메뉴 건너뛰기




Volumn 765, Issue 2, 1997, Pages 343-348

Lysosomal generation of amyloid β protein species in transgenic mice

Author keywords

Alzheimer's disease; Amyloid protein; Amyloid protein precursor; Cathepsin D; Lysosome; Pancreas; Transgenic mouse

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CATHEPSIN D; ENZYME; SIGNAL PEPTIDE;

EID: 18744436124     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00695-1     Document Type: Article
Times cited : (7)

References (33)
  • 1
    • 0026695045 scopus 로고
    • Light and electron microscopic localization of β-amyloid protein in muscle biopsies of patients with inclusion-body myositis
    • V. Askanas, W.K. Engel, R.B. Alvarez, Light and electron microscopic localization of β-amyloid protein in muscle biopsies of patients with inclusion-body myositis, Am. J. Pathol. 141 (1992) 31-36.
    • (1992) Am. J. Pathol. , vol.141 , pp. 31-36
    • Askanas, V.1    Engel, W.K.2    Alvarez, R.B.3
  • 2
    • 0027407570 scopus 로고
    • Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells
    • J. Busciglio, D.H. Gabunza, P. Matsudaira, B.A. Yankner, Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells, Proc. Natl. Acad. Sci. USA 90 (1993) 2092-2096.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2092-2096
    • Busciglio, J.1    Gabunza, D.H.2    Matsudaira, P.3    Yankner, B.A.4
  • 3
    • 0027526419 scopus 로고
    • Release of excess amyloid β protein from a mutant amyloid β protein precursor
    • X.-D. Cai, T.E. Golde, S.G. Younkin, Release of excess amyloid β protein from a mutant amyloid β protein precursor, Science 259 (1993) 514-516.
    • (1993) Science , vol.259 , pp. 514-516
    • Cai, X.-D.1    Golde, T.E.2    Younkin, S.G.3
  • 4
    • 0025195944 scopus 로고
    • Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain
    • A.M. Cataldo, R.A. Nixon, Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain, Proc. Natl. Acad. Sci. USA 87 (1990) 3861-3865.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3861-3865
    • Cataldo, A.M.1    Nixon, R.A.2
  • 5
    • 0028220243 scopus 로고
    • Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease
    • A.M. Cataldo, D.J. Hamilton, R.A. Nixon, Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease, Brain Res. 640 (1994) 68-80.
    • (1994) Brain Res. , vol.640 , pp. 68-80
    • Cataldo, A.M.1    Hamilton, D.J.2    Nixon, R.A.3
  • 6
    • 0028947294 scopus 로고
    • Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
    • A.M. Cataldo, J.L. Barnett, S.A. Berman, J. Li, S. Quarless, S. Bursztajn, C. Lippa, R.A. Nixon, Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system, Neuron 14 (1995) 671-680.
    • (1995) Neuron , vol.14 , pp. 671-680
    • Cataldo, A.M.1    Barnett, J.L.2    Berman, S.A.3    Li, J.4    Quarless, S.5    Bursztajn, S.6    Lippa, C.7    Nixon, R.A.8
  • 8
    • 0023943263 scopus 로고
    • Cathepsin D is membrane-associated in macrophage endosomes
    • S. Diment, M.S. Leech, P.D. Stahl, Cathepsin D is membrane-associated in macrophage endosomes, J. Biol. Chem. 263 (1988) 6901-6907.
    • (1988) J. Biol. Chem. , vol.263 , pp. 6901-6907
    • Diment, S.1    Leech, M.S.2    Stahl, P.D.3
  • 10
    • 0028971529 scopus 로고
    • Candidate γ-secretases in the generation of the carboxyl-terminus of the Alzheimer's disease βa4 amyloid: Possible involvement of cathepsin D
    • G. Evin, R. Cappai, Q.-X. Li, J.G. Culvenor, D.H. Small, K. Beyreuther, C.L. Masters, Candidate γ-secretases in the generation of the carboxyl-terminus of the Alzheimer's disease βA4 amyloid: possible involvement of cathepsin D, Biochemistry 34 (1995) 14185-14192.
    • (1995) Biochemistry , vol.34 , pp. 14185-14192
    • Evin, G.1    Cappai, R.2    Li, Q.-X.3    Culvenor, J.G.4    Small, D.H.5    Beyreuther, K.6    Masters, C.L.7
  • 11
    • 0028980783 scopus 로고
    • Intracellular production of βA4 amyloid of Alzheimer's disease: Modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein
    • S.J. Fuller, E. Storey, Q.-X. Li, A.I. Smith, K. Beyreuther, C.L. Masters, Intracellular production of βA4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein, Biochemistry 34 (1995) 8091-8098.
    • (1995) Biochemistry , vol.34 , pp. 8091-8098
    • Fuller, S.J.1    Storey, E.2    Li, Q.-X.3    Smith, A.I.4    Beyreuther, K.5    Masters, C.L.6
  • 13
    • 0028915895 scopus 로고
    • Amyloid β protein (A β) in Alzheimer's disease brain: Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A β40 or A β42(43)
    • S.A. Gravina, L. Ho, C.B. Eckman, K.E. Long, L. Otvos Jr., L.H. Younkin, N. Suzuki, S.G. Younkin, Amyloid β protein (A β) in Alzheimer's disease brain: Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A β40 or A β42(43), J. Biol. Chem. 270 (1995) 7013-7016.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7013-7016
    • Gravina, S.A.1    Ho, L.2    Eckman, C.B.3    Long, K.E.4    Otvos L., Jr.5    Younkin, L.H.6    Suzuki, N.7    Younkin, S.G.8
  • 14
    • 0026735070 scopus 로고
    • Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
    • C. Haass, E.H. Koo, A. Mellon, A.Y. Hung, D.J. Selkoe, Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments, Nature 357 (1992) 500-503.
    • (1992) Nature , vol.357 , pp. 500-503
    • Haass, C.1    Koo, E.H.2    Mellon, A.3    Hung, A.Y.4    Selkoe, D.J.5
  • 16
    • 0027535111 scopus 로고
    • β-amyloid peptide and 3-kDa fragment are derived by distinct cellular mechanisms
    • C. Haass, A.Y. Hung, M.G. Schlossmacher, D.B. Teplow, D.J. Selkoe, β-amyloid peptide and 3-kDa fragment are derived by distinct cellular mechanisms, J. Biol. Chem. 268 (1993) 3021-3024.
    • (1993) J. Biol. Chem. , vol.268 , pp. 3021-3024
    • Haass, C.1    Hung, A.Y.2    Schlossmacher, M.G.3    Teplow, D.B.4    Selkoe, D.J.5
  • 17
    • 0027333557 scopus 로고
    • Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
    • C. Haass, D.J. Selkoe, Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide, Cell 75 (1993) 1039-1042.
    • (1993) Cell , vol.75 , pp. 1039-1042
    • Haass, C.1    Selkoe, D.J.2
  • 20
    • 0028169925 scopus 로고
    • Visualization of A β42(43) and A β40 in senile plaques with end-specific A β monoclonals: Evidence that an initially deposited species is A β42(43)
    • T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina, Y. Ihara, Visualization of A β42(43) and A β40 in senile plaques with end-specific A β monoclonals: evidence that an initially deposited species is A β42(43), Neuron 13 (1994) 45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 23
    • 0028276801 scopus 로고
    • Evidence that production and release of amyloid β-protein involves the endocytic pathway
    • E.H. Koo, S.L. Squazzo, Evidence that production and release of amyloid β-protein involves the endocytic pathway, J. Biol. Chem. 269 (1994) 17386-17389.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17386-17389
    • Koo, E.H.1    Squazzo, S.L.2
  • 24
    • 0028277270 scopus 로고
    • Cleavage at the amino-and carboxyl-termini of Alzheimer's amyloid-β by cathepsin D
    • U.S. Ladror, S.W. Snyder, G.T. Wang, T.F. Holzman, G.A. Krafft, Cleavage at the amino-and carboxyl-termini of Alzheimer's amyloid-β by cathepsin D, J. Biol. Chem. 269 (1994) 18422-18428.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18422-18428
    • Ladror, U.S.1    Snyder, S.W.2    Wang, G.T.3    Holzman, T.F.4    Krafft, G.A.5
  • 25
    • 0028113719 scopus 로고
    • Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex
    • L.J. Martin, C.A. Pardo, L.C. Cork, D.L. Price, Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex, Am. J. Pathol. 145 (1994) 1358-1381.
    • (1994) Am. J. Pathol. , vol.145 , pp. 1358-1381
    • Martin, L.J.1    Pardo, C.A.2    Cork, L.C.3    Price, D.L.4
  • 26
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid
    • M. Mullan, F. Crawford, K. Axelman, H. Houlden, L. Lilius, B. Winblad, L. Lannfelt, A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid, Nature Genet. 1 (1992) 345-347.
    • (1992) Nature Genet. , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lilius, L.5    Winblad, B.6    Lannfelt, L.7
  • 27
    • 0029970783 scopus 로고    scopus 로고
    • Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D
    • P. Saftig, C. Peters, K. von Figura, K. Craessaerts, F. Van Leuven, B. De Strooper, Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D, J. Biol. Chem. 271 (1996) 27241-27244.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27241-27244
    • Saftig, P.1    Peters, C.2    Von Figura, K.3    Craessaerts, K.4    Van Leuven, F.5    De Strooper, B.6
  • 31
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants
    • N. Suzuki, T.T. Cheung, X.-D. Cai, A. Odaka, L. Otvos Jr., C. Eckman, T.E. Golde, S.G. Younkin, An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants, Science 264 (1994) 1336-1340.
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.-D.3    Odaka, A.4    Otvos L., Jr.5    Eckman, C.6    Golde, T.E.7    Younkin, S.G.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.