Decreased left frontal lobe N-acetylaspartate in schizophrenia

American Journal of Psychiatry

Volumn 154, Issue 5, 1997, Pages 688-690

  Deicken, Raymond F ^a   Zhou, Ling ^b   Corwin, Faith ^b   Vinogradov, Sophia ^b   Weiner, Michael W ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL LOBE; GLIOSIS; GRAY MATTER; HUMAN; MALE; NERVE CELL LESION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCHIZOPHRENIA; WHITE MATTER;

EID: 0030898266     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.154.5.688     Document Type: Article

References (21)

1. Birken DL, Oldendorf WH: N-Acetyl-1-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 1989; 13:23-31
2. Urenjak J, Williams SR, Gadian DG, Noble M: Proton magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 1993; 13:981-989
3. Guimaraies AR, Carr CA, Schwartz P, Prakash MR, Berger UV, Jenkins BG, Gonzalez RG: Quantitative assessment of neuronal protection using 1H chemical shift imaging (abstract). Proceedings of the Society for Magnetic Resonance 1995; 3:1779
4. Ende G, Knowlton R, Laxer KD, Matson GB, Weiner MW: NAA is a more sensitive marker of hippocampal disease than atrophy: evidence that NAA is a neuronal marker (abstract). Proceedings of the Society for Magnetic Resonance 1996; 3:144
5. Tedeschi G, Bertolino A, Righini A, Campbell G, Raman R, Duyn J, Moonen C, Alger J, DiChiro G: Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. Neurology 1995; 45:1384-1391
6. Bertolino A, Nawroz S, Mattay VS, Duyn JH, Moonen C, Barnett A, Frank J, Tedeschi G, Weinberger DR: A specific anatomical pattern of neuronal impairment in schizophrenia as assessed by multi-slice 1H-MRSI (abstract). Proceedings of the Society for Magnetic Resonance 1995; 3:1844
7. Buckley PF, Moore C, Long H, Larkin C, Thompson P, Mulvany F, Redmond O, Stack JP, Ennis JT, Waddington JL: 1H Magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates. Biol Psychiatry 1994; 36:792-800
8. Bertolino A, Callicott JH, Elman I, Duyn JH, Tedeschi G, Frank JA, Pickar D, Weinberger DR: Proton magnetic resonance spectroscopic imaging in drug-tree patients with schizophrenia: regional neuronal damage (abstract). Biol Psychiatry 1996; 39:634
9. Komoroski R, Heimberg C, Lawson W, Cardwell D, Karson C: A localized in-vivo 1H NMR spectroscopy study of schizophrenics (abstract). Proceedings of the Society for Magnetic Resonance 1995; 3:1846
10. Fukuzako H, Takeuchi K, Hokazono Y, Fukuzako T, Yamada, Hashiguchi T, Obo Y, Ueyama K, Takigawa M, Fujimoto T: Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report. Psychiatry Res: Neuroimaging 1995; 61:193-200
11. Spitzer RL, Williams JBW, Gibbon M, First MB: User's Guide for the Structured Clinical Interview for DSM-III-R (SCID). Washington, DC, American Psychiatric Press, 1990
12. Breier A, Buchanan RW, Elkashef A, Munson RC, Kirkpatrick B, Gellad F: Brain morphology and schizophrenia: a magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Arch Gen Psychiatry 1992; 49:921-926
13. Zipursky RB, Lim KO, Sullivan EV, Brown BW, Pfefferbaum A: Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry 1992; 49:195-205
14. Glantz LA, Lewis DA: Decreased synaptophysin immunoreactivity in prefrontal cortex of schizophrenics (abstract). Biol Psychiatry 1994; 35:717
15. Garey LJ, Patel T, Ong WY: Loss of dendritic spines from cortical pyramidal cells in schizophrenia (abstract). Schizophr Res 1994; 11:137
16. Benes FM, McSparren J, Bird ED, Sangiovanni JP, Vincent SL: Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 1991; 48:996-1001
17. Akbarian S, Bunney WE Jr, Potkin SG, Wigal SB, Hagman JO, Sandman CA, Jones EG: Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch Gen Psychiatry 1993; 50:169-177
18. Akbarian S, Kim JJ, Potkin SG, Hetrick WP, Bunney WE Jr, Jones EG: Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients. Arch Gen Psychiatry 1996; 53:425-436
19. Selemon LD, Rajkowska G, Goldman-Rakic PS: Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17. Arch Gen Psychiatry 1995; 52:805-818
20. Roberts GW, Colter N, Lofthouse R, Bogerts B, Zech M, Crow TJ: Gliosis in schizophrenia: a survey. Biol Psychiatry 1986; 21: 1043-1050
21. Tsai G, Passani LA, Slusher BS, Carter R, Baer L, Kleinman JE, Coyle JT: Abnormal excitatory neu retransmitter metabolism in schizophrenic brains. Arch Gen Psychiatry 1995; 52:829-836