Evidence for the involvement of glutamatergic system in the antinociceptive effect of ascorbic acid

Neuroscience Letters

Volumn 381, Issue 1-2, 2005, Pages 185-188

  Rosa, Kelson A ^a   Gadotti, Vinicius M ^a   Rosa, Angelo O ^b   Rodrigues, Ana Lúcia S ^b   Calixto, João B ^b   Santos, Adair R S ^a  

^a Depto de Ciê Fisiol   (Brazil)

^b Departamento de Farmacologia   (Brazil)

Author keywords

Ascorbic acid; Glutamate; Kainate; NMDA; Nociception; Substance P

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ASCORBIC ACID; FORMALDEHYDE; GLUTAMIC ACID; IONOTROPIC RECEPTOR; KAINIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID; SUBSTANCE P;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BITE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FEMALE; LICKING; MALE; MOLECULAR INTERACTION; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL;

EID: 18844386218     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.02.032     Document Type: Article

References (20)

1. A. Beirith, A.R. Santos, and J.B. Calixto Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw Brain Res. 924 2002 219 228
2. M.E. Fundytus Glutamate receptors and nociception: implications for the drug treatment of pain CNS Drugs 15 2001 29 58
3. J.L. Hylden, and G.L. Wilcox Intrathecal morphine in mice: a new technique Eur. J. Pharmacol. 67 1980 313 316
4. N.H. Jensen Reduced pain from osteoarthritis in hip joint or knee joint during treatment with calcium ascorbate. A randomized, placebo-controlled cross-over trial in general practice Ugeskr. Laeger. 165 2003 2563 2566
5. H. Liu, P.W. Mantyh, and A.L. Basbaum NMDA-receptor regulation of substance P release from primary afferent nociceptors Nature 386 1997 721 724
6. K. Lutfy, S.X. Cai, R.M. Woodward, and E. Weber Antinociceptive effects of NMDA and non-NMDA receptor antagonists in the tail flick test in mice Pain 70 1997 31 40
7. M.D. Majewska, J.A. Bell, and E.D. London Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate Brain Res. 537 1990 328 332
8. M.J. Millan The induction of pain: an integrative review Prog. Neurobiol. 57 1999 1 164
9. N. Mjellem-Joly, A. Lund, O.G. Berge, and K. Hole Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test Pain 51 1992 195 198
10. V. Neugebauer Metabotropic glutamate receptors - important modulators of nociception and pain behavioral Pain 98 2002 1 8
11. S. Ozawa, H. Kamiya, and K. Tsuzuki Glutamate receptors in mammalian central nervous system Prog. Neurobiol. 54 1998 581 618
12. G.V. Rebec, S.J. Barton, A.M. Marseilles, and K. Collins Ascorbate treatment attenuates the Huntington behavioral phenotype in mice Neuroreport 14 2003 1263 1265
13. G.V. Rebec, and R.C. Pierce A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission Prog. Neurobiol. 43 1994 537 565
14. M.E. Rice Ascorbate regulation and its neuroprotective role in the brain Trends Neurosci. 23 2000 209 216
15. A.R.S. Santos, and J.B. Calixto Further evidence for the involviment of tachykinins receptor subtypes on formalin and capsaicin models of pain in mice Neuropeptides 31 1997 381 389
16. C. Scheidt, A.R. Santos, J. Ferreira, A. Malheiros, V. Cechinel-Filho, R.A. Yunes, and J.B. Calixto Evidence for the involvement of glutamatergic receptors in the antinociception caused in mice by the sesquiterpene drimanial Neuropharmacology 43 2002 340 347
17. A. Tjølsen, O.G. Berge, S. Hunskaar, J.H. Rosland, and K. Hole The formalin test: an evaluation of the method Pain 51 1992 5 17
18. D.G. Trist Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications Pharm. Acta Helv. 74 2000 221 229
19. K. Wiech, R.T. Kiefer, S. Topfner, H. Preissl, C. Braun, K. Unertl, H. Flor, and N. Birbaumer A placebo-controlled randomized crossover trial of the N-methyl-d-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb pain Anesth. Analg. 98 2004 408 413
20. M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110