Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 3, 1999, Pages 767-776

  Bosmans, Johan M ^a,c   Vrints, Chris J ^a   Kockx, Mark M ^b   Bult, Hidde ^a   Cromheeke, Kristel M C ^a   Herman, Arnold G ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b MIDDELHEIM HOSPITAL   (Belgium)

^c ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Balloon dilatation; L arginine; Neointima; Nitric oxide; Remodeling; Restenosis

Indexed keywords

ARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DILATATION; ARTERY INTIMA PROLIFERATION; ARTICLE; BALLOON DILATATION; CAROTID ARTERY; CONTROLLED STUDY; HISTOLOGY; MALE; MORPHOMETRICS; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RABBIT;

EID: 0032975499     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.3.767     Document Type: Article

References (53)

1. Serruys PW, Luijten HE, Beatt KJ, Geuskens R, de Feyter PJ, van den Brand M, Reiber JHC, ten Katen F, van Es GA, Hugenholtz PG. Incidence of restenosis after successful angioplasty: a time-related phenomenon; A quantitative angiographic study in 324 consecutive patients at 1,2,3 and 4 months. Circulation. 1988;77:361-371.
2. Nobuyoshi M, Kimura T, Nosaka H, Mioka S, Ueno K, Yokoi H, Hamsaki N, Horiuchi H, Ohishi H. Restenosis after successful percutaneous transluminal coronary angioplasty: Serial angiographic follow-up of 229 patients. J Am Coll Cardiol. 1988;12:616-623.
3. Brieger D, Topol E. Local drug delivery systems and prevention of restenosis. Cardiovasc Res. 1997;35:405-413.
4. Liu MW, Roubin GS, King SBI. Restenosis after coronary angioplasty: potential biological determinants and role of intimal hyperplasia. Circulation. 1989;79:1374-1387.
5. Ip JH, Fuster V, Badimon L, Badimon J, Taubman MB, Chesebro JH. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. J Am Coll Cardiol. 1990;15:1667-1687.
6. Forrester JS, Fishbein M, Helfant R, Fagin J. A paradigm for restenosis based on cell biology: clues for the development of new preventive therapies. J Am Coll Cardiol. 1991;17:758-769.
7. Glagov S. Intimal hyperplasia, vascular modeling, and the restenosis problem. Circulation. 1994;89:2888-2891.
8. Currier JW, Faxon DP. Restenosis after percutaneous transluminal coronary angioplasty: have we been aiming at the wrong target? J Am Coll Cardiol 1995;25:516-520.
9. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371-1375.
10. Hermiller JB, Tenaglia AN, Kisslo KB, Phillips HR, Bashore TM, Stack RS, Davidson CJ. In vivo validation of compensatory enlargement of atherosclerotic coronary arteries. Am J Cardiol. 1993;71:665-668.
11. Kovach JA, Mintz GS, Kent KM, Pichard AD, Satler LF, Popma JJ, Leon MB. Serial intravascular ultrasound studies indicates that chronic recoil is an important mechanism of restenosis following transcatheter therapy. J Am Coll Cardiol. 1993;21:484A (Abstract).
12. Mintz GS, Pichard AD, Kent KM, Satler LF, Leon MB. Intravascular ultrasound comparison of restenotic and de novo coronary artery narrowings. Am J Cardiol. 1994;74:1278-1280.
13. Ge J, Erbel R, Zamorano J, Koch L, Kearney P, Gorge G, Gerber T, Meyer J. Coronary artery remodeling in atherosclerotic disease: an intravascular ultrasonic study in vivo. Coron Artery Dis. 1993;4(11):981-986.
14. Kerber RE, Armstrong ML, Kieso RA, Smith RS, Tompkins PK. Compensatory enlargement (remodeling) of atherosclerotic arteries is time-dependent in rabbits. Circulation. 1993;88:2808 (Abstract).
15. Kakuta T, Currier JW, Haudenschild CC, Ryan TJ, Faxon DP. Differences in compensatory vessel enlargement, not intimal formation, account for restenosis after angioplasty in the hypercholesterolemic rabbit model. Circulation. 1994;89:2809-2815.
16. Gertz SD, Gimple LW, Banai S, Ragosta M, Powers ER, Roberts WC, Perez LS, Sarembock IJ. Geometric remodeling is not the principal pathogenetic process in restenosis after balloon angioplasty. Evidence from correlative angiographic-histomorphometric studies of atherosclerotic arteries in rabbits. Circulation. 1994;90:3001-3008.
17. Post M, Borst C, Kuntz RE. The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty: a study in the normal rabbit and the hypercholesterolemic Yucatan micropig. Circulation. 1994;89:2816-2821.
18. Lafont A, Guzman LA, Whitlow PL, Goormastic M, Cornhill JF, Chisolm GM. Restenosis after experimental angioplasty. Intimal, medial, and adventitial changes associated with constrictive remodeling. Circ Res. 1995;76:996-1002.
19. Wilensky RL, March KL, Gradus-Pizlo I, Sandusky G, Fineberg N, Hathaway DR. Vascular injury, repair, and restenosis after percutaneous transluminal angioplasty in the atherosclerotic rabbit. Circulation. 1995; 92:2995-3005.
20. Moncada S, Higgs A. Mechanisms of disease: the L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2013.
21. Cooke JP, Tsao PS. Is NO an endogenous antiatherogenic molecule? Arterioscler Thromb. 1994;14:653-655.
22. Bult H, Fret HRL, Van den Bossche RM, Herman AG. Platelet inhibition by endothelium-derived relaxing factor from the rabbit perfused aorta. Br J Pharmacol. 1988;95:1308-1314.
23. Schini VB, Vanhoutte PM. Role of the L-arginine-nitric oxide pathway in vascular smooth muscle. Eur Heart J. 1993;14:16-22.
24. Scott-Burden T, Vanhoutte PM. The endothelium as a regulator of vascular smooth muscle proliferation. Circulation. 1993:87(suppl V):V51-V56.
25. Graf H. Endothelial control of cell migration and proliferation. Eur Heart J. 1993;14:183-187.
26. Bosmans JM, Bult H, Vrints CJM, Kockx M, Claeys M, Snoeck JP, Herman AG. Balloon angioplasty leads to induction of vascular nitric oxide synthase. In: Moncada S, Feelisch M, Busse R, Higgs EA, eds. The Biology of Nitric Oxide. Physiological and Clinical Aspects. London, UK: Portland Press Ltd; 1994.
27. Bosmans JM, Bult H, Vrints CJ, Kockx M, Herman AG. Balloon angioplasty and induction of non-endothelial nitric oxide synthase in rabbit carotid arteries. Eur J Pharmacol. 1996;310:163-174.
28. Joly GA, Schini VB, Vanhoutte PM. Balloon injury and interleukin - 1 beta induce nitric oxide synthase activity in rat carotid arteries. Circ Res. 1992;71:331-338.
29. Cromheeke KM, Kockx MM, Bosmans JM, Bult H, Vrints CJ, Herman AG. Presence of inducible nitric oxide synthase in ceroid containing macrophages in human atherosclerotic plaques. Circulation. 1997; 96(8):I-234 (Abstract).
30. Cromheeke KM, Bosmans JM, Bult H, Vrints CJ, Herman AG, Kockx MM. Detection of inducible nitric oxide synthase is related to thrombus organisation in rabbit carotid arteries and in advanced human atherosclerotic plaques. Acta Cardiol. 1997;6:540 (Abstract).
31. McNamara DB, Bedi B, Aurora H, Tena L, Ignarro LJ, Kadowitz PJ, Akers DL. L-Arginine inhibits balloon catheter-induced intimal hyperplasia. Biochem Biophys Res Commun. 1993;1:291-296.
32. McNamara DB. L-Arginine inhibits neointimal formation following balloon injury. Life Sci. 1994;54:283-284.
33. Tarry WC, Makhoul RG. L-Arginine improves endothelium-dependent vasorelaxation and reduces intimal hyperplasia after balloon angioplasty. Arterioscler Thromb Vasc Biol. 1994;14:938-943.
34. Bosmans JM, Kockx MM, Vrints CJ, Bult H, De Meyer GRY, Herman AG. Fibrin(ogen) and von Willebrand factor deposition are associated with intimai thickening after balloon angioplasty of the rabbit carotid artery. Arterioscler Thromb Vasc Biol. 1997;17:634-645.
35. Kockx MM, De Meyer GRY, Andries LJ, Bult H, Jacob WA, Herman AG. The endothelium during cuff-induced neointima formation in the rabbit carotid artery. Arterioscler Thromb Vasc Biol. 1993;13: 1874-1884.
36. Bult H, De Meyer GRY, Herman AG. Influence of chronic treatment with a nitric oxide donor on fatty streak development and reactivity of the rabbit aorta. Br J Pharmacol. 1995;114:1371-1382.
37. De Meyer GR, Bult H, Van Hoydonck A, Jordaens FH, Buyssens N, Herman AG. Neointima formation impairs endothelial muscarinic receptors while enhancing prostacyclin mediated responses in the rabbit carotid artery. Circ Res. 1991;68:1669-1680.
38. Weidinger FF, McLenacham JM, Cybulsky MI, Gordon JB, Rennke HG, Hollenberg NK. Persistent dysfunction of regenerated endothelium after balloonangioplasty of rabbit iliac artery. Circulation. 1990;81: 1667-1679.
39. Cooke JP, Andon NA, Girerd XJ, Hirsch AT, Creager MA. Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation. 1991;83:1057-1062.
40. Rossitch E, Alexander E III, Black PM, Cooke JP. L-Arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. J Clin Invest. 1991;87:1295-1299.
41. Girerd XJ, Hirsch AT, Cooke JP, Dzau VJ, Creager MA. L-Arginine augments endothelium-dependent vasodilatation in cholesterol-fed rabbits. J Clin Invest. 1991;90:1248-1253.
42. Dubey RK, Jackson EK, Lüscher TF. Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. J Clin Invest. 1995;96:141-149.
43. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83: 1774-1777.
44. Albina JE, Cui S, Mateo RB, Reichner JS. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol. 1993;150: 5080-5085.
45. Key K, Becker MHG, Baron B, Duchrow M, Schlüter C, Flad HD, Gerdes J. New Ki 67 murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki 67 cDNA containing three 62 base pair repetitive elements for the Ki 67 epitope. Lab Invest. 1993;68: 629-636.
46. McCormick D, Yu C, Hobbs C. The relevance of antibody concentration to the immunohistological quantification of cell proliferation associated antigens. Histopathology. 1993;22:543-547.
47. Groves PH, Banning AP, Penny WJ, Lewis MJ, Cheadle HA, Newby AC. Kinetics of smooth muscle cell proliferation and intimal thickening in a pig carotid model of balloon injury. Atherosclerosis. 1995;117:83-96.
48. Peunova N, Enikolopov G. Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells. Nature. 1995;375:68-73.
49. Singer AH, Tsao PS, Wang B-Y, Bloch DA, Cooke JP. Discordant effects of dietary L-arginine on vascular structure and reactivity in hypercholes-terolemic rabbits. J Cardiovasc Pharmacol. 1995;25:710-716.
50. Cayatte AJ, Palacino JJ, Horten K, Cohen RA. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol. 1994;14:753-759.
51. Barbul A. Physiology and pharmacology of arginine. In: Moncada S, Higgs EA, eds. Nitric Oxide from L-Arginine: A Bioregulatory System. Amsterdam, the Netherlands: Elsevier Science Publishers; 1990:317-329.
52. Gross SS, Stuehr DJ, Aisaka K, Jaffe EA, Levi R, Griffith OW. Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochem Biophys Res Commun. 1990;170:96-103.
53. Taguchi J, Abe J, Okazaki H, Takuwa Y, Kurokawa K. L-arginine inhibits neointimal formation following balloon injury. Life Sci. 1993;53: 387-392.