Renal vascular and glomerular fibrosis and epidermal growth factor receptor transactivation;Les effets profibrosants des peptides vasoactifs dans le rein et les vaisseaux passent-ils par la transactivation du facteur de croissance épidermique (EGF)?

Medecine/Sciences

Volumn 21, Issue 5, 2005, Pages 461-463

  Flamant, Martin ^a   Dussaule, Jean Claude ^a   Ardaillou, Raymond ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; A DISINTEGRIN AND METALLOPROTEASE; ANGIOTENSIN; ENDOTHELIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; N(G) NITROARGININE METHYL ESTER; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; QUINAZOLINE DERIVATIVE; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOGRAPHY; DIMERIZATION; DISEASE ACTIVITY; DISEASE COURSE; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; GLOMERULUS; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; KIDNEY BLOOD VESSEL; KIDNEY FIBROSIS; NONHUMAN; NOTE; PROTEIN PHOSPHORYLATION; RENOVASCULAR DISEASE;

GLOMERULUS;

EID: 18844379993     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/2005215461     Document Type: Note

References (9)

1. Flamant M, Tharaux PL, Placier S, et al. Epidermal growth factor receptor transactivation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J 2003; 17: 327-9.
2. 2+ channels activated by endothelin-1 in CHO cells expressing endothelin-A or endothelin-B receptors. J Neurosurg 2004; 100: 1066-71.
3. 2+ influx in afferent arterioles. Hypertension 2002; 40: 700-6.
4. Kagiyama S, Eguchi S, Frank GD, et al. Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation 2002; 106: 909-12.
5. Français H, Placier S, Flamant M, et al. Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. FASEB J 2004; 18: 926-8.
6. Shah B, Catt KJ. Matrix metalloproteinase-dependent EGF receptor activation in hypertension and left ventricular hypertrophy. Trends Endocrinol Metab 2004; 15: 241-3.
7. Shi-Wen X, Yunliang C, Denton CP, et al. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phospoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell 2004; 15: 2707-19.
8. Kelly DJ, Cox AJ, Gow RM, et al. Platelet-derived growth factor receptor transactivation mediates the trophic effects of angiotensin II in vivo. Hypertension 2004; 44: 1-8.
9. Asakura M, Kitakaze M, Nade K, et al. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nature 2002; 8: 35-40.