Mechanism-based modeling of reduced inotropic responsiveness to digoxin in endotoxemic rat hearts

European Journal of Pharmacology

Volumn 514, Issue 1, 2005, Pages 43-51

  Baek, Myoungki ^a   Weiss, Michael ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Cardiac glycoside; Endotoxin; Mathematical modeling; Na+ K+ ATPase; Sepsis

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; DIGOXIN; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG UPTAKE; ENDOTOXEMIA; FEVER; INOTROPISM; MALE; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BODY TEMPERATURE; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; HEART; HEART VENTRICLES; LIPOPOLYSACCHARIDES; MALE; MODELS, BIOLOGICAL; MYOCARDIAL CONTRACTION; MYOCARDIUM; RATS; RATS, WISTAR; SODIUM-CALCIUM EXCHANGER; THIOUREA;

EID: 18844419261     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.03.020     Document Type: Article

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