Inhibitory effect of agmatine on proliferation of tumor cells by modulation of polyamine metabolism

Acta Pharmacologica Sinica

Volumn 26, Issue 5, 2005, Pages 616-622

  Wang, Ji Fang ^a   Su, Rui Bin ^a   Wu, Ning ^a   Xu, Bo ^a   Lu, Xin Qiang ^a   Liu, Yin ^a   Li, Jin ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Agmatine; Polyamine; Proliferation; Tumor cell

Indexed keywords

AGMATINE; CYCLOPHOSPHAMIDE; LACTATE DEHYDROGENASE; PUTRESCINE; SPERMIDINE; SPERMINE; THYMIDINE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER MODEL; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; ENZYME RELEASE; HUMAN; HUMAN CELL; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; POLYAMINE METABOLISM; TUMOR CELL;

EID: 18744390816     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Tabor CW, Tabor H. Polyamines. Annu Rev Biochem 1984; 53: 749-90.
2. Seiler N. Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach. Prog Drug Res 1991; 37: 107-59.
3. Raasch W, Regunathan S, Li G, Reis DJ. Agmatine, the bacterial amine, is widely distributed in mammalian tissues. Life Sci 1995; 56: 2310-30.
4. Gabrielson EW, Pegg AE, Casero RA Jr. The induction of spermidine/spermine N1-acetyl transferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new anti-proliferation polyamine analogue N1, N11-bis (ethyl) norspermine. Clin Cancer Res 1999; 5: 1638-41.
5. Satriano J, Kelly CJ, Blantz RC. An emerging role for agmatine. Kidney Int 1999; 56: 1252-3.
6. Vargiu C, Cabella C, Belliardo S, Cravanzola C, Grillo MA, Colombatto S. Agmatine modulates polyamine content in hepatocytes by inducing spermidine/spermine acetyltransferase. Eur J Biochem 1999; 259: 933-8.
7. Cabella C, Gardini G, Corpillo D, Testore G, Bedino S, Solinas SP, et al. Transport and metabolism of agmatine in rat hepatocyte cultures. Eur J Biochem 2001; 268: 940-47.
8. Satriano J, Isome M, Casero RA Jr, Thomson SC, Blantz RC. Polyamine transport system mediates agmatine transport in mammalian cells. Am J Physiol Cell Physiol 2001; 281: C329-34.
9. Gardini G, Cabella C, Cravanzola C, Vargiu C, Belliardo S, Testore G, et al. Agmatine induces apoptosis in rat hepatocyte cultures. J Hepatol 2001; 35: 482-9.
10. Li G, Regunathan S, Barrow CJ, Eshragi J, Cooper R, Reis DJ. Agmatine: an endogenous clonidine displacing substance in the brain. Science 1994; 263: 966-9.
11. Regunathan S, Reis DJ. Stimulation of imidazoline receptors inhibits proliferation of human coronary artery vascular smooth muscle cells. Hypertension 1997; 30: 295-300.
12. Satriano J, Matsufuji S, Murakami Y, Lortie MJ, Schwartz D, Kelly CJ, et al. Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels. J Biol Chem 1998; 273: 15 313-5.
13. Gardini G, Cravanzola C, Autelli R, Testore G, Cesa R, Morando L, et al. Agmatine inhibits the proliferation of rat hepatoma cells by modulation of polyamine metabolism. J Hepatol 2003; 39: 793-9.
14. Ishizuka S, Cunard R, Poucell-Hatton S, Wead L, Lortie M, Thomson SC, et al. Agmatine inhibits cell proliferation and improves renal function in anti-Thy-1 glomerulonephritis. J Am Soc Nephrol 2000; 11: 2256-64.
15. Thomas T, Thomas TJ. Polyamines in cell growth and cell death: molecular mechanism and therapeutic applications. Cell Mol Life Sci 2001; 58: 244-58.
16. Sparapani M, Dall'Olio R, Gandolfi O, Ciani E, Contestabile A. Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells. Exp Neurol 1997; 148: 157-66.
17. Su RB, Wei XL, Liu Y, Li J. Antimalarial effect of agmatine on plasmodium berghei K173 strain. Acta Pharmacol Sin 2003; 24: 918-22.
18. Babal P, Ruchko M, Campbell CC, Gilmour SP, Mitchell JL, Olson JW, et al. Regulation of ornithine decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cells. J Pharmacol Exp Ther 2001; 296: 372-7.
19. D'Agostino L, Di Luccia A. Polyamines interact with DNA as molecular aggregates. Eur J Biochem 2002; 269: 4317-25.
20. Rustenbeck I, Eggers G, Reiter H, Munster W, Lenzen S. Polyamine modulation of mitochondrial calcium transport. Biochem Pharmacol 1998; 56: 977-85.
21. Su RB, Li J, Qin BY. A biphasic opioid function modulator: agmatine. Acta Pharmacol Sin 2003; 24: 631-6.
22. Li YF, Gong ZH, Cao JB, Wang HL, Luo ZP, Li J. Antidepressant-like effect of agmatine and its possible mechanism. Eur J Pharmacol 2003; 469: 81-8.