Pulmonary vascular dilation induced by L-ARGININE: Correlation with induction of endothelial nitric oxide synthase in a rabbit model

Acta Radiologica

Volumn 46, Issue 1, 2005, Pages 48-54

  Yoon, S K ^a   Lee, K N ^a,b   Lee, J H ^a   Jeong, J S ^a   Kwak, J Y ^a  

^a Dong A University   (South Korea)

^b Dong A University College of Medicine   (South Korea)

Author keywords

CT; L ARGININE; Nitric oxide synthase; Pulmonary arteries

Indexed keywords

BIOLOGICAL ORGANS; COMPUTERIZED TOMOGRAPHY; ENZYMES; HISTOLOGY; LIVING SYSTEMS STUDIES; NITROGEN COMPOUNDS; TISSUE;

L-ARGININE; NITRIC OXIDE SYNTHASE; PULMONARY ARTERIES;

PULMONARY DISEASES;

ARGININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NITRITE;

ANIMAL; ANIMAL MODEL; ARTICLE; BLOOD; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFECT; ENZYMOLOGY; FEMALE; LUNG; METABOLISM; ORAL DRUG ADMINISTRATION; PULMONARY ARTERY; RABBIT; RADIOGRAPHY; VASODILATATION;

ADMINISTRATION, ORAL; ANIMALS; ARGININE; FEMALE; LUNG; MODELS, ANIMAL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; PULMONARY ARTERY; RABBITS; TOMOGRAPHY, X-RAY COMPUTED; VASODILATION;

EID: 18744364429     PISSN: 02841851     EISSN: 16000455     Source Type: Journal    
DOI: 10.1080/02841850510012607     Document Type: Article

References (32)

1. Adams MR, McCredie R, Jessup W, Robinson J, Sullivan D, Celermajer DS. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis 1997;129:261-9.
2. Bode-Böger SM, Böger RH, Alfke H, Heinzel D, Tsikas D, Creutzig A, et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 1996;93:85-90.
3. Bogle RG, Baydoun AR, Pearson JD, Moncada S, Mann GE. L-arginine transport is increased in macrophages generating nitric oxide. Biochem J 1992;284:15-18.
4. Bosmans JM, Vrints CJ, Kockx MM, Bult H, Cromheeke KM, Herman AG. Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation. Arterioscler Thromb Vasc Biol 1999;19: 767-76.
5. Cohen GA, Hobbs AJ, Fitch RM, Zinner MJ, Chaudhuri G, Ignarro LJ. Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo. Am J Physiol 1996;271:133-9.
6. Egashira K, Hirooka Y, Kuga T, Mohri M, Takeshita A. Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. Circulation 1996;94:130-4.
7. Fallon MB, Abrams GA, Luo B, Hou Z, Dai Z, Ku DD. The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome. Gastroenterology 1997;113:606-14.
8. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
9. Hamon M, Vallet B, Bauters C, Wernert N, McFadden EP, Lablanche JM, et al. Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury. Circulation 1994;90:1357-62.
10. Huk I, Nanobashvili J, Neumayer C, Punz A, Mueller M, Afkhampour K, et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation 1997;96:667-75.
11. Ignarro LJ. Endothelium-derived nitric oxide: pharmacology and relationship to the actions of organic nitrate esters. Pharm Res 1992;6:651-9.
12. Ignarro LJ, Buga GM, Wood KS, Byrns R, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84:9265-9.
13. Jeremy RW, McCarron H, Sullivan D. Effects of dietary L-arginine on atherosclerosis and endothelium-dependent vasodilatation in the hypercholesterolemic rabbit. Response according to treatment duration, anatomic site, and sex. Circulation 1996;94:498-506.
14. Kalinowski M, Alfke H, Bergen S, Klose KJ, Barry JJ, Wagner HJ. Comparative trial of local pharmacotheraphy with L-arginine, r-hirudin, and molsidomine to reduce restenosis after balloon angioplasty of stenotic rabbit iliac arteries. Radiology 2001;219:716-23.
15. Katayose D, Ohe M, Yamauchi K, Ogata M, Shirato K, Fujita H, et al. Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension. Am J Physiol 1993;264:L100-6.
16. Kelm M, Schrader J. Nitric oxide release from the isolated guinea pig heart. Eur J Pharmacol 1988;155: 317-21.
17. Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, et al. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 1993;9:371-7.
18. Kourembanas S, McQuillan LP, Leung GK, Faller DV. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest 1993;92:99-104.
19. Kuriyama K, Gamsu G, Stern RG, Cann C, Herfken RJ, Brundage BH. CT-determined pulmonary artery diameters in predicting pulmonary hypertension. Invest Radiol 1984;19:16-22.
20. Lee KN, Jung WJ, Yoon SK, Nam KJ, Kwak JY, Son CH, et al. Correlation of pulmonary vascular dilatation on HRCT to expression of eNOS in a rabbit model of hepatopulmonary syndrome. J Korean Radiol Soc 2001;44:475-83.
21. Lonn EM, Yusuf S, Jha P, Montague TJ, Teo KK, Benedict CR, et al. Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection. Circulation 1994;90:2056-69.
22. Marletta MA. Nitric oxide synthase structure and mechanism. J Biol Chem 1993;268:12231-4.
23. Michelakis ED. The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension. Heart Fail Rev 2003;8:5-21.
24. Mitani Y, Maruyama K, Sakurai M. Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation 1997;96:689-97.
25. Moncada S, Higgs EA. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-12.
26. Nagaya N, Uematsu M, Oya H, Sato N, Sakamaki F, Kyotani S, et al. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir Crit Care Med 2001;163:887-91.
27. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelium cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-6.
28. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release account for the biologic activity of endothelium-derived relaxing factor. Nature 1987;327:524-6.
29. Reyes AA, Karl IE, Klahr S. Role of arginine in health and disease. Am J Physiol 1994;267:F331-46.
30. Sanson AJ, Malangoni MA. Hypoxic increases nitric oxide concentrations that are not completely inhibited by L-NMMA. J Surg Res 2003;110:202-6.
31. Shimokawa H, Lam JY, Chesebro JH, Bowie EJ, Vanhoutte PM. Effects of dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries. Circulation 1987;76:898-905.
32. Williams JK, Adams MR, Herrington DM, Clarkson TB. Short-term administration of estrogen and vascular responses of atherosclerotic coronary arteries. J Am Coll Cardiol 1992;20:452-7.