Agmatine inhibits the proliferation of rat hepatoma cells by modulation of polyamine metabolism

Journal of Hepatology

Volumn 39, Issue 5, 2003, Pages 793-799

  Gardini, Giulia ^a   Cravanzola, Carlo ^a   Autelli, Riccardo ^a   Testore, Giovanni ^a   Cesa, Roberta ^a   Morando, Laura ^a   Solinas, Sandro Paolo ^a   Muzio, Giuliana ^a   Grillo, Maria Angelica ^a   Colombatto, Sebastiano ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Agmatine; Hepatoma cell; Polyamine

Indexed keywords

AGMATINE; ALPHA TUBULIN; ARGININE DECARBOXYLASE; BETA ACTIN; POLYAMINE; PUTRESCINE; SPERMIDINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; POLYAMINE METABOLISM; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

EID: 10744226393     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(03)00386-6     Document Type: Article

References (31)

1. Hahm HA, Dunn VR, Butash KA, Deveraux WL, Woster PM, Casero Jr RA, et al. Combination of Standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines. Clin Cancer Res 2001;7:391-399.
2. Seiler N. Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach. Prog Drug Res 1991;37:107-159.
3. 1-acetyltransferase (SSAT). J Biol Chem 2002;277:3647-3657.
4. 1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. J Biol Chem 2000;275:38319-38328.
5. Casero RA, Woster PM. Terminally activated polyamine analogues as chemotherapeutic agents. J Med Chem 2001;44:1-26.
6. 11-bis(ethyl) norspermine. Clin Cancer Res 1999;5:1638-1641.
7. Vargiu C, Cabella C, Belliardo S, Cravanzola C, Grillo MA, Colombatto S. Agmatine modulates polyamine content in hepatocytes by inducing spermidine/spermine acetyltransferase. Eur J Biochem 1999;259:933-938.
8. Tabor CW, Tabor H. Polyamines. Annu Rev Biochem 1984;53:749-790.
9. Raasch W, Regunathan S, Li G, Reis DJ. Agmatine, the bacterial amine, is widely distributed in mammalian tissues. Life Sci 1995;56:2310-2330.
10. Piletz JE, Chikkala DN, Ernsberger P. Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and α-2 adrenergic receptors. J Pharmacol Exp Ther 1995;272:581-587.
11. Li G, Regunathan S, Barrow CJ, Eshragi J, Cooper R, Reis DJ. Agmatine: an endogenous clonidine displacing substance in the brain. Science 1994;263:966-969.
12. Sener A, Lebrun F, Blaicher F, Malaisse WJ. Stimulus-secretion coupling of arginine-induced insulin release. Insulinotropic action of agmatine. Biochem Pharmacol 1989;38:327-330.
13. Galea E, Regunathan S, Eliopoulos V, Feinstein DL, Reis DJ. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J 1996;316:247-249.
14. Cabella C, Gardini G, Corpillo D, Testore G, Bedino S, Solinas SP, et al. Transport and metabolism of agmatine in rat hepatocyte cultures. Eur J Biochem 2001;268:940-947.
15. Satriano J, Isome M, Casero Jr RA, Thomson SC, Blantz RC. Polyamine transport system mediates agmatine transport in mammalian cells. Am J Physiol Cell Physiol 2001;281:C329-C334.
16. Gardini G, Cabella C, Cravanzola C, Vargiu C, Belliardo S, Testore G, et al. Agmatine induces apoptosis in rat hepatocyte cultures. J Hepatol 2001;35:482-489.
17. Kueng W, Silber E, Eppenberger U. Quantification of cells cultured in 96-well plates. Anal Biochem 1989;182:16-19.
18. Colombatto S, Fasulo L, Fulgosi B, Grillo MA. Transport and metabolism of polyamines in human lymphocytes. Int J Biochem 1990;22:489-492.
19. Grillo MA, Bedino S. Stimulation by insulin of chicken liver ornithine decarboxylase. Int J Biochem 1977;8:711-713.
20. Grillo MA. Acetylation of spermidine in chicken tissues: effect of starvation, insulin, and glucagon. In: Bachrach U, Kaye R, Chayen R, editors. Advances in polyamine research, vol. 4. New York: Raven; 1983. p. 321-330.
21. Lortie MJ, Novotny WF, Peterson OW, Vallon V, Malvey K, Mendonca M, et al. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. J Clin Invest 1996;97:413-420.
22. Lortie MJ, Ishizuka S, Schwartz D, Blantz RC. Bioactive products of arginine in sepsis: tissue and plasma composition after LPS and iNOS blockade. Am J Physiol Cell Physiol 2000;278:C1191-C1199.
23. Ishizuka S, Cunard R, Poucell-Hatton S, Wead L, Lortie M, Thomson SC, et al. Agmatine inhibits cell proliferation and improves renal function in anti-Thy-1 glomerulonephritis. J Am Soc Nephrol 2000;11:2256-2264.
24. Satriano J, Matsufuji S, Murakami Y, Lortie MJ, Schwartz D, Kelly CJ, et al. Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels. J Biol Chem 1998;273:15313-15315.
25. Gleiberman AS, Sharovskaya YuYu, Chailakhjan LM. 'Contact inhibition' of alpha-fetoprotein synthesis and junctional communication in adult mouse hepatocyte culture. Exp Cell Res 1980;184:228-234.
26. Babal P, Ruchko M, Campbell CC, Gilmour SP, Mitchell JL, Olson JW, et al. Regulation of ornithine decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cells. J Pharmacol Exp Ther 2001;296:372-377.
27. Persson L, Lövkvist-Wallström E, Nasizadeh S, Dartsch C, Jeppsson A, Wendt A, et al. Regulation of mammalian ornithine decarboxylase. Biochem Soc Trans 1998;26:575-579.
28. Heby O, Persson L. Molecular genetics of polyamine synthesis in eukaryotic cells. Trends Biochem Sci 1990;15:153-156.
29. Lövkvist-Wallström E, Takao K, Wendt A, Vargiu C, Yin H, Persson L. Importance of the 3′ untranslated region of ornithine decarboxylase mRNA in the translational regulation of the enzyme. Biochem J 2001;356:627-634.
30. Byers TL, Lakanen JR, Coward JK, Pegg AE. The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine. Biochem J 1994;303:363-368.
31. Li L, Li J, Rao JN, Li M, Bass BL, Wang JY. Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis. Am J Physiol 1999;276;C946-C954.