Inotropic response to endothelin-1, isoprenaline and calcium in cardiomyocytes isolated from endotoxin treated rats: Effects of ethyl-isothiourea and dexamethasone

British Journal of Pharmacology

Volumn 130, Issue 6, 2000, Pages 1275-1282

  Spiers, J P ^a,b   Kelso, E J ^a   Allen, J D ^a   Silke, B ^a   McDermott, B J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ST JAMES S HOSPITAL   (Ireland)

Author keywords

Calcium; Cardiomyocyte; Contraction; Dexamethasone; Endothelin; Endotoxic shock; Ethyl isothiourea; Isoprenaline; Lipopolysaccharide

Indexed keywords

CALCIUM; DEXAMETHASONE; ENDOTHELIN 1; ENDOTOXIN; ISOPRENALINE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; SODIUM CHLORIDE; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SIZE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIDEORECORDING;

EID: 0033913859     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703435     Document Type: Article

References (39)

1. BALLIGAND, J.-L., UNGUREANU, D., KELLY, R.A., KOBZIK, L., PIMENTAL, D., MICHEL, T. & SMITH, T.W. (1993). Abnormal contractile function due to induction of nitric oxide synthesis in rat myocytes follows exposure to activated macrophage-conditioned medium. J. Clin. Invest., 91, 2314-2319.
2. BATTISTINI, B., FORGET, M.A. & LAIGHT, D. (1996). Potential roles for endothelins in systemic inflammatory response syndrome with a particular relationship to cytokines. Shock, 5, 167-183.
3. BONE, R.C. (1991). The pathogenesis of sepsis. Ann. Intern. Med., 115, 457-469.
4. BRADY, A.B.J., POOLE-WILSON, P.A., HARDING, S.E. & WARREN, J.B. (1992). Nitric oxide production within cardiac myocytes reduces their contractility in endotoxaemia. Am. J. Physiol., 263, H1963-H1966.
5. CHOMCZYNSKI, P. & SACCHI, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
6. CHUNG, M.K., GULICK, T., ROTONDO, R.E., SCHREINER, G.F. & LANGE, L.G. (1990). Mechanism of cytokine inhibition of β-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Circ. Res., 67, 753-763.
7. DECKING, U.K.M., FLESCHE, C.W. & GÖDECKE, A. & SCHRADER, J. (1995). Endotoxin-induced contractile dysfunction in guinea pig hearts is not mediated by nitric oxide. Am. J. Physiol., 268, H2460-H2465.
8. DI ROSA, M., RADOMSKI, M., CARNUCCIO, R. & MONCADA, S. (1990). Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem. Biophys. Res. Commun., 172, 1246-1252.
9. FINKEL, M.S., ODDIS, C.V., JACOBS, T.D,. WATKINS, S.C., HATTLER, B.G. & SIMMONS, R.L. (1992). Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science, 257, 387-389.
10. GARDINER, S.M., KEMP, P.A., MARCH, J.E. & BENNETT, D. (1995). Enhancement of the hypotensive and vasodilator effects of endotoxaemia in conscious rats by the endothelin antagonist, SB 209670. Br. J. Pharmacol., 116, 1718-1719.
11. GULICK, T., CHUNG, M.K., PIEPER, S.J., LANGE, L.G. & SCHREINER, G.F. (1989). Interleukin 1 and tumour necrosis factor inhibit cardiac myocyte β-adrenergic responsiveness. Proc. Natl. Acad. Sci. U.S.A., 86, 6753-6757.
12. HAHN, P.Y., WANG, P., TAIT, S.M., BA, Z.F., REICH, S.S. & CHAUDRY, I.H. (1995). Sustained elevation in circulating catecholamine levels during polymicrobial sepsis. Shock, 4, 269-273.
13. ISHIKAWA, K., YANAGISAWA, M., KIMURA, S. GOTO, K. & MASAKI, T. (1988). Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. Am. J. Physiol., 255, H973.
14. ISHIWATA, T., GUO, F., NAITO, Z., ASANO, G. & NISHIGAKI, R. (1997). Differential distribution of ecNOS and iNOS mRNA in rat heart after endotoxin administration. Jpn. Heart J., 38, 445-455.
15. KELLER, R.S., JONES, J.J., KIM, K.F., & MYERS, P.R., ADAMS, R.H., PARKER, J.L. & RUBIN, L.J. (1995). Endotoxin-induced myocardial dysfunction: Is there a role for nitric oxide? Shock, 4, 338-344.
16. KELSO, E.J., McDERMOTT, B.J. & SILKE, B. (1995). Actions of the novel vasodilator, flosequinan, in isolated ventricular cardiomyocytes. J. Cardiovasc. Pharmacol., 25, 376-386.
17. KLABUNDE, R E. & COSTON, A.F. (1995). Nitric oxide synthase inhibition does not prevent cardiac depression in endotoxic shock. Shock, 3, 73-78.
18. MATTHEWS, J.N.S., ALTMAN, D.G., CAMPBELL, M.J. & ROYSTON, P. (1990). Analysis of serial measurements in medical research. Br. Med. J., 300, 230-235.
19. MULLER-WERDAN, U., SCHUMANN, H., FUCHS, R., REITHMANN, C., LOPPNOW, H., KOCH, S., ZIMNY-ARNDT, U., HE, C., DARMER, D., JUNGBLUT, P., STADLER, J., HOLTZ, J. & WERDAN, K. (1997). Tumour necrosis factor α (TNFα) is cardiodepressant in pathophysiologically relevant concentrations without inducing inducible nitric oxide-(NO)-synthase (iNOS) or triggering serious cytotoxicity. J. Mol. Cell. Cardiol., 29, 2915-2923.
20. NATANSON, C., DANNER, R.L. & FINK, M.P. (1988). Cardiovascular performance with E. coli challenges in a canine model of human sepsis. Am. J. Physiol., 254, H558-H569.
21. NATANSON, C., HOFFMAN, W.D., SUFFREDINI, A.F., EICHACKER, P.Q. & DANNER, R.L. (1994). Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann. Intern. Med., 120, 771-783.
22. PARKER, M.M., SHELHAMER, J.H., BACHARACH, S.L., GREEN, M.V., NATANSON, C., FREDERICK, T.M., DAMSKE, B.A. & PARRILLO, J.E. (1984). Profound but reversible myocardial depression in patients with septic shock. Ann. Intern. Med., 100, 483-490.
23. PARRATT, J.R. (1998). Nitric oxide in sepsis and endotoxaemia. J. Antimicrob. Chemother., 41, 31-39.
24. PITTET, J.F., MOREL, D.R., HAMSEN, A., GUNNING, K., LACROIX, J.S., SUTER, P.M. & LUNDBERG, J.M. (1991). Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis. Ann. Surg., 213, 261-264.
25. RADOMSKI, M., PALMER, R.M.J. & MONCADA, S. (1990). Glucocorticoids inhibit the expression of an inducible, but not constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. U.S.A., 87, 10043-10047.
26. 2+ -independent nitric oxide synthases. FEBS Lett., 291, 145-149.
27. SOUTHAN, G.J., SZABO, C. & THIERMANN, C. (1995). Isothioureaspotent inhibitors of nitric-oxide synthases with variable isoform selectivity. Br. J. Pharmacol., 114, 510-516.
28. SULAKHE, P.V., SANDIRASEGARANE, L., DAVIS, J.P., VO, X.T. & MAINRA, R.R. (1996). Alterations in inotropy, nitric oxide and cyclic GMP synthesis, protein phosphorylation and ADP-ribosylation in the endotoxin-treated rat myocardium and cardiomyocytes. Mol. Cell. Biochem., 163/164, 305-318.
29. SUN, X., WEI, S., SZABO, C. & DUSTING, G.J. (1997). Depression of the inotropic action of isoprenaline by nitric oxide synthase induction in rat isolated hearts. Eur. J. Pharmacol., 320, 29-35.
30. SZABO, C. & THIEMERMANN, C. (1995). Regulation of the expression of the inducible isoform of nitric oxide synthase. Adv. Pharmacol., 34, 113-153.
31. THOMAS, P.B., LIU, E.C.K., WEBB, M.L., MUKHERJEE, R., HEBBAR, L. & SPINALE, F.G. (1996). Exogenous effects and endogenous production of endothelin in cardiac myocytes: potential significance in heart failure. Am. J. Physiol., 271, H2629-H2637.
32. TOTH, I. & HEARD, S.O. (1997). Nitric oxide does not mediate lipopolysaccharide-induced myocardial depression in guinea pigs. Crit. Care Med., 25, 684-688.
33. UNGUREANU-LONGROIS, D., BALLIGAND, J.-L., KELLY, R.A., & SMITH, T.W. (1995). Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of cytokine-inducible nitric oxide synthase in cardiac myocytes. J. Mol. Cell. Cardiol., 27, 155-167.
34. VANDECASTEELE, G., ESCHENHAGEN, T., SCHOLZ, H., STEIN, B., VERDE, I. & FISCHMEISTER, R. (1999). Muscarinic and β-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase. Nature Med., 5, 331-334.
35. YASUDA, S. & LEW, W.Y. (1997a). Endothelin-1 ameliorates contractile depression by lipopolysaccharide in cardiomyocytes. Am. J. Physiol., 273, H1402-H1407.
36. 2+ in cardiac myocytes. Circ. Res., 81, 1011-1020.
37. YOKOYAMA, T., VACA, L., ROSSEN, R.D., DURANTE, W., HAZARIKA, P. & MANN, D.L. (1993). Cellular basis for the negative inotropic effects of tumour necrosis factor-α in the adult mammalian heart. J. Clin. Invest., 92, 2303-2312.
38. 2+ concentration and contraction-relaxation properties of ventricular myocytes from Escherichia Coli endotoxaemic guinea pigs: Effect of fluid resuscitation. Shock, 7, 383-388.
39. ZHONG, J., HWANG, T.C., ADAMS, H.R. & RUBIN, L.J. (1997b). Reduced L-type calcium current in ventricular myocytes from endotoxaemic guinea pigs. Am. J. Physiol., 42, H2312-H2324.