Contemporary strategies for the prevention of stress-related mucosal bleeding

American Journal of Health-System Pharmacy

Volumn 62, Issue SUPPL. 2, 2005, Pages

  Martindale, Robert G ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Critical illness; Gastrointestinal drugs; Gastrointestinal hemorrhage; Mortality; Nutrition; Tolerance

Indexed keywords

ANTACID AGENT; CIMETIDINE; HEPARIN; HISTAMINE H2 RECEPTOR ANTAGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; RANITIDINE; SUCRALFATE;

ADULT; ANAMNESIS; ARTIFICIAL VENTILATION; BLOOD CLOTTING DISORDER; CASE REPORT; CLINICAL FEATURE; CLINICAL TRIAL; CONFERENCE PAPER; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; ENTERIC FEEDING; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL TRACT FUNCTION; HOSPITAL INFECTION; HUMAN; HYPOVOLEMIA; INTENSIVE CARE UNIT; MORTALITY; MUCOSAL BLEEDING; PANCREATITIS; PATHOPHYSIOLOGY; PEPTIC ULCER; PERFUSION; PNEUMONIA; PRIORITY JOURNAL; PROPHYLAXIS; RESPIRATORY FAILURE; STOMACH PH; STRESS; STRESS ULCER;

EID: 18644377612     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajhp/62.10_supplement_2.s11     Document Type: Conference Paper

References (39)

1. Cook DJ, Fuller HD, Guyatt GH et al. Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med. 1994; 330:377-81.
2. Mutlu GM, Mutlu EA, Factor P. GI complications in patients receiving mechanical ventilation. Chest. 2001; 119:1222-41.
3. ASHP Therapeutic Guidelines on Stress Ulcer Prophylaxis. Am J Health-Syst Pharm. 1999; 56:347-79.
4. Cook D, Heyland D, Griffith L et al. Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med. 1999; 27:2812-7.
5. Cook D, Guyatt G, Marshall J et al. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. N Engl J Med. 1998; 338:791-7.
6. Fiddian-Green RG, McGough E, Pittenger G et al. Predictive value of intramural pH and other risk factors for massive bleeding from stress ulceration. Gastroenterology. 1983; 85:613-20.
7. Howden CW. Use of proton-pump inhibitors in complicated ulcer disease and upper gastrointestinal tract bleeding. Am J Health-Syst Pharm. 1999; 56(suppl 4):S5-11.
8. Goldin GF, Peura DA. Stress-related mucosal damage. What to do or not to do. Gastrointest Endosc Clin N Am. 1996; 6:505-26.
9. Wolfe MM, Sachs G. Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology. 2000; 118(2 suppl 1):S9-31.
10. Daneshmend TK, Hawkey CJ, Langman MJ et al. Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. BMJ. 1992; 304:143-7.
11. Silverstein FE, Gilbert DA, Tedesco FJ et al. The national ASGE survey on upper gastrointestinal bleeding. II. Clinical prognostic factors. Gastrointest Endosc. 1981; 27:80-93.
12. Silen W. The prevention and management of stress ulcers. Hosp Pract. 1980; 15:93-100.
13. Lewis JD, Shin EJ, Metz DC. Characterization of gastrointestinal bleeding in severely ill hospitalized patients. Crit Care Med. 2000; 28:46-50.
14. Martin LF, Booth FV, Karlstadt RG et al. Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Crit Care Med. 1993; 21:19-30.
15. Schmidt H, Martindale R. The gastrointestinal tract in critical illness. Curr Opin Clin Nutr Metab Care. 2001; 4:547-51.
16. Pingleton SK, Hadzima SK. Enteral alimentation and gastrointestinal bleeding in mechanically ventilated patients. Crit Care Med. 1983; 11:13-6.
17. Raff T, Germann G, Hartmann B. The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient. Burns. 1997; 23:313-8.
18. Gurman G, Samri M, Sarov B et al. The rate of gastrointestinal bleeding in a general ICU population: a retrospective study. Intensive Care Med. 1990; 16:44-9.
19. MacLaren R, Jarvis CL, Fish DN. Use of enteral nutrition for stress ulcer prophylaxis. Ann Pharmacother. 2001; 35:1614-23.
20. Kalff JC, Turler A, Schwarz NT et al. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg. 2003; 237:301-15.
21. Prod'hom G, Leuenberger P, Koerfer J et al. Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer. A randomized controlled trial. Ann Intern Med. 1994; 120:653-62.
22. Eddleston JM, Vohra A, Scott P et al. A comparison of the frequency of stress ulceration and secondary pneumonia in sucralfate- or ranitidine-treated intensive care unit patients. Crit Care Med. 1991; 19:1491-6.
23. Driks MR, Craven DE, Celli BR et al. Nosocomial pneumonia in intubated patients given sucralfate as compared with antacids or histamine type 2 blockers. The role of gastric colonization. N Engl J Med. 1987; 317:1376-82.
24. Simms HH, DeMaria E, McDonald L et al. Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial. J Trauma. 1991; 31: 531-6.
25. Ryan P, Dawson J, Teres D et al. Nosocomial pneumonia during stress ulcer prophylaxis with cimetidine and sucralfate. Arch Surg. 1993; 128:1353-7.
26. Tagamet package insert. Research Triangle Park, NC: GlaxoSmithKline; June 2002.
27. Ostro MJ, Russell JA, Soldin SJ et al. Control of gastric pH with cimetidine: boluses versus primed infusions. Gastroenterology. 1985; 89:532-7.
28. Cook DJ, Reeve BK, Guyatt GH et al. Stress ulcer prophylaxis in critically ill patients. Resolving discordant metaanalyses. JAMA. 1996; 275:308-14.
29. Azevedo JR, Soares MG, Silva C et al. Prevention of stress ulcer bleeding in high risk patients: comparison of three drugs. Crit Care Med. 1999; 27:A145. Abstract 411.
30. Levy MJ, Seelig CB, Robinson NJ et al. Comparison of omeprazole and ranitidine for stress ulcer prophylaxis. Dig Dis Sci. 1997; 42:1255-9.
31. Lasky MR, Metzler MH, Phillips JO. A prospective study of omeprazole suspension to prevent clinically significant gastrointestinal bleeding from stress ulcers in mechanically ventilated trauma patients. J Trauma. 1998; 44:527-33.
32. Phillips JO, Metzler MH, Palmieri MT et al. A prospective study of simplified omeprazole suspension for the prophylaxis of stress-related mucosal damage. Crit Care Med. 1996; 24:1793-800.
33. Conrad SA, Gabrielli A, Margolis B et al. Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients. Crit Care Med. 2005; 33:1-6.
34. Somberg L, Karlstadt R, Blatcher D et al. Intermittent intravenous pantoprazole (P) maintains control of gastric pH in intensive care unit patients. Am J Gastroenterol. 2002; 97:347. Abstract.
35. Pisegna JR, Martindale RG. Acid suppression in the perioperative period. J Clin Gastroenterol. 2005; 39:10-6.
36. Pisegna JR, Oh D, Karlstadt R et al. Perioperative use of i.v. pantoprazole (IVP) effectively controls gastric volume and acid output in NPO patients in the perioperative period: analysis of results from the perioperative IVP pilot study. Crit Care Med. 2003; 31:A84. Abstract 308.
37. Dial S, Alrasadi K, Manoukian C et al. Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies. CMAJ. 2004; 171:33-8.
38. Choo D, Khwaja K, Nori K et al. In vivo characterization of the molecular-genetic changes in gastric mucosa during the development of acute gastritis and stress ulceration. J Trauma. 2002; 52:720-5.
39. Wischmeyer PE, Riehm J, Singleton KD et al. Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition. 2003; 19:1-6.