Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists

Farmaco

Volumn 57, Issue 11, 2002, Pages 917-923

  Chilmonczyk, Zdzisław ^a,b   Krajewski, Krzysztof J ^c   Cybulski, Jacek ^c  

^a NATIONAL MEDICINES INSTITUTE   (Poland)

^b IPJ   (Poland)

^c INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

Author keywords

5 HT1A receptor ligands; Buspirone; Gepirone; Rigid analogues

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 4,4 DIMETHYL 1 [4 (4 PYRIMIDIN 2 YLPIPERAZIN 1 YL)CYCLOHEXYL]PIPERIDINE 2,6 DIONE; 8 AZA 8 [4 (4 PYRIMIDIN 2 YLPIPERAZIN 1 YL)CYCLOHEXYL]SPIRO[4.5]DECANE 7,9 DIONE; BUSPIRONE; GEPIRONE; PARTIAL AGONIST; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; DRUG DERIVATIVE; PYRIMIDINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; NONHUMAN; RAT; RECEPTOR AFFINITY; SOLID STATE; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; THEORETICAL MODEL; BINDING COMPETITION; BRAIN LEVEL; CHEMICAL STRUCTURE; CONFORMATION; DRUG EFFECT; INFRARED SPECTROPHOTOMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

BINDING, COMPETITIVE; BRAIN CHEMISTRY; BUSPIRONE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIMIDINES; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SPECTROPHOTOMETRY, INFRARED;

EID: 1842867322     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)01279-X     Document Type: Article

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