Biocatalytic preparation of a chiral synthon for a vasopeptidase inhibitor: Enzymatic conversion of N2-[N-Phenylmethoxy)carbonyl] L-homocysteinyl]- L-lysine (1- > 1’)-disulfide to [4S-(4I,7I,10aJ)] 1-octahydro-5-oxo-4-[phenylmethoxy)carbonyl]amino]-7H-pyrido-[2,1 -b] [1,3]thiazepine-7-carboxylic acid methyl ester by a novel L-lysine ε-aminotransferase

Enzyme and Microbial Technology

Volumn 27, Issue 6, 2000, Pages 376-389

  Patel, Ramesh N ^a   Banerjee, Amit ^a   Nanduri, Venkata B ^a   Goldberg, Steven L ^a   Johnston, Robert M ^a   Hanson, Ronald L ^a   McNamee, Clyde G ^a   Brzozowski, David B ^a   Tully, Thomas P ^a   Ko, Raphael Y ^a   LaPorte, Thomas L ^a   Cazzulino, Dana L ^a   Swaminathan, Shankar ^a   Chen, Chien Kuang ^a   Parker, Larry W ^a   Venit, John J ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Chiral synthons; L lysine aminotransferase

Indexed keywords

AMINES; ANIMAL CELL CULTURE; BIOCONVERSION; BIOSYNTHESIS; CARBOXYLIC ACIDS; CATALYST ACTIVITY; GENETIC ENGINEERING; OXIDATION; POLYPEPTIDES; PURIFICATION;

AMINOTRANSFERASE; BIOCATALYTIC PREPARATION; CHIRAL SYNTHON; VASOPEPTIDASE INHIBITOR;

ENZYME INHIBITION;

AMINOTRANSFERASE; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; LYSINE DERIVATIVE; OMAPATRILAT;

ARTICLE; BIOTRANSFORMATION; CATALYSIS; DRUG SYNTHESIS; ENZYME MECHANISM; FERMENTATION; MOLECULAR CLONING; NONHUMAN; OXIDATION; SPHINGOMONAS PAUCIMOBILIS;

SPHINGOMONAS PAUCIMOBILIS;

EID: 18544410440     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(00)00233-7     Document Type: Article

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