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Volumn 35, Issue 9, 1994, Pages 1393-1396

A synthetic route for the generation of C-7 substituted azepinones

Author keywords

[No Author keywords available]

Indexed keywords

AZEPINE DERIVATIVE;

EID: 0028215536     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)76227-7     Document Type: Article
Times cited : (19)

References (36)
  • 1
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    • Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog
    • For some varied examples, see
    • (1980) Science , vol.210 , pp. 656
    • Freidinger1    Veber2    Perlow3
  • 12
    • 84912982657 scopus 로고    scopus 로고
    • reference 2
  • 19
    • 0025734567 scopus 로고
    • Synthesis of .alpha.-benzyl .gamma.-lactam, .alpha.-benzyl .delta.-lactam, and .alpha.-benzylproline derivatives as conformationally restricted analogs of phenylalaninamide
    • (1991) The Journal of Organic Chemistry , vol.56 , pp. 3900
    • Holladay1    Nadzan2
  • 26
    • 84912988924 scopus 로고    scopus 로고
    • The propensity of ε-oxo carbamates and amides to cyclize to their corresponding hemi-aminals, especially under acidic or basic conditions, necessitated the use of phthalimido versus Boc protection of the amine functionality.
  • 27
    • 49549128832 scopus 로고
    • Syntheses of γ,δ-unsaturated alcohols from allylsilanes and carbonyl compounds in the presence of titanium tetrachloride
    • (1976) Tetrahedron Letters , vol.16 , pp. 1295
    • Hosomi1    Sakurai2
  • 28
    • 84912991008 scopus 로고    scopus 로고
    • 3Al in toluene under indentical circumstances lead to extensive decomposition and a low yield of product. Dichloromethane was used as solvent in both cases.
  • 30
    • 84912957086 scopus 로고    scopus 로고
    • The use of methanol as solvent in the hydrogenation of 6a or 6b gives poor yields of the corresponding amino acids.
  • 31
    • 84912962439 scopus 로고    scopus 로고
    • 2)
  • 32
    • 84912980718 scopus 로고    scopus 로고
    • A variety of bases (NaOH, NaH, t-BuOK), alkylating agents (ethyl bromoacetate, ethyl chloroacetate) and solvents (THF, DMF, t-BuOH) were tried.
  • 33
    • 84913009135 scopus 로고    scopus 로고
    • 4), filtered and evaporated. Flash chromatography on silica gel affords the desired product.
  • 35
    • 0001323711 scopus 로고
    • Chiral titanium complexes for enantioselective addition of nucleophiles to carbonyl groups
    • (1992) Chemical Reviews , vol.92 , pp. 807
    • Duthaler1    Hafner2
  • 36


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.