Correlation between CD4, CD8 cell infiltration in gastric mucosa, Helicobacter pylori infection and symptoms in patients with chronic gastritis

World Journal of Gastroenterology

Volumn 11, Issue 16, 2005, Pages 2486-2490

  Lu, Ai Ping ^a,e   Zhang, Sheng Sheng ^c   Zha, Qing Lin ^b   Ju, Da Hong ^a   Wu, Hao ^a   Jia, Hong Wei ^a   Xiao, Cheng ^a   Li, Shao ^d   Jian, Hui ^e  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b Jiangxi Traditional Chinese Medicine Institute   (China)

^c BEIJING HOSPITAL OF TRADITIONAL CHINESE MEDICINE AFFILIATED TO CAPITAL MEDICAL UNIVERSITY   (China)

^d TSINGHUA UNIVERSITY   (China)

^e National Pharmaceutical Engineer Center for Herbal Solid Preparation   (China)

Author keywords

Chronic gastritis; Helicobacter pylori infection; Mucosal immune; Symptoms

Indexed keywords

ADULT; AGED; ARTICLE; CHRONIC GASTRITIS; CLUSTER ANALYSIS; COLD LIMB; CORRELATION ANALYSIS; DIGESTION; FEMALE; FROZEN SECTION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOGISTIC REGRESSION ANALYSIS; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; STOMACH ANTRUM; STOMACH BIOPSY; STOMACH MUCOSA; SYMPTOMATOLOGY; THIRST;

EID: 18744365800     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i16.2486     Document Type: Article

References (12)

1. Aguilar GR, Ayala G, Fierros-Zarate G. Helicobacter pylori: recent advances in the study of its pathogenicity and prevention. Salud Publica Mex 2001; 43: 237-247
2. Prinz C, Schoniger M, Rad R, Becker I, Keiditsch E, Wagenpfeil S, Classen M, Rosch T, Schepp W, Gerhard M. Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation. Cancer Res 2001; 61: 1903-1909
3. Ohara T, Arakawa T, Higuchi K, Kaneda K. Overexpression of co-stimulatory molecules in peripheral mononuclear cells of Helicobacter pylori-positive peptic ulcer patients: possible difference in host responsiveness compared with non-ulcer patients. Eur J Gastroenterol Hepatol 2001; 13: 11-18
4. Peterson RA 2nd, Hoepf T, Eaton KA. Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritis. Comp Med 2003; 53: 498-509
5. Riedel S, Kraft M, Kucharzik T, Pauels HG, Tiemann M, Steinbuchel A, Domschke W, Lugering N. CD4+ Th1-cells predominate in low-grade B-cell lymphoma of gastric mucosa-associated lymphoid tissue (MALT type). Scand J Gastroenterol 2001; 36: 1198-1203
6. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated sydney system. International workshop on the histopathology of gastritis, houston 1994. Am J Surg Pathol 1996; 20: 1161-1181
7. Sommer F, Faller G, Konturek P, Kirchner T, Hahn EG, Zeus J, Rollinghoff M, Lohoff M. Antrum- and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype. Infect Immunol 1998; 66: 5543-5546
8. Suzuki T, Ito M, Hayasaki N, Ishihara A, Ando T, Ina K, Kusugami K. Cytotoxic molecules expressed by intraepithelial lymphocytes may be involved in the pathogenesis of acute gastric mucosal lesions. J Gastroenterol 2003; 38: 216-221
9. Nakagawa K, Higuchi K, Arakawa T, Kobayashi K, Kaneda K. Phenotypical and morphological analyses of intraepithelial and lamina propria lymphocytes in normal and regenerating gastric mucosa of rats in comparison with those in intestinal mucosa. Arch Histol Cytol 2000; 63: 159-167
10. De Silva HD, Van Driel IR, La Gruta N, Toh BH, Gleeson PA. CD4+ T cells, but not CD8+ T cells, are required for the development of experimental autoimmune gastritis. Immunology 1998; 93: 405-408
11. Yuceyar H, Saruc M, Kokuludag A, Terzioglu E, Goksel G, Isisag A. The systemic cellular immune response in the Helicobacter pylori-associated duodenal ulcer and chronic antral gastritis. Hepatogastroenterology 2002; 49: 1177-1179
12. Itoh T, Wakatsuki Y, Yoshida M, Usui T, Matsunaga Y, Kaneko S, Chiba T, Kita T. The vast majority of gastric T cells are polarized to produce T helper 1 type cytokines upon antigenic stimulation despite the absence of Helicobacter pylori infection. J Gastroenterol 1999; 34: 560-570