Distinct IA-2 autoantibody epitope recognition between childhood-onset and adult-onset type 1 diabetes

Annals of the New York Academy of Sciences

Volumn 958, Issue , 2002, Pages 235-240

  Kawasaki, Eiji ^a   Sera, Yasunori ^a   Abiru, Norio ^a   Yamauchi, Mikako ^a   Ozaki, Masako ^a   Yamakawa, Kenichi ^a   Abe, Takahiro ^a   Uotani, Shigeo ^a   Yamasaki, Hironori ^a   Yamaguchi, Yoshihiko ^a   Eguchi, Katsumi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Adult onset diabetes; Autoantibodies; Childhood onset diabetes; Diabetes; Epitopes; Insulinoma associated antigen 2

Indexed keywords

AUTOANTIBODY; EPITOPE; GLUTAMATE DECARBOXYLASE ANTIBODY; INSULIN ANTIBODY; INSULINOMA ASSOCIATED ANTIGEN 2 ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIGEN BINDING; ANTIGEN RECOGNITION; AUTOIMMUNITY; CHILD; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; ISOTOPE LABELING; JUVENILE DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MATURITY ONSET DIABETES MELLITUS; PREVALENCE; PROTEIN DOMAIN;

EID: 18444379942     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb02977.x     Document Type: Conference Paper

References (13)

1. The pathogenesis of insulin-dependent diabetes mellitus
2. A comparison of childhood and adult type I diabetes mellitus
3. Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes
4. Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases
5. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
6. IA-2 (islet cell antigen 512) is the primary target of humoral autoimmunity against type 1 diabetes-associated tyrosine phosphatase autoantigens
7. Evaluation of islet cell antigen (ICA) 512/IA-2 autoantibody radioassays using overlapping ICA512/IA-2 constructs
8. IA-2 antibodies: A sensitive marker of IDDM with clinical onset in childhood and adolescence
9. Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes
10. Diabetes Mellitus: Report of a WHO Study Group
11. Autoantibodies to multiple islet autoantigens in patients with abrupt onset type 1 diabetes and diabetes diagnosed with urinary glucose screening
12. Definition of multiple ICA512/ phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes
13. Immunological heterogeneity in type I diabetes: Presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease