Aromatase inhibition by 4β,5β-epoxides of 16α- hydroxyandrostenedione and its 19-oxygenated analogs, potential precursors of estriol production in the feto-placental unit

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 12, 2002, Pages 1566-1569

  Numazawa, Mitsuteru ^a   Yoshimura, Akiko ^a   Watari, Yoko ^a   Matsuzaki, Hisao ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

4 ,5 epoxy 16 hydroxy steroid; Aromatase; Gas chromatography mass spectrometry; Non competitive inhibition; Time dependent inactivation

Indexed keywords

ANDROSTENEDIONE DERIVATIVE; AROMATASE; AROMATASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID; 16 HYDROXYANDROST 4 EN 3,17 DIONE; 16-HYDROXYANDROST-4-EN-3,17-DIONE; ANDROSTENEDIONE; DRUG DERIVATIVE; ENZYME INHIBITOR; EPOXIDE; ESTRIOL;

AROMATIZATION; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; MASS SPECTROMETRY; MICROSOME; OXYGENATION; PLACENTA; PROTEIN BINDING; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; FETUS; METABOLISM;

ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITORS; ENZYME INHIBITORS; EPOXY COMPOUNDS; ESTRIOL; FETUS; HUMANS; PLACENTA;

EID: 1842870847     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.1566     Document Type: Article

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