP5,6 and Axin independently of Zw3/Gsk3 activity. Dev. Cell 4: 407-418.
47. VAN DE WETERING, M., R. CAVALLO, D. DOOIJES, M. VAN BEEST, J. VAN ES et al., 1997 Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88: 789-799.
48. WIESCHAUS, E., and C. NŪSSLEIN-VOLHARD, 1986 Looking at embryos, pp. 199-227 in Drosophila: A Practical Approach, edited by D. B. ROBERTS. IRL Press, Oxford.
49. WODARZ, A., and R. NUSSE, 1998 Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 14: 59-88.
50. ZENG, W., K. A. J. WHARTON, J. A. MACK, K. WANG, M. GADBAW et al., 2000 naked cuticle encodes an inducible antagonist of Wnt signalling. Nature 402: 789-795.