Penile erectile responses to electric stimulation are enhanced by a new phosphodiesterase type-5 inhibitor

International Journal of Urology

Volumn 12, Issue 3, 2005, Pages 299-304

  Yu, Jae Young ^a   Kang, Kyung Koo ^a   Yoo, Moohi ^a   Kwon, Jong Won ^a  

^a Dong A Pharmaceutical Company   (South Korea)

Author keywords

DA 8159; Erectile function; Intracavernosal pressure; Phosphodiesterase inhibitor

Indexed keywords

PHOSPHODIESTERASE V INHIBITOR; UDENAFIL;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ELECTRIC STIMULATION; HYPOGASTRIC PLEXUS; MALE; MANOMETRY; PENILE ERECTION; PENIS; PHOSPHODIESTERASE INHIBITORS; PRESSURE; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 18444385679     PISSN: 09198172     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2005.01039.x     Document Type: Article

References (15)

1. Burnett AL. Nitric oxide in the penis; physiology and pathology. J. Urol. 1997; 157: 320-4.
2. Metro MJ, Broderick GA. Diabetes and vascular impotence: does insulin dependence increase the relative severity? Int. J. Impot. Res. 1999; 11: 87-9.
3. Steger RW, Amador A, Lam E, Rathert J, Weis J, Smith MS. Streptozotocin-induced deficits in sex behavior and neuroendocrine function in male rats. Endocrinology 1989; 124: 1737-43.
4. Doh H, Shin CY, Son M et al. Mechanism of erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159. Arch. Pharm. Res. 2002; 25: 873-8.
5. Kang KK, Choi SM, Ahn GJ, Kwon JW, Kim WB. The effect of DA-8159 on corpus cavernosal smooth muscle relaxation and penile erection in diabetic rabbits. Urol. Res. 2004; 32: 107-11.
6. Kang KK, Ahn GJ, Ahn BO, Yoo M, Kim WB. DA-8159, a new PDE5 inhibitor, induces penile erection in conscious and acute spinal cord injured rabbits. Eur. Urol. 2003; 43: 689-95.
7. Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 1995; 75: 725-48.
8. Francis SH, Turko IV, Corbin JD. Cyclic nucleotide phosphodiesterases: relating structure and function. Prog. Nucleic Acid Res. Mol. Biol. 2001; 65: 1-52.
9. Qiu Y, Bhattacharjee S, Kraft P et al. Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859. Eur. J. Pharmacol. 2003; 472: 73-80.
10. Maw GN, Allerton CM, Gbekor E, Million WA. Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors. Bioorg. Med. Chem. Lett. 2003; 13: 1425-8.
11. Bahng MY, Kang KK, Ahn BO et al. Tolerance and pharmacokinetics of single-dose DA-8159 in healthy male. Int. J. Impot. Res. 2002; 14 (Suppl. 3): S101.
12. Amakye D, Ward J, Bryson S, Han K. DA-8159-phase I studies to investigate the safety and pharmacokinetics in healthy male Caucasian subjects. Clin. Pharmacol. Ther. 2004; 75: 86.
13. Padma-Nathan H, Paick JS, Ahn BO, Kang KK, Bahng MY, Kim WB. Phase I, double-blind, placebo-controlled study in healthy male subjects to investigate the safety, tolerability, and pharmacokinetics of DA-8159. J. Urol. 2004; 171: S234
14. Dai Y, Pollock DM, Lewis RL, Wingard CJ, Stopper VS, Mills TM. Receptor-specific influence of endothelin-1 in the erectile response of the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000; 279: 25-30.
15. Ueno N, Iwamoto Y, Segawa N, Kinoshita M, Ueda H, Katsuoka Y. The effect of sildenafil on electrostimulation-induced erection in the rat model. Int. J. Impot. Res. 2002; 14: 251-5.