Apoptosis a relevant therapeutic target in rheumatoid arthritis?

Rheumatology

Volumn 43, Issue 4, 2004, Pages 405-407

  Smith, Malcolm D ^a   Walker, J G ^a  

^a REPATRIATION GENERAL HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; FAS LIGAND; INTERLEUKIN 1; LIGAND; PROTEIN MDM2; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; AUTOIMMUNE DISEASE; CELL GROWTH; DISEASE COURSE; DNA REPAIR; DRUG TARGETING; EDITORIAL; ENZYME ACTIVATION; FIBROBLAST CULTURE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; MACROPHAGE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANTIRHEUMATIC AGENTS; APOPTOSIS; ARTHRITIS, RHEUMATOID; HUMANS;

EID: 1842866231     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keh084     Document Type: Editorial

References (22)

1. Tak PP, Bresnihan B. The pathogenesis and prevention of joint damage in rheumatoid arthritis. Advance from synovial biopsy and tissue analysis. Arthritis Rheum 2000;43:2619-33.
2. Firestein GS. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum 1996;39:1781-90.
3. Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid arthritis synovium. J Clin Invest 1995;96:1631-8.
4. Perlman H, Pagliari LJ, Volin MV. Regulation of apoptosis and cell cycle activity in rheumatoid arthritis. Current Mol Med 2001;1:597-608.
5. Vaishnaw AK, McNally JD, Elkon KB. Apoptosis in the rheumatic diseases. Arthritis Rheum 1997;40:1917-27.
6. Perlman H, Pagliari LJ, Liu H, Koch AE, Haines GK, Pope RM. Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1 beta-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis. Arthritis Rheum 2001;44:21-30.
7. Schedel J, Gay RE, Kuenzler P et al. FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis. Arthritis Rheum 2002;46:1512-18.
8. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediate apoptosis. Nature 1992;356:314-17.
9. Rieux-Laucat FLe, Deist F, Hivroz C et al. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 1995;268:1347-9.
10. Itoh K, Hase H, Kojima H, Saotome K, Nishioka K, Kobata T. Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts. Rheumatology 2004;43:277-85. First published November 17, 2003, 10.1093/rheumatology/keh039.
11. Nakajima T, Aono H, Hasunuma T et al. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 1995;38:485-91.
12. Hasunuma T, Hoa TTM, Aono H et al. Induction of Fas-dependent apoptosis in synovial infiltrating cells in rheumatoid arthritis. International Immunol 1996;8:1595-602.
13. Asahara H, Hasumuna T, Kobata T et al. Expression of Fas antigen and Fas ligand in rheumatoid synovial tissue. Clin Immunol Immunopathol 1996;81:27-34.
14. Hoa TTM, Hasunuma T, Aono H et al. Novel mechanisms of selective apoptosis in synovial T cells of patients with rheumatoid arthritis. J Rheumatol 1996;23:1332-7.
15. Cantwell MJ, Hua T, Zvaifler NJ, Kipps TJ. Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum 1997;40:1644-52.
16. Matsumoto S, Muller-Ladner U, Gay RE, Nishioka K, Gay S. Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts. J Rheumatol 1996;23:1345-52.
17. Wakisaka S, Suzuki N, Takeba Y et al. Modulation by proinflammatory cytokines of Fas/Fas-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis (RA). Clin Exp Immunol 1998;114:119-28.
18. Okamato K, Fujisawa K, Hasunuma T, Kobata T, Sumida T, Nishioka K. Selective activation of the JNK/AP-1 pathway in Fas-mediated apoptosis of rheumatoid arthritis synoviocytes. Arthritis Rheum 1997;40:919-26.
19. Sun Y, Cheung HS. p53, proto-oncogene and rheumatoid arthritis. Semin Arthritis Rheum 2002;31:299-310.
20. Fuchs SY, Adler V, Buschmann T, Wu X, Ronai Z: Mdm2 association with p53 targets its ubiquitination. Oncogene 1998;17:2543-7.
21. Catrina AI, Ulfgren AK, Linblad S, Grondal L, Klareskog L. Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium. Ann Rheum Dis 2002;61:934-6.
22. Pope RM. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat Rev Immunol 2001;2:527-35.