The upregulation of endothelial nitric oxide synthase and urotensin-II is associated with pulmonary hypertension and vascular diseases in rats produced by aortocaval shunting

Heart and Vessels

Volumn 19, Issue 2, 2004, Pages 81-88

  Qi, Jianguang ^a   Du, Junbao ^a   Tang, Xiuying ^a   Li, Jian ^a   Wei, Bing ^a   Tang, Chaoshu ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Carbon monoxide; Left to right shunt; Nitric oxide; Pulmonary hypertension; Urotensin II

Indexed keywords

CARBON MONOXIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME OXYGENASE 1; NITRIC OXIDE; UROTENSIN II;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTOCAVAL FISTULA; ARTICLE; BLOOD VESSEL WALL; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; SPECTROPHOTOMETRY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; UPREGULATION;

ANIMALS; ARTERIOVENOUS SHUNT, SURGICAL; CARBON MONOXIDE; ENDOTHELIUM, VASCULAR; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HYPERTENSION, PULMONARY; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PULMONARY ARTERY; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION; UROTENSINS; VASCULAR DISEASES;

EID: 1842863447     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00380-003-0739-3     Document Type: Article

References (25)

1. Basnet NB, Awa S, Hishi T, Yanagisawa M (2000) Pulmonary arterial compliance in children with atrial and ventricular septal defect. Heart Vessels 15:61-69
2. Ignarro LJ (1989) Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res 65:1-2
3. Garg UC, Hassid A (1989) Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83:1774-1777
4. Winberg P, Lundell BP, Gustafsson LE (1994) Effect of inhaled nitric oxide on raised pulmonary vascular resistance in children with congenital heart disease. Br Heart J 71:282-286
5. Matsui J, Yahagi N, Kumon K, Hayash H, Watanabe Y, Haruna M, Tanigami H, Yagihara T, Takamoto S, Kamiya T (1997) Effects of inhaled nitric oxide on postoperative pulmonary circulation in patients with congenital heart disease. Artif Organs 21:17-20
6. Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer JS (1998) Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol 275:H1643-H1651
7. Komai H, Naito Y, Aimi Y, Kimura H (2001) Nitric oxide synthase expression in lungs of pulmonary hypertensive patients with heart disease. Cardiovasc Res 10:29-32
8. Mason NA, Springull DR, Burke M, Pollock J, Mikhail G, Yacoub MH, Polak JM (1998) High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension. J Pathol 185:313-318
9. Everett AD, Le Cras TD, Xue C, Johns RA (1998) eNOS expression is not altered in pulmonary vascular remodeling due to increased pulmonary blood flow. Am J Physiol 274:L1058-L1065
10. Marines MD (1997) The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37:517-554
11. Morita T, Kourembanas S (1995) Endothelial cell expression of vasoconstrictors and growth factor is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest 96:2676-2682
12. Zhang Y, Li J, Cao J, Chen J, Yang J, Zhang Z, Du J, Tang C (2002) Effect of chronic hypoxia on contents of urotensin II and its functional receptors in rat myocardium. Heart Vessels 16:64-68
13. Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Dias J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Douglas SA (1999) Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 401:282-286
14. MacLean MR, Alexander D, Stirrat A, Gallagher M, Douglas SA, Ohlstein EH, Morecroft I, Polland K (2000) Contractile responses to human urotensin-II in rat and human pulmonary arteries: effect of endothelial factors and chronic hypoxia in the rat. Br J Pharmacol 130:201-204
15. Watanabe T, Pakala R, Katagiri T, Benedict CR (2001) Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells. Circulation 104:16-18
16. Qi JG, Du JB, Li J, Tang XY, Wei B, Tang CS (2002) Establishment of rat model of pulmonary hypertension induced by left-to-right shunt. Chin J Exp Surg 19:199-200
17. Qi JG, Du JB, Tang XY, Li J, Wei B, Tang CS (2002) The regulating effect of L-arginine on pulmonary vascular structural remodeling induced by high pulmonary blood flow. Chin Pharmacol Bull 18:543-546
18. Fullerton DA, Mitchell MB, Jones DN, Maki A, McIntyre RC (1996) Pulmonary vasomotor dysfunction is produced with chronically high pulmonary blood flow. J Thorac Cardiovasc Surg 111:190-197
19. Barth PJ, Kimpel C, Roy S, Wagner U (1993) An improved mathematical approach for the assessment of the medial thickness of pulmonary arteries. Pathol Res Pract 189:567-576
20. Chalmers AH (1991) Simple, sensitive measurement of carbon monoxide in plasma. Clin Chem 37:1442-1445
21. Heath D, Edwards JE (1958) The pathology of hypertensive pulmonary vascular disease. Circulation 18:533-547
22. Resnick N, Gimbrone MA Jr (1995) Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J 9:874-882
23. Korenaga R, Ando J, Tsuboi H, Yang W, Sakuma I, Toyo-oka T, Kamiya A (1994) Laminar flow stimulates ATP- and shear stress-dependent nitric oxide production in cultured bovine endothelial cells. Biochem Biophys Res Commun 198:213-219
24. Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, Harrison D (1995) Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol 269:C1371-C1378
25. Wagner CT, Durante W, Christodoulides N, Hellums D, Schafer A (1997) Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells. J Clin Invest 100:589-596