Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by β-catenin

Cancer Research

Volumn 60, Issue 13, 2000, Pages 3354-3358

  Kawasoe, Teru ^a,c   Furukawa, Yoichi ^a   Daigo, Yataro ^a   Nishiwaki, Tadashi ^a   Ishiguro, Hideyuki ^a   Fujita, Manabu ^a   Satoh, Seiji ^a   Miwa, Nobutomo ^a   Nagasawa, Yutaka ^b   Miyoshi, Yasuo ^b   Ogawa, Michio ^c   Nakamura, Yusuke ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL ADHESION; CHROMOSOME 7P; COLON CARCINOGENESIS; COLON POLYPOSIS; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TRANSFER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; BETA CATENIN; CADHERINS; COLONIC NEOPLASMS; COS CELLS; CYTOSKELETAL PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; L CELLS (CELL LINE); MICE; ONCOGENE PROTEINS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 18544394902     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Nakamura, Y. Cleaning up on β-catenin. Nat. Med., 3: 499-500, 1997.
2. Hulsken, J., Birchmeier, W., and Behrens, J. E-Cadherin and APC compete for the interaction with β-catenin and the cytoskeleton. J. Cell Biol., 127: 2061-2069, 1994.
3. Willert, K., and Nusse, R. β-Catenin: a key mediator of Wnt signaling. Curr. Opin. Genet. Dev., 8: 95-102, 1998.
4. Wieschaus, E., and Riggleman, R. Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis. Cell, 49: 177-184, 1987.
5. Funayama, N., Fagotto, F., McCrea, P., and Gumbiner, B. M. Embryonic axis induction by the armadillo repeat domain of β-catenin: evidence for intracellular signaling. J. Cell Biol., 128: 959-968, 1995.
6. He, T. C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., and Kinzler, K. W. Identification of c-MYC as a target of the APC pathway. Science (Washington DC), 281: 1509-1512, 1998.
7. Tetsu, O., and McCormick, F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (Lond.), 398: 422-426, 1999.
8. Crawford, H. C., Fingleton, B. M., Rudolph-Owen, L. A., Goss, K. J., Rubinfeld, B., Polakis, P., and Matrisian, L. M. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors. Oncogene, 18: 2883-2891, 1999.
9. Pennica, D., Swanson, T. A., Welsh, J. W., Roy, M. A., Lawrence, D. A., Lee, J., Brush, J., Taneyhill, L. A., Deuel, B., Lew, M., Watanabe, C., Cohen, R. L., Melhem, M. F., Finley, G. G., Quirke, P., Goddard, A. D., Hillan, K. J., Gurney, A. L., Botstein, D., and Levine, A. J. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc. Natl. Acad. Sci. USA, 95: 14717-14722, 1998.
10. Mann, B., Gelos, M., Siedow, A., Hanski, M. L., Gratchev, A., Ilyas, M., Bodmer, W. F., Moyer, M. P., Riecken, E. O., Buhr, H. J., and Hanski, C. Target genes of β-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc. Natl. Acad. Sci. USA, 16: 1603-1608, 1999.
11. Ishiguro, H., Funikawa, Y., Daigo, Y., Miyoshi, Y., Nagasawa, Y., Nishiwaki, T., Kawasoe, T., Fujita, M., Satoh, S., Miwa, N., Fujii, Y., and Nakamura, Y. Isolation and characterization of human NBL4, a gene involved in the β-catenin/Tcf signaling pathway. Jpn. J, Cancer Res., in press, 2000.
12. Nagasawa, Y., Miyoshi, Y., Iwao, K., Shinomura, Y., Matsuzawa, Y., and Nakamura, Y. Transformation and morphological changes of murine L cells by transfection with a mutated form of β-catenin. Cancer Res., 59: 3539-3542, 1999.
13. Yoshikawa, Y., Mukai, H., Asada, K., Hino, F., and Kato, I. Differential display with carboxy-X-rhodamine-labeled primers and the selection of differentially amplified cDNA fragments without cloning. Anal. Biochem., 256: 82-91, 1998.
14. Munemitsu, S., Souza, B., Muller, O., Albert, I., Rubinfeld, B., and Polakis, P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA, 92: 3046-3050, 1995.
15. McGrory, W. J., Bautista, D. S., and Graham, F. L. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology, 163: 614-617, 1988.
16. Van de Wetering, M., Castrop, J., Korinek, V., and Clevers, H. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol. Cell. Biol., 16: 745-752, 1996.
17. Medina, A., Wendler, S. R., and Steinbeisser, H. Cortical rotation is required for the correct spatial expression of nr3, sia and gsc in Xenopus embryos. Int. J. Dev. Biol., 41: 741-745, 1997.
18. McGrew, L. L., Takemaru, K., Bates, R., and Moon, R. T. Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus. Mech. Dev., 87: 21-32, 1999.
19. Laurent, M. N., Blitz, I. L., Hashimoto, C., Rothbacher, U., and Cho, K. W. The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer. Development (Camb.), 124: 4905-4916, 1997.
20. Riese, J., Yu, X., Munnerlyn, A., Eresh, S., Hsu, S. C., Grosschedl, R., and Bienz, M. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell, 88: 777-787, 1997.
21. Gradl, D., Kuhl, M., and Wedlich, D. The Wnt/Wg signal transducer β-catenin controls fibronectin expression. Mol. Cell. Biol., 19: 5576-5587, 1999.
22. Rocheleau, C. E., Yasuda, J., Shin, T. H., Lin, R., Sawa, H., Okano, H., Priess, J. R., Davis, R. J., and Mello, C. C. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell, 97: 717-726, 1999.
23. Matsushita, M., Matsuzaki, K., Date, M., Watanabe, T., Shibano, K., Nakagawa, T., Yanagitani, S., Amoh, Y., Takemoto, H., Ogata, N., Yamamoto, C., Kubota, Y., Seki, T., Inokuchi, H., Nishizawa, M., Takada, H., Sawamura, T., Okamura, A., and Inoue, K. Down-regulation of TGF-β receptors in human colorectal cancer: implications for cancer development. Br. J. Cancer. 80: 194-205, 1999.
24. Schuhmacher, C., Becker, I., Oswald, S., Atkinson, M. J., Nekarda, H., Becker, K. F., Mueller, J., Siewert, J. R., and Hofler, H. Loss of immunohistochemical E-cadherin expression in colon cancer is not due to structural gene alterations. Virchows Arch., 434: 489-495, 1999.
25. Takaoka, A., Hinoda, Y., Satoh, S., Adachi, Y., Itoh, F., Adachi, M., and Imai, K. Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene. Oncogene, 16: 1443-1453, 1998.
26. Lorentz, O., Cadoret, A., Duluc, I., Capeau, J., Gespach, C., Cherqui, G., and Freund, J. N. Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene, 18: 87-92, 1999.
27. Mallo, G. V., Rechreche, H., Frigerio, J. M., Rocha, D., Zweibaum, A., Lacasa, M., Jordan, B. R., Dusetti, N. J., Dagom, J. C., and Iovanna, J. L. Molecular cloning, sequencing and expression of the mRN A encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int. J. Cancer, 74: 35-44, 1997.
28. Tamai, Y., Nakajima, R., Ishikawa, T., Takaku, K., Seldin, M. F., and Taketo, M. M. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res., 59: 2965-2970, 1999.