Time-dependent aromatase inactivation by 4β,5β-epoxides of the natural substrate androstenedione and its 19-oxygenated analogs

Steroids

Volumn 67, Issue 3-4, 2002, Pages 185-193

  Numazawa, Mitsuteru ^a   Yoshimura, Akiko ^a   Tachibana, Mii ^a   Shelangouski, Momoko ^a   Ishikawa, Maya ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

4 ,5 Epoxyandrostenediones; Affinity labeling agent; Aromatase; Biochemical aromatization; Human placental microsomes; Suicide substrate

Indexed keywords

10 HYDROXYANDROST 4 EN 17 ONE; 4BETA,5BETA EPOXY 19 HYDROXYANDROSTENEDIONE; 4BETA,5BETA EPOXY 19 OXOANDROSTENEDIONE; 4BETA,5BETA EPOXYANDROSTENEDIONE; ANDROSTANE DERIVATIVE; AROMATASE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INCUBATION TIME; MASS SPECTROMETRY; MICROSOME; PLACENTA; TECHNIQUE;

ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITORS; BINDING, COMPETITIVE; ENZYME INHIBITORS; EPOXY COMPOUNDS; ESTRADIOL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; KINETICS; MICROSOMES; NADP; PLACENTA; PREGNANCY; SUBSTRATE SPECIFICITY;

EID: 0036168536     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(01)00151-9     Document Type: Article

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