Physiopathological determinants of human infertility

Human Reproduction Update

Volumn 8, Issue 5, 2002, Pages 435-447

  Baird, D T ^a   Benagiano, G ^b   Cohen, J ^b   Collins, J ^b   Evers, L H ^b   Fraser, L ^c   Jacobs, H ^c   Liebaers, I ^b   Tarlatzis, B ^b   Templeton, A ^d   Van Steirteghem, A ^b   Crosignani, P G ^b   Diczfalusy, E ^b   Diedrich, K ^b   Frigerio, G C ^b   Gianaroli, L ^b   Glasier, A ^a   Persson, J ^b   Quartarolo, J P ^b   Ragni, G ^b  

^a Edinburgh   (United Kingdom)

^b NONE   (Italy)

^c London Center   (United Kingdom)

^d Aberdeen   (United Kingdom)

Author keywords

Anovulation; Assisted procreation; Genetic abnormalities; Infertility; Sexually transmitted disease

Indexed keywords

ANTIESTROGEN; CLOMIFENE; GONADOTROPIN; INSULIN; MESTEROLONE; METFORMIN; PIOGLITAZONE; ROSIGLITAZONE; TESTOSTERONE ENANTATE; TROGLITAZONE;

ADULT; AGING; AMENORRHEA; AUTOIMMUNITY; CONTROLLED STUDY; DIAGNOSTIC TEST; DIATHERMY; DISEASE DURATION; DRUG MECHANISM; ENDOCRINE DISEASE; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; GENETIC DISORDER; HIRSUTISM; HUMAN; HYPERANDROGENISM; LEIOMYOMA; MALE; MALE INFERTILITY; MORBIDITY; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PREGNANCY DISORDER; PRIORITY JOURNAL; PROGENY; PROGNOSIS; REVIEW; SEXUAL TRANSMISSION; SYMPTOMATOLOGY; UTERUS BLEEDING; UTERUS DISEASE;

AGING; AUTOIMMUNE DISEASES; ENDOCRINE GLANDS; FEMALE; HUMANS; HYPERANDROGENISM; INFERTILITY; INFERTILITY, FEMALE; INFERTILITY, MALE; MALE; REPRODUCTION; SEXUALLY TRANSMITTED DISEASES; UTERUS;

EID: 18644385471     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/8.5.435     Document Type: Review

References (114)

1. Baird, D.T. (1997) Amenorrhoea. Lancet, 350, 275-279.
2. Baird, D.T. (2001) Amenorrhoea, anovulation and dysfunctional uterine bleeding. In de Grout, L.J. and Jameson, J.L. (eds), Endocrinology, 4th edition. W.B.Saunders, Philadelphia, Chapter 157.
3. Bajeral, N. and Li, T.C. (2000) Fibroids: infertility and pregnancy wastage. Hum. Reprod Update, 6, 614-620.
4. Berkowitz, G.S., Skovron, M.L., Lapinski, R.H. and Berkowitz, R.L. (1990) Delayed childbearing and the outcome of pregnancy. N. Engl. J. Med., 322, 659-664.
5. Bischoff, F.Z. and Simpson, J.L. (2000) Heritability and molecular genetic studies of endometriosis. Hum. Reprod Update, 6, 37-44.
6. Bogan, J.S. and Page, D.C. (1994) Testis? - A mammalian dilemma. Cell, 76, 603-607.
7. Buchter, D., Behre, H.M., Kliesch, S. and Nieschlag, E. (1998) Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotrophin as effective treatment for men with hypogonatropic hypogonadism: a review of 42 cases. Eur. J. Endocrinol., 139, 298-330.
8. Campbell, I.G. and Thomas, E.J. (2001) Endometriosis: candidate genes. Hum. Reprod Update, 7, 15-20.
9. Chilcott, I.T., Margara, R., Cohen, H., Rai, R., Skull, J., Pickering, W. and Regan, L. (2000) Pregnancy outcome is not affected by antiphospholipid antibody status in women referred for in vitro fertilization. Fertil. Steril., 73, 526-530.
10. Clark, A.M., Ledger, W., Galletly, C., Tomlinson, L., Blaney, F., Wang, X. and Norman, R.J. (1995) Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum. Reprod., 10, 2705-2712.
11. Collins, J.A., Burrows, E.A. and Willan, A.R. (1995). The prognosis for live birth among untreated infertile couples. Fertil. Steril., 64, 22-28.
12. Comhaire, F.H., de Kretser, D.M., Farley, T.M. and Rowe, P.J. (1987) Towards more objectivity in diagnosis and treatment of male infertility. Int. J. Androl., 7 (suppl.), 1-53.
13. Conway, G.S. (2000) Premature ovarian failure. Br. Med. Bull., 56, 643-649.
14. Conway, G.S. and Jacobs, H.S. (1993) Clinical implications of hyperinsulinaemia in women. Clin. Endocrinol., 39, 623-632.
15. Coulam, C.B., Krysa, L., Stern, J.J. and Bustillo, M. (1995) Intravenous immunoglobulin for treatment of recurrent pregnancy loss. Am. J. Reprod. Immunol., 34, 333-337.
16. Cuppens, H., Lin, W. and Jaspers, M. (1998) Polyvariant mutant cystic fibrosis conductance regulator genes. The polymorphic (TG)m locus explains the partial penetrance of the T5 polymorphism as a disease mutation. J. Clin. Invest., 101, 487-496.
17. de Kretser, D.M. and Baker, H.N.G. (1995) Human infertility: the male factor. In Adashi, E.Y., Rock, J.A. and Rosenwaks, Z. (eds), Reproductive Endocrinology, Surgery and Technology. Volume 2. Lippincott Raven, Philadelphia, pp. 2031-2061.
18. Donnez, J. and Nisole, M. (1997) Endoscopic laser treatment of uterine malformations. Hum. Reprod., 12, 1381-1388.
19. Dunaif, A. (1997) Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev., 18, 774-800.
20. Eaton, J.W. and Mayer, A.J. (1953) The social biology of very high fertility among the hutterites. The demography of a unique population. Hum. Biol., 25, 206-264.
21. Eimers, J., te Velde, E.R., Gerritse, R., Vogelzang, E.T., Looman, C.W.N. and Habbema, J.D.F. (1994). The prediction of the chance to conceive in subfertile couples. Fertil. Steril., 61, 44-52.
22. Emanuel, M.H., Wamsteker, K., Hart, A.A., Metz, G. and Lammes, F.B. (1999) Long-term results of hysteroscopic myomectomy for abnormal uterine bleeding. Obstet. Gynecol., 93, 743-748.
23. Erickson, J.D. (1978) Down's syndrome, paternal age, maternal age and birth order. Ann. Hum. Genet., 41, 289-293.
24. Eschenbach, D.A., Wolner-Hanssen, P., Hawes, S.E., Pavletic, A., Paavonen, J. and Holmes, K.K. (1997) Acute pelvic inflammatory disease: associations of clinical and laboratory findings with laparoscopic findings. Obstet. Gynecol., 89, 184-189.
25. FeÌdeÌration CECOS, Schwartz, D. and Mayaux, M.J. (1982) Female fecundity as a function of age: results of artificial insemination in 2193 nulliparous women with azoospermic husbands. N. Engl. J. Med., 306, 404-406.
26. Filicori, M., Cognini, G.E., Pocognoli, P., Cantelli, B., Ferlini, F., Marconi, R. and Parmegiani, L. (2001) Gonadotrophin ovulation induction in hypogonadotrophic hypogonadism. In Filicori, M. (ed.), Ovulation Induction: Third World Congress. CIC Edizioni Internazionali, Rome, pp. 99-106.
27. Fonteyn, V.J. and Isada, N.B. (1988) Nongenetic implications of childbearing after age thirty-five. Obstet. Gynecol. Surv., 43, 709-720.
28. Franks, S. (1995) Polycystic ovary syndrome. N. Engl. J. Med., 333, 853-861.
29. Fu, Y.H., Kuhl, D.P., Pizzuti, A., Pieretti, M., Sutcliffe, J.S., Richards, S., Verkerk, A.J., Holden, J.J., Fenwick, R.G., Jr, Warren, S.T. et al. (1991) Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell, 67, 1047-1058.
30. Glueck, C.J., Phillips, H., Cameron, D., Sieve-Smith, L. and Wang, P. (2001) Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study. Fertil. Steril., 75, 46-52.
31. Goldenberg, M., Sivan, E., Sharabi, Z., Maschiach, S., Lipitz, S. and Seidman, D.S. (1995) Reproductive outcome following hysteroscopic management of intrauterine septum. Hum. Reprod, 10, 2663-2665.
32. Gottlieb, B., Beitel, L.K., Lumbroso, R., Pinsky, L. and Trifiro, M. (1999) Update of the androgen receptor gene mutations database. Hum. Mut., 14, 103-114.
33. Govind, A., Obhrai, M.S. and Clayton, R.N. (1999) Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families. J. Clin. Endocrinol. Metab., 84, 38-43.
34. Gray, R.H. (1990) Epidemiology of infertility. Curr. Opin. Obstet. Gynecol., 2, 154.
35. Grimbizis, G., Vandervorst, M., Camus, M., Tournaye, H., Van Steirteghem, A. and Devroey, P. (1998a) Intracytoplasmic sperm injection, results in women older than 39, according to age and the number of embryos replaced in selective or non-selective transfers. Hum. Reprod., 13, 884-889.
36. Grimbizis, G., Camus, M., Clasen, K., Tournaye, H., De Munck, L. and Devroey, P. (1998b) Hysteroscopic septum resection in patients with recurrent abortions or infertility. Hum. Reprod., 13, 1188-1193.
37. Grimbizis, G.F., Camus, M., Tarlatzis, B.C., Bontis, J.N. and Devroey, P. (2001) Clinical implications of uterine malformations and hysteroscopic treatment results. Hum. Reprod. Update, 7, 161-174.
38. Hager, W.D., Eschenbach, D.A., Spence, M.R. and Sweet, R.L. (1983) Criteria for diagnosis and grading of salpingitis. Obstet. Gynecol., 61, 113-117.
39. Hague, W.M., Adams, J., Rodda, C., Brook, C.G., de Bruyn, R., Grant, D.B. and Jacobs, H.S. (1990) The prevalence of polycystic ovaries in patients with congenital adrenal hyperplasia and their close relatives. Clin. Endocrinol., 33, 501-510
40. Hamou, J.E. (1998) Hysteroscopy for reproductive surgery in the female. In: Kempers, R.D., Cohen, J., Haney, A.F. and Younger, J.B. (eds), Fertility and Reproductive Medicine. Elsevier Science, Amsterdam, pp. 343-347.
41. Hansen, J.P. (1986) Older maternal age and pregnancy outcome: a review of the literature. Obstet. Gynecol. Surv., 41, 726-733.
42. Henry, L. (1961) Some data on natural fertility. Eugenics Q., 8, 81-91.
43. Hoek, A., Schoemaker, J. and Drexhage, H.A. (1997) Premature ovarian failure and ovarian autoimmunity. Endocr. Rev., 18, 107-134.
44. Holmes-Walker, D.J., Conway, G.S., Honour, J.W., Rumsby, G. and Jacobs, H.S. (1995) Menstrual disturbance and hypersecretion of progesterone in women with congenital adrenal hyperplasia due to 21 hydroxylase deficiency. Clin. Endocrinol., 43, 291-296.
45. Homer, H.A., Li, T.C. and Cooke, I.D. (2000) The septate uterus: a review of management and reproductive outcome. Fertil. Steril., 73, 1-14.
46. Horne, AW., White, J.O., Margara, R.A., Williams, R., Winston, R.M. and Lalani, E. (2001) MUC 1: a genetic susceptibility to infertility? Lancet, 357, 1336-1337.
47. Hornstein, M.D., Davis, O.K., Massey, J.B., Paulson, R.J. and Collins, J.A. (2000) Antiphospholipid antibodies and in vitro fertilization success: a meta-analysis. Fertil. Steril., 73, 330-333.
48. Howe, G., Westhoff, C., Vessey, M. and Yeates, D. (1985) Effects of age, cigarette smoking, and other factors on fertility: findings in a large prospective study. Br. Med. J., 290, 1697-1700.
49. Igarashi, S., Tanno, Y., Onodera, O., Yamazaki, M., Sato, S., Ishikawa, A., Miyatani, N., Nagashima, M., Ishikawa, Y., Sahashi, K. et al. (1992) Strong correlation between the number of CAG repeats in androgen receptor genes and the clinical onset of features of spinal and bulbar muscular atrophy. Neurology, 42, 2300-2302.
50. Iuorno, M.J. and Nestler, J.E. (2001) Insulin-lowering drugs in polycystic ovary syndrome. Obstet. Gynecol. Clin. North Am., 28, 153-164.
51. Jansen, R.P.S. (1982) Spontaneous abortion incidence in the treatment of infertility. Am. J. Obstet. Gynecol., 143, 451-473.
52. Kutteh, W.H., Yetman, D.L., Chantilis, S.J. and Crain, J. (1997) Effect of antiphospholipid antibodies in women undergoing in-vitro fertilization: role of heparin and aspirin. Hum. Reprod., 12, 1171-1175.
53. Legro, R.S. (2000) The genetics of obesity. Lessons from polycystic ovary syndrome. Ann. N.Y. Acad. Sci., 900, 193-202.
54. Legro, R.S., Spielman, R., Urbanek, M., Driscoll, D., Strauss, J.F., III and Dunaif, A. (1998) Phenotype and genotype in polycystic ovary syndrome. Rec. Prog. Hormone Res., 53, 217-256.
55. Liebaers, I., Van Steirteghem, A. and Lissens, W. (2001) Severe male factor: genetic consequences and recommendations for genetic testing. In Gardner, D.K. (ed.), Textbook of Assisted Reproductive Techniques. Martin Dunitz, pp. 285-296.
56. Ligon, A.H. and Morton, C.C. (2001) Leiomyomata: heritability and cytogenetic studies. Hum. Reprod. Update, 7, 8-14.
57. Lissens, W., Mercier, B., Tournaye, H., Bonduelle, M., Ferec, C., Seneca, S., Devroey, P., Silber, S., Van Steirteghem, A. and Liebaers, I. (1996) Cystic fibrosis and infertility caused by congenital bilateral absence of the vas deferens and related clinical entities. Hum. Reprod., 11 (suppl. 4), 55-80.
58. Magenis, R.E. and Chamberlain, J. (1981) Paternal origin of non dysjunction. In de la Cruz, F. and Gerald, P.S. (eds), Trisomy 21 Down's Syndrome. NICHD-Mental Retardation Research Center Series, Baltimore: University Park Press.
59. Mahadevan, M., Tsilfidis, C., Sabourin, L., Shutler, G., Amemiya, C., Jansen, G., Neville, C., Narang, M., Barcelo, J., O'Hoy, K. et al. (1992) Myotonic dystrophy mutation: an unstable CTG repeat in the 3� untranslated region of the gene. Science, 255, 1253-1255.
60. March, C.M. (1995) Intrauterine adhesions. Obstet. Gynecol. Clin. North Am., 22, 491-505.
61. Maroulis, G.B. (1991) Effect of aging on fertility and pregnancy. Semin. Reprod. Endocrinol., 9, 165-175.
62. Marozzi, A., Vegetti, W., Manfredini, E., Tibiletti, M.G., Testa, G., Crosignani, P.G., Ginelli, E., Meneveri R. and DalpraÌ, L. (2000) Mutation analysis of the inhibin alpha gene in a cohort of Italian women affected by ovarian failure. Hum. Reprod., 15, 197-202.
63. McElreavey, K. and Fellous, M. (1997) Sex-determining genes. Trends Endocrinol. Metab., 9, 342-345.
64. McElreavey, K. and Krausz, C. (1999) Male infertility and the Y chromosome. Am. J. Hum. Genet., 64, 928-933.
65. Mineau, G. and Trussel, J. (1982) Specification of married fertility by parents' age, age at marriage, and marital duration. Demography, 19, 335-350.
66. Mitwally, M.F., Kuscu, N.K. and Yalcinkaya, T.M. (1999) High ovulatory rates with use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome. Hum. Reprod., 14, 2700-2703.
67. Morin-Papunen, L.C., Vauhkonen, I., Koivunen, R.M., Ruokonen, A., Martikainen, H.K. and Tapanainen, J.S. (2000) Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study. J. Clin. Endocrinol. Metab., 85, 3161-3168.
68. National Center for Health Statistics (1981) December 1983a, Advance Report of Final Natality Statistics, Monthly Vital Statistics Report, 32, No. 9.
69. Nestler, J.E. (2001) Metformin and the polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 86, 1430.
70. Nestler, J.E., Jakubowicz, D.J., Reamer, P., Gunn, R.D. and Allan, G. (1999) Ovulatory and metabolic effects of D-chiro-inositol in polycystic ovary syndrome. N. Engl. J. Med., 340, 1314-1320.
71. Nieschlag, E. and Behre, H.M. (1992) Male infertility due to testicular dysfunction. In Templeton, A.A. and Drife, J.O. (eds), Infertility. Springer-Verlag, London, pp. 65-79.
72. Norman, R.J., Kidson, W.J., Cuneo, R.C. and Zacharin, M.R. (2001) Metformin and intervention in polycystic ovary syndrome. Endocrine Society of Australia, the Australian Diabetes Society and the Australian Paediatric Endocrine Group. Med. J. Australasia, 174, 580-583.
73. Ostrer, H. (2000) Sexual differentiation. Semin. Reprod. Med., 18, 41-49.
74. Paavonen, J. (1998) Pelvic inflammatory disease: from diagnosis to prevention. Sex. Transmit. Dis., 16, 747.
75. Paavonen, J., Kiviat, N., Brunham, R.C., Stevens, C.E., Kuo, C.C., Stamm, W.E., Miettinen, A., Soules, M., Eschenbach, D.A. and Holmes, K.K. (1985) Prevalence and manifestations of endometritis among women with cervicitis. Am. J. Obstet. Gynecol., 152, 253-280.
76. Perino, A., Vassiliadis, A., Vucetich, A., Colacurci, N., Menato, G., Cignitti, M. and Semprini, A.E. (1997) Short-term therapy for recurrent abortion using intravenous immunoglobulins: results of a double-blind placebo-controlled Italian study. Hum. Reprod., 12, 2388-2392.
77. Rai, R., Cohen, H., Dave, M. and Regan, L. (1997) Randomised controlled trial of aspirin and aspirin plus heparin to pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). Br. Med. J., 314, 253-257.
78. Rai, R., Regan, L., Clifford, K., Pickering, W. and Dave, M. (2001) Antiphospholipid antibodies and beta 2-glycoprotein-I in 500 women with recurrent miscarriage: results of a comprehensive screening approach. Hum. Reprod., 10, 2001-2005.
79. Ramkissoon, Y. and Goodfellow, P. (1996) Early steps in mammalian sex determination. Curr. Opin. Genet. Dev., 6, 316-321.
80. Reimand, K., Peterson, P., Hyoty, H., Uibo, R., Cooke, I., Weetman, A.P. and Krohn, K.J. (2000) 3�-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure. J. Clin. Endocrinol. Metab., 85, 2324-2326.
81. Rein, D.B., Kassler, W.J., Erwin, K.L. and Rabiee, L. (2000) Direct medical cost of pelvic inflammatory disease and its sequelae: decreasing but still substantial. Obstet. Gynecol., 95, 397-401.
82. Roberts, L.M., Shen, J. and Ingraham, H.A. (1999) New solutions to an ancient riddle: defining the differences between Adam and Eve. Am. J. Hum. Genet., 65, 933-942.
83. Robinson, W.C. (1987) Regional variation in the age-specific natural fertility curve. J. Biosoc. Sci., 19, 57-64.
84. Rugarli, E.L. (1999) Kallmann syndrome and the link between olfactory and reproductive development. Am. J. Hum. Genet., 65, 943-948.
85. Rushworth, F.H., Backos, M., Rai, R., Chilcott, I.T., Baxter, N. and Regan, L. (2000) Prospective pregnancy outcome in untreated recurrent miscarriers with thyroid autoantibodies. Hum. Reprod., 15, 1637-1639.
86. Santen, R.J. (1999) The testis: function and dysfunction. In Yen, S.S.C., Jaffe, R.B. and Barbieri, R.L. (eds), Reproductive Endocrinology. 4th edition. W.B.Saunders, Philadelphia, pp. 632-675.
87. SchaÌnzer, W. (1998) Abuse of androgens and detection of illegal use. In Nieschlag, E. and Behre, H.M. (eds), Testosterone: Action, deficiency and substitution. Springer, Berlin, pp. 545-565.
88. Seminara, S.B., Oliveira, L.M., Beranova, M., Hayes, F.J. and Crowley, W.F., Jr (2000) Genetics of hypogonadotropic hypogonadism. J. Endocrinol. Invest., 23, 560-565.
89. Simpson, J.L. (1985) Genes and chromosomes that cause female infertility. Fertil. Steril., 44, 725-739.
90. Simpson, J.L. (2000) Genetic factors in common disorders of female infertility. Reprod. Med. Rev., 8, 173-202.
91. Sinclair, A.H., Berta, P., Palmer, M.S., Hawkins, J.R., Griffiths, B.L., Smith, M.J., Foster, JW., Frischauf, A.M., Lovell-Badge, R. and Goodfellow, P.N. (1990) A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature, 346, 240-244.
92. Snick, H.K.A., Snick, T.S., Evers, J.L.H. and Collins, J.A. (1997). The spontaneous pregnancy prognosis in untreated subfertile couples: the Walcheren primary care study. Hum. Reprod., 12, 1582-1588.
93. Stenchever, M.A., Droegenmueller W., Herbt, A.L. and Mishell, D.R., Jr (2001) Comprehensive Gynecology. 4th edition. Mosby Inc., St Louis, Missouri.
94. Stephenson, M.D. (1996) Frequency of factors associated with habitual abortion in 197 couples. Fertil. Steril., 66, 24-29.
95. Stephenson, M.D., Dreher, K., Houlihan, E. and Wu, V. (1998) Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: a prospective, randomized, double blinded, placebo controlled trial. Am. J. Reprod. Immunol., 39, 82-88.
96. Stone, K.M., Grimes, D.A. and Magder, L.S. (1986) Primary prevention of sexually transmitted diseases. JAMA, 255, 1763-1768.
97. Templeton, A. and Morris, J.K. (1998). Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization. N. Engl. J. Med., 339, 573-577.
98. Templeton, A., Fraser, C. and Thompson, B. (1991) Infertility - epidemiology and referral practice. Hum. Reprod., 10, 1391-1396.
99. Templeton, A., Morris, J.K. and Parslow, W. (1996). Factors that affect outcome of in vitro fertilisation treatment. Lancet, 348, 1402-1406.
100. The EHSRE Capri Workshop Group (2000) Optimal use of infertility diagnostic tests and treatments. Hum. Reprod., 15, 723-732.
101. The German RSA/IVIG Group (1994) Intravenous immunoglobulin in the prevention of recurrent miscarriage. Br. J. Obstet. Gynaecol., 101, 1072-1077.
102. Treolar, A.E., Boyton, R.E., Behr, B.G. and Brown, B.W. (1967) Variation of the human menstrual cycle through reproductive life. Int. J. Fertil., 12, 77-126.
103. Van Assche, E., Bonduelle, M., Tournaye, H., Joris, H., Verheyen, G., Devroey, P., Van Steirteghem, A. and Liebaers, I. (1996) Cytogenetics of infertile men. Hum. Reprod., 11 (suppl. 4), 1-26.
104. Vegetti, W., Tibiletti, M.G., Testa, G., De Lauretis Yankowski, L., Alagna F., Castoldi, E., Taborelli, M., Motta, T., Bolis, P.F., DalpraÌ, L. et al. (1998) Inheritance in idiopathic premature ovarian failure: analysis of 71 cases. Hum. Reprod., 13, 1796-1800.
105. Veitia, R.A., Salas-Cortes, L., Ottolenghi, C., Pailhoux, E., Cotinot, C. and Fellous, M. (2001) Testis determination in mammals: more questions than answers. Mol. Cell. Endocrinol., 179, 3-16.
106. Vercellini, P., Maddalena, S., De Giorgi, O., Aimi, G. and Crosignani, P.G. (1998) Abdominal myomectomy for infertility: a comprehensive review. Hum. Reprod, 13, 873-879.
107. Vercellini, P., Zaina, B., Yaylayan, L., Pisacreta, A., De Giorgi, O. and Crosignani, P.G. (1999) Hystero-scopic myomectomy: long-term effects on menstrual pattern and fertility. Obstet. Gynecol., 94, 341-347.
108. Verkerk, A.J., Pieretti, M., Sutcliffe, J.S., Fu, Y.H., Kuhl, D.P., Pizzuti, A., Reiner, O., Richards, S., Victoria, M.F., Zhang, F.P. et al. (1990) Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 65, 905-914.
109. Warren, S.T. and Ashley, C.T. (1995) Triplet repeat expansion mutations: the example of fragile X syndrome. Annu. Rev. Neurosci., 18, 77-99.
110. Westrom, L., Joesoef, R., Reynolds, G., Hagdu, A. and Thompson, S.E. (1992) Pelvic inflammatory disease and fertility: a cohort study of 1844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results. Sex. Transmit. Dis., 19, 185-192.
111. Wheatcroft, N.J., Rogers, C.A., Metcalfe, R.A., Lenton, E.A., Cooke, I.D. and Weetman, A.P. (1997) Is subclinical ovarian failure an autoimmune disease? Hum. Reprod., 12, 244-249.
112. Wolner-Hanssen, P. (1995) Silent pelvic inflammatory disease: is it overstated? Obstet. Gynecol., 86, 321-324.
113. Wolner-Hanssen, P., Svensson, L., Mardh, P.A. and Westrom, L. (1985) Laparoscopic findings and contraceptive use in women with signs and symptoms of acute salpingitis. Obstet. Gynecol., 66, 232-233.
114. World Health Organization (2001) Department of Reproductive Health and Research. Annual Technical Report 2000+. WHO/RHR/01.11. World Health Organization, Geneva.