Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells

Thrombosis and Haemostasis

Volumn 93, Issue 5, 2005, Pages 810-815

  Artwohl, Michaela ^a   Hölzebein, Thomas ^a   Fürnsinn, Clemens ^a   Freudenthaler, Angelika ^a   Huttary, Nicole ^a   Waldhäusl, Werner Klaus ^a   Baumgartner Parzer, Sabina M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; Endothelium; Heat shock protein 60; PPAR agonists; Thiazolidinediones

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; APOPTOSIS INHIBITOR; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; HEAT SHOCK PROTEIN 60; MYC PROTEIN; NETOGLITAZONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIOGLITAZONE; PROSTAGLANDIN J2; PROTEIN BCL 2; ROSIGLITAZONE; STEARIC ACID; TRANSCRIPTION FACTOR E2F1; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

AORTA; APOPTOSIS; ARTICLE; CELL TYPE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAPHENOUS VEIN; STRUCTURE ACTIVITY RELATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

AORTA; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; CHAPERONIN 60; CHROMANS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; HYPOGLYCEMIC AGENTS; LIGANDS; MICROSCOPY, PHASE-CONTRAST; MITOCHONDRIA; PPAR GAMMA; PROSTAGLANDIN D2; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; THIAZOLIDINEDIONES; TIME FACTORS; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA; VON WILLEBRAND FACTOR;

EID: 18844420861     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH04-09-0615     Document Type: Article

References (18)

1. Plutzky J, Viberti G, Haffner S. Atherosclerosis in type 2 diabetes mellitus and insulin resistance: Mechanistic links and therapeutic targets. J Diabetes Compl 2002; 16: 401-15.
2. Plutzky J. Peroxisome proliferator-activated receptors in endothelial biology. Curr Opin Lipidol 2001; 12: 511-8.
3. Artwohl M, Fürnsinn C, Waldhäusl W, et al. Thiazolidinediones inhibit proliferation of micro- and macrovascular cells by a PPARγ-independent mechansims. Diabetologia 2005; 48: 586-94.
4. Theocharis S, Margeli A, Vielh P, et al. Peroxisome proliferator-activated receptor-gamma ligands as cell-cycle modulators. Cancer Treat Rev 2004; 30: 545-54.
5. Erl W, Weber C, Zernecke A, et al. Cyclopentenone prostaglandins induce endothelial cell apoptosis independent of the peroxisome proliferator-activated receptor-γ. Eur J Immunol 2004; 34: 241-50.
6. 2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells. Am J Physiol Heart Circ Physiol 2003; 285: H38-H46.
7. Chen J, Li D, Zhang X, et al. Tumor necrosis factor-α-induced apoptosis of human coronary artery endothelial cells: Modulation by the peroxisome proliferator-activated receptor-γ ligand pioglitazone. J Cardiovasc Pharmacol Ther 2004; 9: 35-41.
8. Artwohl M, Hölzenbein T, Wagner L, et al. Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol 2000; 131: 1577-83.
9. Artwohl M, Graier WF, Roden M, et al. Diabetic LDL triggers apoptosis in vascular endothelial cells. Diabetes 2003; 52: 1240-7.
10. Artwohl M, Roden M, Waldhäusl W, et al. Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells. FASEB J 2004; 18: 146-8.
11. Chen J, Li D, Zhang X, Mehta JL. Tumor necrosis factor-α-induced apoptosis of human coronary artery endothelial cells: modulation by the peroxisome-proliferator-activated receptor-γ ligand pioglitazone. J Cardiovasc Pharmacol Ther 2004; 9: 35-41.
12. Choy JC, Granville DJ, Hunt DWC, et al. Endothelial cell apoptosis: Biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol 2001; 33: 1673-90.
13. 2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells. Br J Cancer 2002; 87: 1396-403.
14. 2 but not by troglitazone. J Dent Res 2003; 82: 802-6.
15. Tanaka H, Matsumura I, Ezoe S, et al. E2F1 and c-myc potentiate apoptosis through inhibition of NF-κB activity that facilitates MnSOD-mediated ROS elimination. Mol Cell 2002; 9: 1017-29.
16. Niculescu F, Niculescu T, Rus H. C5b-9 terminal complement complex assembly on apoptotic cells in human arterial wall with atherosclerosis. Exp Mol Pathol 2004; 76: 17-23.
17. Kleindienst R, Xu Q, Willeit J, et al. Demonstration of heat shock protein 60 expression and T-lymphocytes bearing α/β or γ/δ receptor in human atherosclerotic lesions. Am J Pathol 1993; 142: 1927-37.
18. Hannan KM, Dilley RJ, de Dios ST, et al. Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta. Arterioscler Thromb Vasc Biol 2003; 23: 762-8.