Reduced basal activity and increased functional homogeneity in sensorimotor and striatum of a Parkinson's disease rat model: A functional MRI study

European Journal of Neuroscience

Volumn 21, Issue 8, 2005, Pages 2227-2232

  Pelled, Galit ^a   Bergman, Hagai ^b   Ben Hur, Tamir ^a   Goelman, Gadi ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

6 OHDA; fMRI; Parkinson's disease; Physiological noise; Rat

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL GANGLION; CONTROLLED STUDY; CORPUS STRIATUM; FUNCTIONAL MAGNETIC RESONANCE IMAGING; MALE; NERVE CONDUCTION; NERVE FUNCTION; NERVE STIMULATION; NEUROIMAGING; NON INVASIVE MEASUREMENT; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SENSORIMOTOR CORTEX; SENSORIMOTOR FUNCTION;

ADRENERGIC AGENTS; ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; FUNCTIONAL LATERALITY; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NEURAL NETWORKS (COMPUTER); OXIDOPAMINE; OXYGEN; PARKINSON DISEASE; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SOMATOSENSORY CORTEX;

EID: 18844404379     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04035.x     Document Type: Article

References (41)

1. Albin, R.L., Young, A.B. & Penney, J.B. (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci., 12, 366-375.
2. Araki, T., Tanji, H., Kato, H. & Itoyama, Y. (1998) Sequential changes of dopaminergic receptors in the rat brain after 6- hydroxydopamine lesions of the medial forebrain bundle. J. Neurol. Sci. 160, 121-127.
3. Austin, V.C., Blamire, A.M., Allers, K.A., Sharp, T., Styles, P., Matthews, P.M. & Sibson, N.R. (2005) Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia. Neuroimage, 24, 92-100.
4. Biswal, B., Van Kylen, J. & Hyde, J.S. (1997) Simultaneous assessment of flow and BOLD signals in resting-state functional connectivity maps. NMR Biomed., 10, 165-170.
5. Biswal, B., Yetkin, F.Z., Haughton, V.M. & Hyde, J.S. (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn. Reson. Med., 34, 537-541.
6. Brooks, D.J. (1999) Functional imaging of Parkinson's disease: is it possible to detect brain areas for specific symptoms? J. Neural Transm. Suppl., 56, 139-153.
7. Buchel, C. & Friston, K.J. (1997) Modulation of connectivity in visual pathways by attention: cortical interactions evaluated with structural equation modelling and fMRI. Cereb. Cortex, 7, 768-778.
8. Buchel, C. & Friston, K.J. (1998) Dynamic changes in effective connectivity characterized by variable parameter regression and Kalman filtering. Hum. Brain Mapp., 6, 403-408.
9. Carlson, J.D., Pearlstein, R.D., Buchholz, J., Iacono, R.P. & Maeda, G. (1999) Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson's model rats. Brain Res., 828, 12-19.
10. Catalan, M.J., Ishii, K., Honda, M., Samii, A. & Hallett, M. (1999) A PET study of sequential finger movements of varing length in patients with Parkinson's disease. Brain, 122, 483-495.
11. DeLong, M.R. (1990) Primate model of movement disorders of the basal ganglia origin. Trends Neurosci., 13, 281-285.
12. Elsworth, J.D., Deutch, A.Y., Redmond, D.E. Jr, Sladek, J.R. Jr & Roth, R.H. (1990) MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neurosci. Lett., 114, 316-322.
13. Gerfen, C.R. & Wilson, C.J. (1996) The basal ganglia. In Swanson, L.W., Bjurklund, A. & Hokfelt, T. (Eds), Handbook of Chemical Neuroanatomy. Elsevier Science, New York, pp. 371-468.
14. Goelman, G. (2004) Radial correlation contrast - a functional connectivity MRI contrast to map changes in local neuronal communication. Neuroimage, 23, 1432-1439.
15. Goldberg, J.A., Boraud, T., Maraton, S., Haber, S.N., Vaadia, E. & Bergman, H. (2002) Enhanced synchrony among primary motor cortex neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. J. Neurosci., 22, 4639-4653.
16. Heimer, G., Bar-Gad, I., Goldberg, J.A. & Bergman, H. (2002) Dopamine replacement therapy reverses abnormal synchronization of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of parkinsonism. J. Neurosci., 22, 7850-7855.
17. Hurtado, J.M., Gray, C.M., Tamas, L.B. & Sigvardt, K.A. (1999) Dynamics of tremor-related oscillations in the human globus pallidus: a single case study. Proc. Natl Acad. Sci. USA, 96, 1674-1679.
18. Hyder, F., Rothman, D.L. & Shulman, R.G. (2002) Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI. Proc. Natl Acad. Sci. USA, 99, 10771-10776.
19. Jahanshahi, M., Jenkins, I.H., Brown, R.G., Marsden, C.D., Passingham, R.E. & Brooks, D.J. (1995) Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects. Brain Res., 118, 913-933.
20. Jenkins, I.H., Fernandez, W., Playford, E.D., Lees, A.J., Frackowiak, R.S., Passingham, R.E. & Brooks, D.J. (1992) Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine. Ann. Neurol., 32, 749-757.
21. Krimer, L.S., Muly, E., 3rd, Williams, G.V. & Goldman-Rakic, P.S. (1998) Dopaminergic regulation of cerebral cortical microcirculation. Nat. Neurosci., 1, 286-289.
22. Kruger, G. & Glover, G.H. (2001) Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn. Reson. Med., 46, 631-637.
23. Levy, R., Hutchison, W.D., Lozano, A.M. & Dostrovsky, J.O. (2000) High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor. J. Neurosci., 20, 7766-7775.
24. Mink, J.W. & Thach, W.T. (1991) Basal ganglia motor control. I. Nonexclusive relation of pallidal discharge to five movement modes. J. Neurophysiol., 65, 273-300.
25. Palombo, E., Porrino, L.J., Bankiewicz, K.S., Crane, A.M., Kopin, I.J. & Sokoloff, L. (1988) Administration of MPTP acutely increases glucose utilization in the substantia nigra of primates. Brain Res., 453, 227-234.
26. Palombo, E., Porrino, L.J., Bankiewicz, K.S., Crane, A.M., Sokoloff, L. & Kopin, I.J. (1990) Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP. J. Neurosci., 10, 860-869.
27. Parent, A. & Hazrati, L.N. (1995) Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res. Rev., 20, 91-127.
28. Paxinos, G. & Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
29. Pelled, G., Bergman, H. & Goelman, G. (2002) Bilateral overactivation of the sensorimotor cortex in the unilateral rodent model of Parkinson's disease - a functional magnetic resonance imaging study. Eur. J. Neurosci., 15, 389-394.
30. Pelled, G. & Goelman, G. (2004) Different physiological MRI noise between cortical layers. Magn. Reson. Med., 52, 913-916.
31. Playford, E.D., Jenkins, I.H., Passingham, R.E., Nutt, J., Frackowiak, R.S. & Brooks, D.J. (1992) Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study. Ann. Neurol., 32, 151-161.
32. Rascol, O., Sabatini, U., Fabre, N., Brefel, C., Loubinoux, I., Clesis, P., Senard, J.M., Montastruc, J.L. & Chollet, F. (1997) The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients. Brain, 120, 103-110.
33. Sabatini, U., Boulanouar, K., Fabre, N., Martin, F., Carel, C., Colonnese, C., Bozzao, L., Berry, I., Montastruc, J.L., Chollet, F. & Rascole, O. (2000) Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study. Brain, 123, 394-403.
34. Scatton, B., Rouquier, L., Javoy-Agid, F. & Agid, Y. (1982) Dopamine deficiency in the cerebral cortex in Parkinson disease. Neurology, 32, 1039-1040.
35. Schwarting, R.K. & Huston, J.P. (1996) Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelae. Prog. Neurobiol., 49, 215-266.
36. Shulman, R.G., Hyder, F. & Rothman, D.L. (2001a) Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging. Proc. Natl Acad. Sci. USA, 98, 6417-6422.
37. Shulman, R.G., Hyder, F. & Rothman, D.L. (2001b) Lactate efflux and the neuroenergetic basis of brain function. NMR Biomed., 14, 389-396.
38. Small, S.A., Wu, E.X., Bratsch, D., Perera, G.M., Lacefield, C.O., DeLaPaz, R., Mayeux, R., Stem, Y. & Kandel, E.R. (2000) Imaging physiologic dysfunction of individual hippocampal subregions in human and genetically modified mice. Neuron, 28, 653-664.
39. Smith, A.J., Blumenfeld, H., Behar, K.L., Rothman, D.L., Shulman, R.G. & Hyder, F. (2002) Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI. Proc. Natl Acad. Sci. USA, 99, 10765-10770.
40. Thobois, S., Dominey, P., Decety, J., Pollak, P., Gregoire, M.C. & Broussolle, E. (2000) Overactivation of primary motor cortex is assymetrical in hemiparkinsonian patients. Neuroreport, 11, 785-789.
41. Yokoyama, C. & Okamura, H. (1997) Self-injurious behavior and dopaminergic neuron system in neonatal 6- hydroxydopamine-lesioned rat: 1. Dopaminergic neurons and receptors. J. Pharmacol. Exp. Ther., 280, 1016-1030.