The peptide synthetase gene phsA from Streptomyces viridochromogenes is not juxtaposed with other genes involved in nonribosomal biosynthesis of peptides

Applied and Environmental Microbiology

Volumn 62, Issue 2, 1996, Pages 570-577

  Schwartz, D ^a   Alijah, R ^b   Nussbaumer B ^b   Pelzer, S ^a   Wohlleben, W ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; PEPTIDE SYNTHASE;

ARTICLE; ENZYME ISOLATION; ENZYME STRUCTURE; GENE DISRUPTION; GENETIC COMPLEMENTATION; IMMUNOBLOTTING; PHENOTYPE; SEQUENCE ANALYSIS; STREPTOMYCES;

EID: 0030047124     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/aem.62.2.570-577.1996     Document Type: Article

References (55)

1. Alijah, R., J. Dorendorf, S. Talay, A. Pühler, and W. Wohlleben. 1991 Genetic analysis of the phosphinothricin-tripeptide biosynthetic pathway of Streptomyces viridochromogenes Tü 494. Appl. Microbiol. Biotechnol 34: 749-755.
2. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol Biol. 215:403-410.
3. Anzai, H., T. Murakami, S. Imai, A. Satoh, K. Nagaoka, and C. Thompson. 1987. Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus. J. Bacteriol. 169:3482-3488.
4. Bayer, E., K. H. Gugel, K. Hagele, H. Hagemaier, S. Jassipow, W. A. Konig, and H. Zähner. 1972. Stoffwechselprodukte von Mikroorganismen Phosphinothricin und Phosphinothricyl-Alanyl-Alanin. Helv. Chim. Acta 55:224-239
5. Bibb, M. J., P. R. Findlay, and M. W. Johnson. 1984 The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences. Gene 30: 157-166
6. Bullock, W. O., J. M. Fernandez, and J. M. Short. 1987. XII-Blue a high efficiency plasmid transforming recA Escherichia coli strain with beta galactosidase selection Focus 5:376-378.
7. Chater, K. F., and M. J. Bibb. Regulation of bacterial antibiotic production In H Kleinkauf and H. von Dönren (ed.). Biotechnology, vol. 7. Products of secondary metabolism, in press. VCH, Weinheim, Germany.
8. Cosmina, P., F. Rodriguez, F. de Ferra, G. Grandi, M. Perego, G. Venema, and D. van Sinderen. 1993 Sequence and analysis of the genetic locus, responsible for surfactin synthesis in Bacillus subtilis. Mol. Microbiol 8: 821-831.
9. Dieckmann, R., V.-O. Lee, H. van Liempt, H. von Döhren, and H. Kleinkauf. 1995 Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases. FEBS Lett. 357:212-216
10. Fuma, S., Y. Fujishima, N. Corbell, C. D'Souza, M. M. Nakano, P. Zuber, and K. Yamane. 1993. Nucleotide sequence of 5′ portion of srfA that contains the region required for competence establishment in Bacillus subtilis. Nucleic Acids Res. 21:93-97
11. Gocht, M., and M. A. Marahiel. 1994. Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis. J Bacteriol 176:2654-2662.
12. Gramajo, H. C., J. White, C. R. Hutchinson, and M. J. Bibb. 1991 Over-production and localization of components of the polyketide synthase of Streptomyces glaucescens involved in the production of the antibiotic tetracenomycin C J Bacteriol 173:6475-6483.
13. Hara, O., H. Anzai, S. Imai, Y. Kumada, T. Murakami, R. Itoh, E. Takano, A. Satoh, and K. Nagaoka. 1988 The bialaphos biosynthetic genes of Steptomyces hygroscopicus: cloning and analysis of the genes involved in the alanylation step. J Antibiot 41:538-547.
14. Hara, O., T. Murakami, S. Imai, H. Anzai, K. Itoh, Y. Kumada, E. Takano, E. Satoh, A. Satoh, K. Nagaoka, and C. Thompson. 1991. The bialaphos biosynthesis genes of Streptomyces viridochromogenes: cloning, heterospecific expression, and comparison with genes of Streptomyces hygroscopicus J Gen. Microbiol 137:351-359
15. Harley, C. B., and R. P. Reynolds. 1987. Analysis of E. coli promoter sequences. Nucleic Acids Res. 15:2343-2361
16. Hohn, B., and J. Collins. 1980. A small cosmid for efficient cloning of large DNA fragments Gene 11:291-298.
17. Holt, T. G., C. Chang, C. Laurent-Winter, T. Murakami, J. I. Garrels, J. E. Davies, and C. J. Thompson. 1992. Global changes in gene expression related to antibiotic synthesis in Streptomyces hygroscopicus Mol. Microbiol. 6: 969-980.
18. Hopwood, D. A., M. J. Bibb, K. F. Chater, T. Kieser, C. J. Bruton, H. M. Kieser, D. J. Lydiate, C. P. Smith, J. M. Ward, and H. Schrempf. 1985. Genetic manipulation of Streptomyces: a laboratory manual. John Innes Foundation, Norwich, Conn.
19. Keller, U. Personal communication.
20. Khosla, C., S. Ebert-Khosla, and D. A. Hopwood. 1992 Targeted gene replacement in a Streptomyces polyketide synthase gene cluster. role for the acyl carrier protein Mol. Microbiol. 6:3237-3249.
21. Khosla, C., R. McDaniel, S. Ebert-Khosla, R. Torres, D. H. Sherman, M. J. Bibb, and D. A. Hopwood. 1993. Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins. J Bacteriol. 175:2197-2204.
22. Kondo, Y., T. Shomura, Y. Ogawa, T. Tsuruoka, H. Watanabe, K. Totsukawa, T. Suzuki, C. Moriyama, J. Yoshida, S. Inouye, and T. Niida. 1973. Studies on a new antibiotic SF-1293. I. Isolation and physico-chemical and biological characterization of SF-1293 substances Sci. Rep, Meiji Seika Kaisha 13:34-41
23. Krause, M., and M. A. Marahiel. 1988. Organization of the biosynthesis genes for the peptide antibiotic gramicidin S. J Bacteriol. 170:4669-4674.
24. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685
25. Lawlor, E. J., H. A. Baylis, and K. F. Chater. 1987. Pleiotropic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2). Genes Dev. 1:1305-1310
26. Leskiw, B. K., E. J. Lawlor, J. M. Fernandez-Abalos, and K. F. Chater. 1991. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative Streptomyces mutants. Proc. Natl. Acad. Sci. USA 88:2461-2465.
27. Lipmann, F. 1971. Attempts to map a process evolution of biosynthesis. Science 173:875-884.
28. Marahiel, M. A. 1992. Multidomain enzymes involved in peptide synthesis. FEBS Lett. 307:40-43.
29. Maxam, A. M., and W. Gilbert. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol 65:499-560.
30. Mittenhuber, G., R. Weckermann, and M. A. Marahiel. 1989. Gene cluster containing the genes for tyrocidine synthelases 1 and 2 from Bacillus brevis: evidence for an operon. J. Bacteriol. 171:4881-4887.
31. Muth, G., M. Farr, V. Hartmann, and W. Wohlleben. 1995. Streptomyces ghanaensis plasmid pSG5: nucleotide sequence analysis of the self-transmissible minimal replicon and characterization of the replication mode. Plasmid 33:113-126.
32. Muth, G., B. Nußbaumer, W. Wohlleben, and A. Pühler. 1989. A vector system with temperature-sensitive replication for gene disruption and mutational cloning in streptomycetes. Mol. Gen Genet. 219:341-348.
33. Nußbaumer, B. Unpublished data.
34. Pavela-Vrancic, M., E. Pfeifer, H. van Liempt, H.-J. Schäfer, H. von Döhren, and H. Kleinkauf. 1994. ATP binding in peptide synthetases: determination of contact sites of the adenine moiety by photoaffinity labeling of tyrocidine synthetase 1 with 2-azidoadenosine triphosphate Biochemistry 33:6276-6283
35. Pearson, W. R., and D. J. Lipman. 1988. Improved tools for biological sequence comparison Proc. Natl. Acad Sci. USA 85:2444-2448.
36. Pelzer, S. Personal communication.
37. Pridmore, R. D. 1987. New and versatile cloning-vectors with kanamycin-resistance marker. Gene 56:309-312.
38. Raibaud, A., M. Zalacain, T. G. Holt, R. Tizard, and C. I. Thompson. 1991. Nucleotide sequence analysis reveals linked N-acetyl hydrolase, thioesterase, transport, and regulatory genes encoded by the bialaphos biosynthetic gene cluster of Streptomyces hygroscopicus. J. Bacteriol. 173:4454-4463.
39. Ringquist, S., S. Shinedling, D. Barrick, L. Green, J. Binkley, G. D. Stormo, and L. Gold. 1992 Translation initiation in Escherichia coli sequences within the ribosome-binding site. Mol. Microbiol 6:1210-1229.
40. Rusnak, F., M. Sakaitani, D. Drueckhammer, J. Reichert, and C. T. Walsh. 1991. Biosynthesis of the Escherichia coli siderophore enterobactin, sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine Biochemistry 30:2916-2927.
41. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989 Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor laboratory Press, Cold Spring Harbor, N.Y.
42. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors Proc. Natl. Acad. Sci. USA 74:5463-5467.
43. Saraste, M., P. R. Sibbald, and A. Wittighofer. 1990. The P-loop. A common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci. 15:430-434.
44. Schlumbohm, W., T. Stein, C. Ullrich, J. Vater, M. Krause, M. A. Marahiel, V. Kruft, and B. Wittmann-Liehold. 1991. An active serine is involved in covalent substrate amino acid binding at each reaction center of gramicidin S synthetase. J Biol. Chem. 266:23135-23141.
45. Staden, R., and A. D. McLachlan. 1982. Codon preference and its use in identifying protein coding regions in large DNA sequences. Nucleic Acids Res. 10:141-156
46. Strauch, E., W. Wohlleben, and A. Pühler. 1987. Development of a plasmid-cloning system for Streptomyces viridochromogenes Tu494. J. Basic Microbiol. 27:449-155.
47. Strauch, E., W. Wohlleben, and A. Pühler. 1988. Cloning of phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Streptomyces lividans and Escherichia coli Gene 63:65-74.
48. Strohl, W. R. 1992. Compilation and analysis of DNA sequences associated with apparent Streptomyces promoters Nucleic Acids Res. 20:961-974.
49. Tokita, K., K. Hori, T. Kurotsu, M. Kanda, and Y. Seto. 1993. Effect of single base substitutions at glycine-870 codon of gramicidin S synthetase gene on proline activation. J. Biochem 114:522-527.
50. Turgay, K., M. Krause, and M. A. Marahiel. 1992. Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes. Mol. Microbiol 6:529-546
51. Vasil, V., A. M. Castillo, M. E. Fromm, and I. K. Vasil. 1992. Herbicide resistant fertile transgenic wheat plants obtained by microprojectile bombardment of regenerable embryogenic callus. Bio/Technology 10:667-074.
52. Vieira, J., and J. Messing. 1982. The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers Gene 19:259-268.
53. von Döhren, H., E. Pfeifer, H. van Liempt, Y.-O. Lee, M. Pavela-Vrancic, and T. Schwecke. 1993. The nonribosomal system: what we learn from the genes encoding protein templates, p. 159-167 In R H. Baltz, G. D. Hegeman, and P. L Skatrud (ed.), Industrial microorganisms: basic and applied molecular genetics. American Society for Microbiology, Washington, D C.
54. Wohlleben, W., W. Arnold, I. Broer, D. Hillemann, E. Strauch, and A. Pühler. 1988. Nucleotide sequence of the phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes and its expression in Nicotiana tabacum. Gene 70:25-37.
55. Wohlleben, W., R. Alijah, J. Dorendorf, D. Hillemann, B. Nußbaumer, and S. Pelzer. 1992 Identification and characterization of phosphinothricin-tripeptide biosynthetic genes in Streptomyces viridochromogenes. Gene 115:127-132.